SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EDJ'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
6 / 9 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
LEU A 146
EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 ( 4.5A)
0.67A 1muoA-6bx6A:
20.7
1muoA-6bx6A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
7 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
0.66A 2fumB-6bx6A:
22.4
2fumB-6bx6A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
6 / 12 LEU A  22
ALA A  43
MET A  93
TYR A  95
VAL A  96
ASN A 144
EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
None
0.78A 2fumC-6bx6A:
22.4
2fumC-6bx6A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
6 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
VAL A  96
EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
0.63A 2fumC-6bx6A:
22.4
2fumC-6bx6A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
6 / 12 LEU A  22
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
EDJ  A 301 (-3.9A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
0.71A 2fumC-6bx6A:
22.4
2fumC-6bx6A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
8 / 12 LEU A  22
GLY A  23
GLY A  25
GLY A  28
VAL A  30
ALA A  43
MET A  93
TYR A  95
EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
None
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.8A)
0.64A 3fupA-6bx6A:
18.4
3fupA-6bx6A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
6 / 11 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
LEU A 146
EDJ  A 301 (-3.9A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 ( 3.7A)
EDJ  A 301 ( 4.5A)
0.53A 3g0fA-6bx6A:
18.8
3g0fA-6bx6A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
7 / 12 LEU A  22
GLY A  23
GLY A  25
ALA A  43
ILE A  77
TYR A  95
VAL A  96
EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.7A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
0.63A 3lxnA-6bx6A:
18.9
3lxnA-6bx6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
7 / 12 LEU A  22
GLY A  23
GLY A  25
VAL A  30
ALA A  43
ILE A  77
TYR A  95
EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.7A)
EDJ  A 301 ( 4.8A)
0.61A 3lxnA-6bx6A:
18.9
3lxnA-6bx6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
5 / 9 ILE A  76
ILE A  77
MET A  91
TYR A  95
ILE A 155
None
EDJ  A 301 ( 4.7A)
None
EDJ  A 301 ( 4.8A)
None
0.52A 3zosA-6bx6A:
18.8
3zosA-6bx6A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
5 / 9 LEU A  22
ILE A  76
MET A  91
TYR A  95
ILE A 155
EDJ  A 301 (-3.9A)
None
None
EDJ  A 301 ( 4.8A)
None
0.45A 3zosB-6bx6A:
18.8
3zosB-6bx6A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
7 / 12 VAL A  30
ALA A  43
ILE A  77
MET A  91
TYR A  95
LEU A 146
ALA A 156
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.7A)
None
EDJ  A 301 ( 4.8A)
EDJ  A 301 ( 4.5A)
EDJ  A 301 (-3.2A)
1.12A 4bkjA-6bx6A:
18.7
4bkjA-6bx6A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
6 / 12 VAL A  30
ALA A  43
ILE A  77
MET A  91
LEU A 146
ALA A 156
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.7A)
None
EDJ  A 301 ( 4.5A)
EDJ  A 301 (-3.2A)
1.07A 4bkjB-6bx6A:
18.6
4bkjB-6bx6A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
4 / 5 VAL A  30
ILE A  76
TYR A  95
ILE A 155
None
None
EDJ  A 301 ( 4.8A)
None
0.71A 4c8bA-6bx6A:
19.9
4c8bA-6bx6A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
6 / 12 GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
LEU A 146
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 ( 4.5A)
0.74A 4qmzA-6bx6A:
14.1
4qmzA-6bx6A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
4 / 6 LEU A  22
VAL A  30
ILE A  76
ILE A 155
EDJ  A 301 (-3.9A)
None
None
None
0.72A 4tyjA-6bx6A:
19.2
4tyjA-6bx6A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
6 / 10 LEU A  22
VAL A  30
ILE A  77
TYR A  95
LEU A 146
ILE A 155
EDJ  A 301 (-3.9A)
None
EDJ  A 301 ( 4.7A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 ( 4.5A)
None
0.73A 4v04B-6bx6A:
19.4
4v04B-6bx6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
4 / 6 LEU A  22
ALA A  43
MET A  93
LEU A 146
EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.5A)
0.71A 4wboC-6bx6A:
21.2
4wboC-6bx6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
5 / 9 GLY A  23
VAL A  30
ALA A  43
ILE A  77
MET A  93
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.7A)
EDJ  A 301 ( 4.2A)
0.72A 5lw1B-6bx6A:
14.3
5lw1B-6bx6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
5 / 10 GLY A  23
VAL A  30
ALA A  43
ILE A  77
MET A  93
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.7A)
EDJ  A 301 ( 4.2A)
0.77A 5lw1E-6bx6A:
16.4
5lw1E-6bx6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
6 / 10 LEU A  22
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
EDJ  A 301 (-3.9A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
0.46A 5n3hA-6bx6A:
23.8
5n3hA-6bx6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
6 / 10 LEU A  22
VAL A  30
ALA A  43
TYR A  95
VAL A  96
LEU A 146
EDJ  A 301 (-3.9A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 (-3.7A)
EDJ  A 301 ( 4.5A)
0.68A 5n3hA-6bx6A:
23.8
5n3hA-6bx6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo
sapiens)
5 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
ALA A 156
EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 (-3.2A)
0.55A 5xv7A-6bx6A:
18.6
5xv7A-6bx6A:
26.67