SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EMC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		5 / 12 LEU A  93
LEU A 184
VAL A  95
CYH A  40
VAL A   4
 None
None
None
EMC  A 402 (-2.6A)
None
 1.35A 1db1A-5lf8A:
undetectable		 1db1A-5lf8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		5 / 11 PHE A 284
LEU A 184
LEU A 163
LEU A  49
ALA A  59
 None
None
None
None
EMC  A 402 ( 4.1A)
 1.01A 1h9zA-5lf8A:
undetectable		 1h9zA-5lf8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		5 / 11 PHE A 284
LEU A 184
LEU A 163
LEU A  49
ALA A  59
 None
None
None
None
EMC  A 402 ( 4.1A)
 1.00A 1ha2A-5lf8A:
undetectable		 1ha2A-5lf8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17
(Homo
sapiens) 		5 / 12 LEU A  93
LEU A 184
VAL A  95
CYH A  40
VAL A   4
 None
None
None
EMC  A 402 (-2.6A)
None
 1.31A 1ie9A-5lf8A:
undetectable		 1ie9A-5lf8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 8 ALA A  94
LEU A  95
TYR A 125
ILE A  65
 None
None
None
EMC  A 630 ( 4.1A)
 0.88A 3cldB-1cjxA:
0.0		 3cldB-1cjxA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 3lhr ZINC FINGER PROTEIN
24
(Homo
sapiens) 		4 / 5 LYS A  45
GLN A  47
LEU A  49
GLU A  50
 None
None
EMC  A  97 (-3.5A)
EMC  A  97 (-4.0A)
 0.90A 3h5gA-3lhrA:
undetectable
3h5gB-3lhrA:
undetectable		 3h5gA-3lhrA:
17.78
3h5gB-3lhrA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 3lhr ZINC FINGER PROTEIN
24
(Homo
sapiens) 		4 / 6 LYS A  45
GLN A  47
LEU A  49
GLU A  50
 None
None
EMC  A  97 (-3.5A)
EMC  A  97 (-4.0A)
 1.09A 3h5gB-3lhrA:
undetectable
3h5gC-3lhrA:
undetectable		 3h5gB-3lhrA:
17.78
3h5gC-3lhrA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 9 PHE A 122
ALA A 149
ALA A 151
SER A 142
LEU A 145
 EMC  A5501 (-4.3A)
None
None
None
None
 1.28A 4or0A-1rhyA:
undetectable		 4or0A-1rhyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN
(Caenorhabditis
elegans) 		3 / 3 LYS A 127
ASN A 110
SER A 147
 EMC  A 451 (-3.0A)
EMC  A 453 (-3.2A)
EMC  A 453 (-3.4A)
 1.26A 5yw0A-1emsA:
0.0		 5yw0A-1emsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A  79
CYH A  78
SER A  76
LEU A  26
ILE A  57
 EMC  A 630 ( 4.2A)
EMC  A 630 (-2.4A)
None
None
None
 1.37A 6md4A-1cjxA:
0.0		 6md4A-1cjxA:
15.43