SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EIC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		7 / 12 PHE A  16
VAL A  23
SER A  53
THR A  60
ALA A  75
ARG A 126
TYR A 128
 None
None
EIC  A 601 (-3.1A)
None
EIC  A 601 ( 4.1A)
EIC  A 601 (-4.5A)
EIC  A 601 (-4.7A)
 1.39A 2qm9A-2q9sA:
26.6		 2qm9A-2q9sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		12 / 12 PHE A  16
VAL A  25
ALA A  33
SER A  53
SER A  55
THR A  60
ALA A  75
ASP A  76
ARG A  78
CYH A 117
ARG A 126
TYR A 128
 None
None
EIC  A 601 (-3.5A)
EIC  A 601 (-3.1A)
None
None
EIC  A 601 ( 4.1A)
EIC  A 601 (-3.6A)
EIC  A 601 ( 4.9A)
EIC  A 601 (-3.3A)
EIC  A 601 (-4.5A)
EIC  A 601 (-4.7A)
 0.37A 2qm9A-2q9sA:
26.6		 2qm9A-2q9sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		4 / 4 TYR A  19
MET A  20
PRO A  38
ILE A 104
 None
EIC  A 601 ( 4.1A)
EIC  A 601 (-4.6A)
EIC  A 601 ( 4.5A)
 0.24A 2qm9A-2q9sA:
26.6		 2qm9A-2q9sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		12 / 12 PHE A  16
TYR A  19
VAL A  25
SER A  53
SER A  55
THR A  60
ALA A  75
ARG A  78
ILE A 104
CYH A 117
ARG A 126
TYR A 128
 None
None
None
EIC  A 601 (-3.1A)
None
None
EIC  A 601 ( 4.1A)
EIC  A 601 ( 4.9A)
EIC  A 601 ( 4.5A)
EIC  A 601 (-3.3A)
EIC  A 601 (-4.5A)
EIC  A 601 (-4.7A)
 0.34A 2qm9B-2q9sA:
27.3		 2qm9B-2q9sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		7 / 12 PHE A  16
VAL A  23
SER A  53
THR A  60
ALA A  75
ARG A 126
TYR A 128
 None
None
EIC  A 601 (-3.1A)
None
EIC  A 601 ( 4.1A)
EIC  A 601 (-4.5A)
EIC  A 601 (-4.7A)
 1.33A 2qm9B-2q9sA:
27.3		 2qm9B-2q9sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		4 / 4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 EIC  A 601 ( 4.1A)
EIC  A 601 (-4.6A)
EIC  A 601 (-3.6A)
None
 0.13A 2qm9B-2q9sA:
27.3		 2qm9B-2q9sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		4 / 6 ARG A 126
VAL A 115
ILE A 104
TYR A 128
 EIC  A 601 (-4.5A)
EIC  A 601 (-4.3A)
EIC  A 601 ( 4.5A)
EIC  A 601 (-4.7A)
 1.13A 2yfbB-2q9sA:
undetectable		 2yfbB-2q9sA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		4 / 8 GLU A  72
SER A  82
GLN A  93
CYH A 117
 None
None
None
EIC  A 601 (-3.3A)
 1.18A 3b9lA-2q9sA:
undetectable		 3b9lA-2q9sA:
14.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		12 / 12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ILE A 104
ARG A 106
VAL A 115
CYH A 117
ARG A 126
TYR A 128
 None
EIC  A 601 ( 4.1A)
None
EIC  A 601 (-4.6A)
EIC  A 601 (-3.6A)
EIC  A 601 ( 4.9A)
EIC  A 601 ( 4.5A)
None
EIC  A 601 (-4.3A)
EIC  A 601 (-3.3A)
EIC  A 601 (-4.5A)
EIC  A 601 (-4.7A)
 0.55A 3p6gA-2q9sA:
25.7		 3p6gA-2q9sA:
81.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		5 / 12 PHE A  16
VAL A  23
PRO A  38
ARG A 126
TYR A 128
 None
None
EIC  A 601 (-4.6A)
EIC  A 601 (-4.5A)
EIC  A 601 (-4.7A)
 1.29A 3p6gA-2q9sA:
25.7		 3p6gA-2q9sA:
81.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		7 / 7 PHE A  16
MET A  20
ASP A  76
ILE A 104
VAL A 115
ARG A 126
TYR A 128
 None
EIC  A 601 ( 4.1A)
EIC  A 601 (-3.6A)
EIC  A 601 ( 4.5A)
EIC  A 601 (-4.3A)
EIC  A 601 (-4.5A)
EIC  A 601 (-4.7A)
 0.54A 3p6hA-2q9sA:
25.7		 3p6hA-2q9sA:
81.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		5 / 12 PHE A  16
TYR A  19
ALA A  33
ILE A  51
SER A  55
 None
None
EIC  A 601 (-3.5A)
None
None
 0.74A 5h8tA-2q9sA:
20.1		 5h8tA-2q9sA:
31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		6 / 12 PHE A  16
TYR A  19
VAL A  25
ALA A  33
ILE A  51
SER A  55
 None
None
None
EIC  A 601 (-3.5A)
None
None
 0.83A 5hbsA-2q9sA:
20.0		 5hbsA-2q9sA:
31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2q9s FATTY ACID-BINDING
PROTEIN
(Mus
musculus) 		6 / 12 PHE A  16
VAL A  25
ALA A  33
PRO A  38
ILE A  51
SER A  55
 None
None
EIC  A 601 (-3.5A)
EIC  A 601 (-4.6A)
None
None
 0.88A 5hbsA-2q9sA:
20.0		 5hbsA-2q9sA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4nyq MILK PROTEIN
(Diploptera
punctata) 		4 / 7 ILE A  29
GLN A  32
ILE A  36
THR A  52
 None
EIC  A 208 (-3.8A)
OLA  A 207 ( 4.6A)
NAG  A 201 (-3.7A)
 0.98A 6cduF-4nyqA:
undetectable
6cduG-4nyqA:
undetectable		 6cduF-4nyqA:
16.72
6cduG-4nyqA:
16.72