SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EE4'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 366
GLY A 367
VAL A 374
ALA A 388
VAL A 422
ASN A 489
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
None
EE4  A 701 ( 4.9A)
DMS  A 702 ( 3.1A)
 0.76A 1fmoE-6c0tA:
41.6		 1fmoE-6c0tA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 366
GLY A 367
VAL A 374
ALA A 388
VAL A 422
GLU A 445
ASN A 489
PHE A 649
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
None
EE4  A 701 (-3.3A)
EE4  A 701 ( 4.9A)
None
 0.51A 1fmoE-6c0tA:
41.6		 1fmoE-6c0tA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A 366
VAL A 374
ALA A 388
GLU A 409
MET A 413
GLY A 444
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
None
None
 0.72A 1iepB-6c0tA:
17.1		 1iepB-6c0tA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 374
ALA A 388
GLU A 409
MET A 413
VAL A 422
GLY A 444
 EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
None
None
None
 0.86A 1opjB-6c0tA:
16.4		 1opjB-6c0tA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 374
ALA A 388
GLU A 409
CYH A 441
LEU A 475
 EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
EE4  A 701 (-4.6A)
None
 0.53A 1uwjA-6c0tA:
7.6		 1uwjA-6c0tA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 366
GLY A 367
VAL A 374
ALA A 388
ASP A 484
LYS A 486
ASN A 489
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 ( 4.4A)
None
EE4  A 701 ( 4.9A)
DMS  A 702 ( 3.1A)
 0.55A 2fumA-6c0tA:
20.6		 2fumA-6c0tA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 366
GLY A 367
VAL A 374
ALA A 388
MET A 438
LYS A 486
ASN A 489
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
EE4  A 701 ( 3.8A)
None
EE4  A 701 ( 4.9A)
DMS  A 702 ( 3.1A)
 0.48A 2fumB-6c0tA:
20.0		 2fumB-6c0tA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 366
GLY A 367
VAL A 374
ALA A 388
MET A 438
ASN A 489
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
EE4  A 701 ( 3.8A)
EE4  A 701 ( 4.9A)
DMS  A 702 ( 3.1A)
 0.64A 2fumC-6c0tA:
19.4		 2fumC-6c0tA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 366
GLY A 367
GLY A 369
VAL A 374
ALA A 388
MET A 438
ASN A 489
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-3.4A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
EE4  A 701 ( 3.8A)
EE4  A 701 ( 4.9A)
DMS  A 702 ( 3.1A)
 0.71A 2fumD-6c0tA:
24.2		 2fumD-6c0tA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 366
GLY A 367
VAL A 374
ALA A 388
MET A 438
LYS A 486
ASN A 489
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
EE4  A 701 ( 3.8A)
None
EE4  A 701 ( 4.9A)
DMS  A 702 ( 3.1A)
 0.73A 2fumD-6c0tA:
24.2		 2fumD-6c0tA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 GLN A 378
PHE A 387
LEU A 366
PHE A 649
 None
PGE  A 703 (-4.4A)
EE4  A 701 ( 4.6A)
None
 0.90A 2zxwP-6c0tA:
1.7
2zxwW-6c0tA:
undetectable		 2zxwP-6c0tA:
undetectable
2zxwW-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 GLN A 378
PHE A 387
LEU A 366
PHE A 649
 None
PGE  A 703 (-4.4A)
EE4  A 701 ( 4.6A)
None
 0.94A 3ablP-6c0tA:
1.9
3ablW-6c0tA:
undetectable		 3ablP-6c0tA:
undetectable
3ablW-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 366
GLY A 367
VAL A 374
ALA A 388
LYS A 390
MET A 438
ASN A 489
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
EE4  A 701 ( 3.8A)
EE4  A 701 ( 4.9A)
DMS  A 702 ( 3.1A)
 0.53A 3eygA-6c0tA:
18.9		 3eygA-6c0tA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 366
GLY A 367
GLY A 369
VAL A 374
ALA A 388
VAL A 422
MET A 438
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-3.4A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
None
EE4  A 701 ( 3.8A)
DMS  A 702 ( 3.1A)
 0.77A 3fupB-6c0tA:
25.5		 3fupB-6c0tA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 366
GLY A 367
VAL A 374
ALA A 388
LYS A 390
VAL A 422
MET A 438
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
None
EE4  A 701 ( 3.8A)
DMS  A 702 ( 3.1A)
 0.67A 3fupB-6c0tA:
25.5		 3fupB-6c0tA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 366
GLY A 367
VAL A 374
ALA A 388
LYS A 390
VAL A 422
MET A 438
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
None
EE4  A 701 ( 3.8A)
DMS  A 702 ( 3.1A)
 0.70A 3lxkA-6c0tA:
24.8		 3lxkA-6c0tA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 366
VAL A 374
ALA A 388
GLU A 409
CYH A 441
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
EE4  A 701 (-4.6A)
 0.55A 3wzdA-6c0tA:
16.3		 3wzdA-6c0tA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 366
VAL A 374
ALA A 388
LYS A 390
GLU A 409
VAL A 422
GLY A 444
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 4.2A)
None
None
 0.74A 4ag8A-6c0tA:
21.3		 4ag8A-6c0tA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 11 LEU A 366
GLY A 367
VAL A 374
ALA A 388
LYS A 390
ASN A 489
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
EE4  A 701 ( 4.9A)
DMS  A 702 ( 3.1A)
 0.73A 4o0sA-6c0tA:
32.9		 4o0sA-6c0tA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 LEU A 366
GLY A 367
VAL A 374
