SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EGY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 117
PRO A 477
ILE A  37
LEU A  33
 EGY  A 801 (-4.8A)
None
None
None
 1.10A 1ya4B-6c26A:
undetectable		 1ya4B-6c26A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 116
ASN A 113
VAL A  36
ILE A  42
 None
EGY  A 801 (-3.3A)
None
None
 1.08A 1z2bC-6c26A:
undetectable		 1z2bC-6c26A:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA512_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		5 / 10 MET A 267
ALA A 269
TYR A 243
HIS A 266
GLY A 271
 EGY  A 803 (-4.6A)
None
None
None
EGY  A 803 ( 4.4A)
 1.47A 2zm8A-6c26A:
undetectable		 2zm8A-6c26A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		5 / 8 MET A 267
ALA A 269
TYR A 243
HIS A 266
GLY A 271
 EGY  A 803 (-4.6A)
None
None
None
EGY  A 803 ( 4.4A)
 1.39A 2zm9A-6c26A:
undetectable		 2zm9A-6c26A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 196
PHE A 200
PHE A 181
 EGY  1 502 ( 3.7A)
None
None
 0.81A 3cr5X-6c26A:
undetectable		 3cr5X-6c26A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 216
ASP A 265
PHE A 398
LEU A 394
 None
None
None
EGY  3 401 ( 4.8A)
 1.05A 4f8hA-6c26A:
2.2
4f8hB-6c26A:
2.2		 4f8hA-6c26A:
13.65
4f8hB-6c26A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 216
ASP A 265
PHE A 398
LEU A 394
 None
None
None
EGY  3 401 ( 4.8A)
 1.05A 4f8hB-6c26A:
2.2
4f8hC-6c26A:
2.3		 4f8hB-6c26A:
13.65
4f8hC-6c26A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 216
ASP A 265
PHE A 398
LEU A 394
 None
None
None
EGY  3 401 ( 4.8A)
 1.04A 4f8hC-6c26A:
2.3
4f8hD-6c26A:
2.2		 4f8hC-6c26A:
13.65
4f8hD-6c26A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 216
ASP A 265
PHE A 398
LEU A 394
 None
None
None
EGY  3 401 ( 4.8A)
 1.06A 4f8hD-6c26A:
2.2
4f8hE-6c26A:
2.2		 4f8hD-6c26A:
13.65
4f8hE-6c26A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 170
LEU A 121
PHE A 118
TYR A 203
THR A 173
 None
EGY  A 801 ( 3.7A)
None
EGY  C 301 (-4.6A)
None
 1.41A 4i1nA-6c26A:
undetectable		 4i1nA-6c26A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 253
TYR A 203
SER A 206
ALA A 169
ALA A 171
 EGY  C 301 ( 4.7A)
EGY  C 301 (-4.6A)
EGY  C 301 ( 3.9A)
None
None
 1.37A 4u14A-6c26A:
undetectable		 4u14A-6c26A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1
DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 PHE A  39
ASN A 113
TYR A  52
LEU 1 310
GLY 1 309
 None
EGY  A 801 (-3.3A)
None
None
None
 1.19A 6r2eE-6c26A:
undetectable		 6r2eE-6c26A:
undetectable