SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EEM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 12 ALA A 118
LEU A  93
TYR A 153
LEU A 164
ILE A 145
 None
EEM  A1185 (-3.9A)
None
None
None
 1.01A 1s9pA-5apgA:
undetectable		 1s9pA-5apgA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 12 ALA A 118
LEU A  93
TYR A 153
LEU A 164
ILE A 145
 None
EEM  A1185 (-3.9A)
None
None
None
 1.10A 1s9pD-5apgA:
undetectable		 1s9pD-5apgA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		5 / 11 LEU A 154
LEU A 181
VAL A 172
GLY A 230
TYR A 227
 None
None
EEM  A 401 (-3.9A)
None
None
 1.25A 1y4lB-4rh0A:
undetectable		 1y4lB-4rh0A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 12 LEU A  45
LEU A  93
LEU A 110
THR A 112
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-4.1A)
EEM  A1185 (-3.9A)
EEM  A1185 (-3.4A)
 0.46A 2egvA-5apgA:
5.6		 2egvA-5apgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 12 LEU A  45
LEU A  93
LEU A 110
THR A 112
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-4.1A)
EEM  A1185 (-3.9A)
EEM  A1185 (-3.4A)
 0.42A 2egvB-5apgA:
4.6		 2egvB-5apgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		3 / 3 ARG A 298
HIS A 272
TYR A 312
 None
EEM  A 401 ( 4.7A)
None
 1.23A 4fu8A-4rh0A:
undetectable		 4fu8A-4rh0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		3 / 3 ARG A 298
HIS A 272
TYR A 312
 None
EEM  A 401 ( 4.7A)
None
 1.31A 4fu9A-4rh0A:
undetectable		 4fu9A-4rh0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		5 / 11 TYR A  96
CYH A  97
TYR A  98
SER A 195
ILE A 270
 EEM  A 401 ( 4.6A)
SF4  A 409 (-2.1A)
EEM  A 401 (-4.1A)
EEM  A 401 (-2.4A)
EEM  A 401 ( 4.3A)
 1.21A 4k37A-4rh0A:
11.0		 4k37A-4rh0A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 4rh0 SPORE PHOTOPRODUCT
LYASE
(Geobacillus
thermodenitrific
ans) 		4 / 4 ILE A 270
ARG A 193
TYR A 339
GLU A 268
 EEM  A 401 ( 4.3A)
None
None
None
 1.38A 4zzbD-4rh0A:
undetectable		 4zzbD-4rh0A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 12 LEU A  45
PRO A  47
ARG A  92
LEU A  93
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
None
EEM  A1185 (-3.9A)
EEM  A1185 (-3.4A)
 0.78A 5h5fA-5apgA:
7.3		 5h5fA-5apgA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 11 ASN A  18
VAL A 116
THR A  19
PRO A   3
LEU A  66
 EEM  A1185 (-3.8A)
None
EEM  A1185 (-2.7A)
None
None
 1.46A 5jh7D-5apgA:
undetectable		 5jh7D-5apgA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 9 LEU A  45
PRO A  47
LEU A  93
LEU A 110
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-4.1A)
EEM  A1185 (-3.4A)
 0.71A 5o96A-5apgA:
5.4
5o96B-5apgA:
5.2		 5o96A-5apgA:
21.51
5o96B-5apgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 10 LEU A  45
PRO A  47
LEU A  93
LEU A 110
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-4.1A)
EEM  A1185 (-3.4A)
 0.72A 5o96G-5apgA:
4.8
5o96H-5apgA:
5.3		 5o96G-5apgA:
21.51
5o96H-5apgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 10 LEU A  45
PRO A  47
LEU A 110
THR A 112
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-4.1A)
EEM  A1185 (-3.9A)
EEM  A1185 (-3.4A)
 0.72A 5o96G-5apgA:
4.8
5o96H-5apgA:
5.3		 5o96G-5apgA:
21.51
5o96H-5apgA:
21.51