SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EDT'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3wfa	ALPHA-GLUCOSIDASE (Bacteroides thetaiotaomicron)	4 / 7	TYR A 492 TYR A 470 TYR A 447 ILE A 502	EDT A 802 (-4.8A) None None None	1.35A	2ph9A-3wfaA: undetectable 2ph9B-3wfaA: undetectable	2ph9A-3wfaA: 15.66 2ph9B-3wfaA: 15.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RNJ_A_EDTA1_0 (BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2)	3rnj	BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2 (Homo sapiens)	4 / 4	LYS A 380 ARG A 433 LEU A 435 ASP A 436	EDT A 1 (-2.7A) EDT A 1 (-2.7A) EDT A 1 (-4.3A) EDT A 1 (-3.8A)	0.00A	3rnjA-3rnjA: 16.8	3rnjA-3rnjA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3WFA_B_EDTB802_0 (ALPHA-GLUCOSIDASE)	3wfa	ALPHA-GLUCOSIDASE (Bacteroides thetaiotaomicron)	4 / 6	ASP A 250 ASN A 488 TYR A 492 LYS A 495	EDT A 802 ( 4.5A) EDT A 802 (-2.7A) EDT A 802 (-4.8A) EDT A 802 (-2.7A)	0.48A	3wfaA-3wfaA: 72.0 3wfaB-3wfaA: 63.0	3wfaA-3wfaA: 100.00 3wfaB-3wfaA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EID_A_EDTA1111_0 (ARCHAEAL-TYPE OPSIN 2)	6eid	ARCHAEAL-TYPE OPSIN 2 (Chlamydomonas reinhardtii)	4 / 4	GLN A 49 ASN A 53 PHE A 98 TYR A 243	EDT A1111 (-4.1A) EDT A1111 (-2.6A) EDT A1111 (-4.1A) EDT A1111 (-4.7A)	0.00A	6eidA-6eidA: 42.8	6eidA-6eidA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2PH9_A_GNTA301_1","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","3wfa","ALPHA-GLUCOSIDASE","Bacteroides thetaiotaomicron",4,"TYR A 492;TYR A 470;TYR A 447;ILE A 502","EDT A 802 (-4.8A);None;None;None","1.35A","2ph9A-3wfaA:undetectable;2ph9B-3wfaA:undetectable",null],["3RNJ_A_EDTA1_0","BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2","3rnj","BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2","Homo sapiens",4,"LYS A 380;ARG A 433;LEU A 435;ASP A 436","EDT A   1 (-2.7A);EDT A   1 (-2.7A);EDT A   1 (-4.3A);EDT A   1 (-3.8A)","0.00A","3rnjA-3rnjA:16.8","2ph9A-3wfaA:15.66;2ph9B-3wfaA:15.66"],["3WFA_B_EDTB802_0","ALPHA-GLUCOSIDASE","3wfa","ALPHA-GLUCOSIDASE","Bacteroides thetaiotaomicron",4,"ASP A 250;ASN A 488;TYR A 492;LYS A 495","EDT A 802 ( 4.5A);EDT A 802 (-2.7A);EDT A 802 (-4.8A);EDT A 802 (-2.7A)","0.48A","3wfaA-3wfaA:72.0;3wfaB-3wfaA:63.0","3rnjA-3rnjA:100.00"],["6EID_A_EDTA1111_0","ARCHAEAL-TYPE OPSIN 2","6eid","ARCHAEAL-TYPE OPSIN 2","Chlamydomonas reinhardtii",4,"GLN A  49;ASN A  53;PHE A  98;TYR A 243","EDT A1111 (-4.1A);EDT A1111 (-2.6A);EDT A1111 (-4.1A);EDT A1111 (-4.7A)","0.00A","6eidA-6eidA:42.8","3wfaA-3wfaA:100.00;3wfaB-3wfaA:100.00"]]