SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EGR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 416
ASP A 456
GLY A 453
SER A 452
HIS A 451
 None
None
None
None
EGR  A 501 (-3.8A)
 1.13A 1nbiA-4j0kA:
2.0		 1nbiA-4j0kA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 416
ASP A 456
GLY A 453
SER A 452
HIS A 451
 None
None
None
None
EGR  A 501 (-3.8A)
 1.14A 1nbiB-4j0kA:
2.0		 1nbiB-4j0kA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 416
ASP A 421
ILE A 206
ILE A 413
ALA A 425
 None
EGR  A 501 (-3.5A)
EGR  A 501 (-4.0A)
None
None
 1.02A 1sguB-4j0kA:
undetectable		 1sguB-4j0kA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 10 GLY A 416
ASP A 421
ILE A 206
ILE A 413
ALA A 425
 None
EGR  A 501 (-3.5A)
EGR  A 501 (-4.0A)
None
None
 1.00A 1sh9B-4j0kA:
undetectable		 1sh9B-4j0kA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 9 GLY A  76
GLY A  77
SER A 163
ALA A 164
HIS A 451
 EGR  A 501 (-3.3A)
EGR  A 501 (-3.3A)
EGR  A 501 (-2.6A)
EGR  A 501 (-3.7A)
EGR  A 501 (-3.8A)
 0.55A 2aceA-4j0kA:
19.1		 2aceA-4j0kA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 416
ASP A 421
ILE A 206
ILE A 413
ALA A 425
 None
EGR  A 501 (-3.5A)
EGR  A 501 (-4.0A)
None
None
 1.07A 2b7zA-4j0kA:
undetectable		 2b7zA-4j0kA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 416
ASP A 421
ILE A 206
ILE A 413
ALA A 425
 None
EGR  A 501 (-3.5A)
EGR  A 501 (-4.0A)
None
None
 1.04A 2b7zB-4j0kA:
undetectable		 2b7zB-4j0kA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 8 GLY A  76
GLY A  77
ALA A 164
HIS A 451
 EGR  A 501 (-3.3A)
EGR  A 501 (-3.3A)
EGR  A 501 (-3.7A)
EGR  A 501 (-3.8A)
 0.51A 2ha4A-4j0kA:
19.1		 2ha4A-4j0kA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 7 GLY A  76
GLY A  77
ALA A 164
HIS A 451
 EGR  A 501 (-3.3A)
EGR  A 501 (-3.3A)
EGR  A 501 (-3.7A)
EGR  A 501 (-3.8A)
 0.49A 2ha4B-4j0kA:
19.0		 2ha4B-4j0kA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 SER A 163
GLU A 357
ASP A 421
 EGR  A 501 (-2.6A)
EGR  A 501 (-2.9A)
EGR  A 501 (-3.5A)
 0.69A 2zthA-4j0kA:
2.4		 2zthA-4j0kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 SER A 163
GLU A 357
ASP A 421
 EGR  A 501 (-2.6A)
EGR  A 501 (-2.9A)
EGR  A 501 (-3.5A)
 0.86A 3bwmA-4j0kA:
2.5		 3bwmA-4j0kA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 SER A 163
GLU A 357
ASP A 421
 EGR  A 501 (-2.6A)
EGR  A 501 (-2.9A)
EGR  A 501 (-3.5A)
 0.76A 3bwyA-4j0kA:
2.2		 3bwyA-4j0kA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 GLU A 357
ASP A 213
ASP A 421
 EGR  A 501 (-2.9A)
None
EGR  A 501 (-3.5A)
 0.72A 3jb2A-4j0kA:
undetectable		 3jb2A-4j0kA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 10 ILE A 206
TRP A 447
ALA A 444
LEU A 445
ALA A 417
 EGR  A 501 (-4.0A)
None
None
None
None
 1.39A 3lw5B-4j0kA:
undetectable		 3lw5B-4j0kA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 7 GLY A  76
GLY A  77
SER A 163
HIS A 451
 EGR  A 501 (-3.3A)
EGR  A 501 (-3.3A)
EGR  A 501 (-2.6A)
EGR  A 501 (-3.8A)
 0.68A 3o9mA-4j0kA:
2.4		 3o9mA-4j0kA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 6 GLY A  76
GLY A  77
SER A 163
HIS A 451
 EGR  A 501 (-3.3A)
EGR  A 501 (-3.3A)
EGR  A 501 (-2.6A)
EGR  A 501 (-3.8A)
 0.76A 3o9mB-4j0kA:
19.2		 3o9mB-4j0kA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 8 SER A 163
ILE A 428
VAL A 296
PHE A 424
 EGR  A 501 (-2.6A)
None
None
None
 1.01A 4dx7B-4j0kA:
undetectable		 4dx7B-4j0kA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 8 PHE A 132
TYR A  78
LEU A 209
ILE A 133
 None
EGR  A 501 (-4.5A)
None
None
 0.89A 4l4cB-4j0kA:
undetectable		 4l4cB-4j0kA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4j0k TANNASE
(Lactobacillus
plantarum) 		4 / 6 VAL A 296
LEU A 300
LEU A 336
PHE A 348
 None
None
PGE  A 502 (-4.7A)
EGR  A 501 ( 4.7A)
 1.09A 4o1zA-4j0kA:
undetectable		 4o1zA-4j0kA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4j0k TANNASE
(Lactobacillus
plantarum) 		3 / 3 SER A 163
GLU A 357
ASP A 421
 EGR  A 501 (-2.6A)
EGR  A 501 (-2.9A)
EGR  A 501 (-3.5A)
 0.83A 4xudA-4j0kA:
2.0		 4xudA-4j0kA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 PHE A 265
TYR A 268
LEU A 269
ILE A 206
ILE A 429
 None
None
None
EGR  A 501 (-4.0A)
None
 1.10A 5h8tA-4j0kA:
undetectable		 5h8tA-4j0kA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4j0k TANNASE
(Lactobacillus
plantarum) 		5 / 12 VAL A 200
GLY A 165
ALA A 164
LEU A 360
LEU A 209
 None
None
EGR  A 501 (-3.7A)
None
None
 1.17A 5x23A-4j0kA:
undetectable		 5x23A-4j0kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 4j0k TANNASE
(Lactobacillus
plantarum) 		6 / 12 ALA A 174
VAL A 200
GLY A 165
ALA A 164
LEU A 360
LEU A 209
 None
None
None
EGR  A 501 (-3.7A)
None
None
 1.33A 5xxiA-4j0kA:
undetectable		 5xxiA-4j0kA:
22.01