SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EE1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 7 SER A 411
GLY A 327
HIS A 345
THR A 396
 None
EE1  A 501 ( 3.7A)
EE1  A 501 (-3.6A)
None
 0.95A 1gtnJ-6c0eA:
undetectable
1gtnK-6c0eA:
undetectable		 1gtnJ-6c0eA:
undetectable
1gtnK-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 SER A 361
ALA A 320
GLY A 324
PHE A 399
VAL A 357
 None
None
None
None
EE1  A 501 (-4.0A)
 1.19A 1vpoH-6c0eA:
undetectable
1vpoL-6c0eA:
undetectable		 1vpoH-6c0eA:
14.98
1vpoL-6c0eA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 11 ILE A  38
GLY A  42
THR A 347
LEU A 120
GLY A 107
 None
None
EE1  A 501 (-3.6A)
None
None
 1.31A 2fn1A-6c0eA:
undetectable		 2fn1A-6c0eA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 TYR A 351
ILE A  43
HIS A 345
GLY A 325
MET A 368
 EE1  A 501 (-4.4A)
None
EE1  A 501 (-3.6A)
None
None
 1.46A 2nyrB-6c0eA:
undetectable		 2nyrB-6c0eA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		3 / 3 SER A 316
GLU A 342
ASP A 313
 None
EE1  A 501 (-3.4A)
EE1  A 501 (-3.4A)
 0.84A 3bwmA-6c0eA:
2.5		 3bwmA-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6c0e ISOCITRATE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 GLY A  40
PHE A 399
ILE A 390
GLY A 324
THR A 347
 None
None
None
None
EE1  A 501 (-3.6A)
 1.29A 5eslA-6c0eA:
undetectable		 5eslA-6c0eA:
11.60