SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EMT'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNI_A_MTKA501_2 (CYTOCHROME P450 2C8)	2ypd	PROBABLE JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROT EIN 2C (Homo sapiens)	5 / 8	ILE A2424 ILE A2402 ILE A2409 ARG A2446 VAL A2445	None None None EMT A3498 ( 3.2A) None	1.48A	2nniA-2ypdA: undetectable	2nniA-2ypdA: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N23_A_OBNA1_1 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	2ypd	PROBABLE JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROT EIN 2C (Homo sapiens)	5 / 11	GLN A2476 ASN A2470 VAL A2323 PHE A2367 ARG A2379	EMT A3503 (-4.8A) None None None None	1.33A	3n23A-2ypdA: undetectable	3n23A-2ypdA: 16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N23_C_OBNC1_1 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	2ypd	PROBABLE JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROT EIN 2C (Homo sapiens)	5 / 11	GLN A2476 ASN A2470 VAL A2323 PHE A2367 ARG A2379	EMT A3503 (-4.8A) None None None None	1.33A	3n23C-2ypdA: undetectable	3n23C-2ypdA: 16.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2NNI_A_MTKA501_2","CYTOCHROME P450 2C8","2ypd","PROBABLE JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROT EIN 2C","Homo sapiens",5,"ILE A2424;ILE A2402;ILE A2409;ARG A2446;VAL A2445","None;None;None;EMT A3498 ( 3.2A);None","1.48A","2nniA-2ypdA:undetectable",null],["3N23_A_OBNA1_1","SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1","2ypd","PROBABLE JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROT EIN 2C","Homo sapiens",5,"GLN A2476;ASN A2470;VAL A2323;PHE A2367;ARG A2379","EMT A3503 (-4.8A);None;None;None;None","1.33A","3n23A-2ypdA:undetectable","2nniA-2ypdA:21.65"],["3N23_C_OBNC1_1","SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1","2ypd","PROBABLE JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROT EIN 2C","Homo sapiens",5,"GLN A2476;ASN A2470;VAL A2323;PHE A2367;ARG A2379","EMT A3503 (-4.8A);None;None;None;None","1.33A","3n23C-2ypdA:undetectable","3n23A-2ypdA:16.75"]]