ALA A 388
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
 0.27A 4o0wA-6c0tA:
23.3		 4o0wA-6c0tA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		9 / 12 LEU A 366
GLY A 367
GLY A 369
GLY A 372
VAL A 374
ALA A 388
LYS A 390
ASP A 502
PHE A 649
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-3.4A)
EE4  A 701 (-4.1A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 3.1A)
None
 0.72A 4otiA-6c0tA:
23.5		 4otiA-6c0tA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 366
GLY A 367
GLY A 372
VAL A 374
ALA A 388
LYS A 390
VAL A 422
PHE A 649
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.1A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
None
None
 0.70A 4otiA-6c0tA:
23.5		 4otiA-6c0tA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 388
GLU A 409
MET A 413
LEU A 475
ARG A 483
 EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
None
None
TPO  A 517 ( 3.0A)
 1.05A 4qrcA-6c0tA:
16.3		 4qrcA-6c0tA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 374
ALA A 388
LYS A 390
GLU A 409
MET A 413
CYH A 441
 EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 4.2A)
None
EE4  A 701 (-4.6A)
 0.82A 4r7iA-6c0tA:
15.7		 4r7iA-6c0tA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 VAL A 374
ALA A 388
LYS A 390
CYH A 441
ASP A 502
PHE A 503
 EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
EE4  A 701 (-4.6A)
DMS  A 702 ( 3.1A)
None
 0.85A 4xv2A-6c0tA:
17.6		 4xv2A-6c0tA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 374
ALA A 388
LYS A 390
CYH A 441
PHE A 503
 EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
EE4  A 701 (-4.6A)
None
 0.73A 5cswA-6c0tA:
17.4		 5cswA-6c0tA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 7 GLY A 367
GLY A 369
PHE A 371
VAL A 374
LYS A 390
LEU A 392
 EE4  A 701 (-3.9A)
EE4  A 701 (-3.4A)
EE4  A 701 (-3.0A)
EE4  A 701 (-4.4A)
DMS  A 702 (-3.5A)
EE4  A 701 ( 4.6A)
 0.51A 5izjA-6c0tA:
31.6		 5izjA-6c0tA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 7 GLY A 367
GLY A 369
VAL A 374
LYS A 390
 EE4  A 701 (-3.9A)
EE4  A 701 (-3.4A)
EE4  A 701 (-4.4A)
DMS  A 702 (-3.5A)
 0.29A 5j5xA-6c0tA:
41.6		 5j5xA-6c0tA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 LEU A 366
VAL A 374
LYS A 390
GLU A 409
GLY A 444
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 4.2A)
None
 0.57A 5mo4A-6c0tA:
16.5		 5mo4A-6c0tA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 8 ALA A 388
GLU A 409
CYH A 441
ASP A 502
 EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
EE4  A 701 (-4.6A)
DMS  A 702 ( 3.1A)
 0.63A 5owrA-6c0tA:
15.6		 5owrA-6c0tA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A 376
ALA A 388
GLU A 409
MET A 413
VAL A 422
GLY A 444
 None
EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
None
None
None
 0.71A 5te0A-6c0tA:
16.3		 5te0A-6c0tA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 5 LEU A 366
VAL A 374
MET A 438
CYH A 441
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
EE4  A 701 ( 3.8A)
EE4  A 701 (-4.6A)
 0.62A 5te0A-6c0tA:
16.3		 5te0A-6c0tA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 12 LEU A 366
VAL A 374
ALA A 388
LYS A 390
GLU A 409
CYH A 441
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 4.2A)
EE4  A 701 (-4.6A)
 0.47A 5vcyA-6c0tA:
24.3		 5vcyA-6c0tA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 ALA A 388
VAL A 422
MET A 438
CYH A 441
GLY A 443
 EE4  A 701 (-3.3A)
None
EE4  A 701 ( 3.8A)
EE4  A 701 (-4.6A)
None
 0.86A 5w5vA-6c0tA:
14.7		 5w5vA-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 LEU A 366
ALA A 388
VAL A 422
MET A 438
CYH A 441
GLY A 444
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.3A)
None
EE4  A 701 ( 3.8A)
EE4  A 701 (-4.6A)
None
 0.82A 5w5vA-6c0tA:
14.7		 5w5vA-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		6 / 9 LEU A 366
ALA A 388
VAL A 422
MET A 438
GLY A 444
THR A 448
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.3A)
None
EE4  A 701 ( 3.8A)
None
None
 1.04A 5w5vA-6c0tA:
14.7		 5w5vA-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 LEU A 376
ALA A 388
VAL A 422
MET A 438
CYH A 441
 None
EE4  A 701 (-3.3A)
None
EE4  A 701 ( 3.8A)
EE4  A 701 (-4.6A)
 1.25A 5w5vA-6c0tA:
14.7		 5w5vA-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		8 / 12 LEU A 366
VAL A 374
ALA A 388
LYS A 390
GLU A 409
CYH A 441
GLY A 444
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 4.2A)
EE4  A 701 (-4.6A)
None
DMS  A 702 ( 3.1A)
 0.85A 5y80A-6c0tA:
24.9		 5y80A-6c0tA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		7 / 12 LEU A 366
VAL A 374
ALA A 388
LYS A 390
GLU A 409
MET A 413
VAL A 422
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 4.2A)
None
None
 0.77A 6hd6B-6c0tA:
16.4		 6hd6B-6c0tA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 6 GLN A 378
PHE A 387
LEU A 366
PHE A 649
 None
PGE  A 703 (-4.4A)
EE4  A 701 ( 4.6A)
None
 1.05A 6nmpC-6c0tA:
2.1
6nmpJ-6c0tA:
undetectable		 6nmpC-6c0tA:
undetectable
6nmpJ-6c0tA:
undetectable