SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EEE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 10 GLY A  27
SER A  94
MET A  95
TRP A  28
HIS A 251
 EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
EEE  A 300 (-4.6A)
None
EEE  A 300 (-4.3A)
 1.29A 1a8uA-3heaA:
43.3		 1a8uA-3heaA:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 10 GLY A  27
SER A  94
MET A  95
TRP A  28
HIS A 251
 EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
EEE  A 300 (-4.6A)
None
EEE  A 300 (-4.3A)
 1.31A 1a8uB-3heaA:
43.3		 1a8uB-3heaA:
39.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		4 / 5 THR A 230
ASP A 222
HIS A 251
HIS A 218
 None
None
EEE  A 300 (-4.3A)
None
 1.10A 1ei6A-3heaA:
undetectable		 1ei6A-3heaA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		4 / 6 THR A 179
PHE A 162
PHE A  93
GLY A 252
 GOL  A 274 (-4.1A)
None
EEE  A 300 (-4.5A)
None
 1.11A 1icuA-3heaA:
undetectable
1icuB-3heaA:
undetectable		 1icuA-3heaA:
21.75
1icuB-3heaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		4 / 5 PHE A  93
GLY A 252
THR A 179
PHE A 162
 EEE  A 300 (-4.5A)
None
GOL  A 274 (-4.1A)
None
 1.10A 1icuC-3heaA:
undetectable
1icuD-3heaA:
undetectable		 1icuC-3heaA:
21.75
1icuD-3heaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		4 / 5 PHE A  93
GLY A 252
THR A 179
PHE A 162
 EEE  A 300 (-4.5A)
None
GOL  A 274 (-4.1A)
None
 1.21A 1icvA-3heaA:
undetectable
1icvB-3heaA:
undetectable		 1icvA-3heaA:
21.75
1icvB-3heaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		4 / 6 THR A 179
PHE A 162
PHE A  93
GLY A 252
 GOL  A 274 (-4.1A)
None
EEE  A 300 (-4.5A)
None
 1.15A 1kqbC-3heaA:
undetectable
1kqbD-3heaA:
undetectable		 1kqbC-3heaA:
23.71
1kqbD-3heaA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		4 / 6 PHE A  93
GLY A 252
THR A 179
PHE A 162
 EEE  A 300 (-4.5A)
None
GOL  A 274 (-4.1A)
None
 1.09A 1kqbC-3heaA:
undetectable
1kqbD-3heaA:
undetectable		 1kqbC-3heaA:
23.71
1kqbD-3heaA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 12 ARG A 151
SER A  94
VAL A 121
VAL A 225
HIS A 251
 None
EEE  A 300 (-1.4A)
None
None
EEE  A 300 (-4.3A)
 1.34A 1x70B-3heaA:
undetectable		 1x70B-3heaA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		4 / 7 VAL A 195
THR A 196
PHE A 198
THR A 201
 None
GOL  A 273 (-3.6A)
EEE  A 300 ( 4.3A)
None
 1.14A 2kotA-3heaA:
undetectable		 2kotA-3heaA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 2qfl INOSITOL-1-MONOPHOSP
HATASE
(Escherichia
coli) 		5 / 12 GLY A  88
GLY A 186
LEU A 190
PHE A  92
ASP A  87
 ACT  A 375 (-3.7A)
EEE  A 376 (-4.2A)
None
None
EEE  A 376 (-2.7A)
 1.09A 2yvlD-2qflA:
undetectable		 2yvlD-2qflA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 12 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 1.11A 3keeA-3heaA:
undetectable		 3keeA-3heaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 12 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 1.07A 3keeB-3heaA:
undetectable		 3keeB-3heaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 12 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 1.08A 3keeC-3heaA:
undetectable		 3keeC-3heaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 12 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 1.07A 3keeD-3heaA:
undetectable		 3keeD-3heaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 12 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 0.96A 3sueA-3heaA:
undetectable		 3sueA-3heaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 12 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 0.93A 3sueB-3heaA:
undetectable		 3sueB-3heaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 12 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 1.03A 3sueC-3heaA:
undetectable		 3sueC-3heaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 12 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 0.98A 3sufA-3heaA:
undetectable		 3sufA-3heaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		6 / 12 VAL A 225
HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 None
EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 1.16A 3sufB-3heaA:
undetectable		 3sufB-3heaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 11 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 1.07A 3sufC-3heaA:
undetectable		 3sufC-3heaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 12 ARG A 151
SER A  94
VAL A 121
VAL A 225
HIS A 251
 None
EEE  A 300 (-1.4A)
None
None
EEE  A 300 (-4.3A)
 1.29A 4ffwA-3heaA:
15.9		 4ffwA-3heaA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE
(Methanobrevibact
er
ruminantium) 		3 / 3 THR A 124
ASN A 189
PHE A 288
 None
IPA  A 402 (-3.0A)
EEE  A 401 (-4.1A)
 0.73A 4pd9A-4fioA:
undetectable		 4pd9A-4fioA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 2qfl INOSITOL-1-MONOPHOSP
HATASE
(Escherichia
coli) 		4 / 8 ASP A 212
ASP A  87
ASP A  84
ILE A  19
 EEE  A 376 ( 4.7A)
EEE  A 376 (-2.7A)
None
None
 1.02A 4xjeA-2qflA:
undetectable		 4xjeA-2qflA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 2qfl INOSITOL-1-MONOPHOSP
HATASE
(Escherichia
coli) 		4 / 8 ASP A 212
ASP A  87
ASP A  84
ILE A  19
 EEE  A 376 ( 4.7A)
EEE  A 376 (-2.7A)
None
None
 1.01A 5cfsA-2qflA:
undetectable		 5cfsA-2qflA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 12 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 0.99A 6c2mC-3heaA:
undetectable		 6c2mC-3heaA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3hea ARYLESTERASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 147
SER A  94
PHE A 125
HIS A 251
VAL A 121
 None
EEE  A 300 (-1.4A)
None
EEE  A 300 (-4.3A)
None
 1.33A 6djzB-3heaA:
undetectable		 6djzB-3heaA:
21.31