SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ECN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		11 / 12 ILE B  25
PHE B  28
TYR B  29
ALA B  56
LEU B  57
VAL B  61
HIS B  85
TRP B 122
ALA B 125
TYR B 126
LEU B 129
 ECN  B 411 (-4.5A)
ECN  B 411 (-4.0A)
None
ECN  B 411 (-3.5A)
ECN  B 411 (-4.1A)
DGG  B 406 ( 4.8A)
HEM  B 404 (-3.3A)
None
DGG  B 406 ( 3.8A)
HEM  B 404 ( 3.9A)
HEM  B 404 ( 4.3A)
 0.31A 3ozuA-3ozvB:
46.1		 3ozuA-3ozvB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		11 / 12 PHE B  28
TYR B  29
ALA B  56
LEU B  57
VAL B  61
HIS B  85
LEU B 102
TRP B 122
ALA B 125
TYR B 126
LEU B 129
 ECN  B 411 (-4.0A)
None
ECN  B 411 (-3.5A)
ECN  B 411 (-4.1A)
DGG  B 406 ( 4.8A)
HEM  B 404 (-3.3A)
ECN  B 411 (-3.2A)
None
DGG  B 406 ( 3.8A)
HEM  B 404 ( 3.9A)
HEM  B 404 ( 4.3A)
 0.24A 3ozuA-3ozvB:
46.1		 3ozuA-3ozvB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4g1b FLAVOHEMOGLOBIN
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  56
LEU A  57
VAL A  61
TRP A 122
ALA A 125
 ECN  A 403 (-3.8A)
ECN  A 403 (-2.7A)
ECN  A 403 ( 4.7A)
None
None
 0.65A 3ozuA-4g1bA:
34.9		 3ozuA-4g1bA:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4g1b FLAVOHEMOGLOBIN
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  28
TYR A  29
LEU A 102
ALA A 125
TYR A 126
 ECN  A 403 (-3.6A)
ECN  A 403 (-4.8A)
ECN  A 403 (-3.8A)
None
ECN  A 403 (-4.7A)
 0.52A 3ozuA-4g1bA:
34.9		 3ozuA-4g1bA:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4g1b FLAVOHEMOGLOBIN
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  28
TYR A  29
TRP A 122
ALA A 125
TYR A 126
 ECN  A 403 (-3.6A)
ECN  A 403 (-4.8A)
None
None
ECN  A 403 (-4.7A)
 0.39A 3ozuA-4g1bA:
34.9		 3ozuA-4g1bA:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4g1b FLAVOHEMOGLOBIN
(Saccharomyces
cerevisiae) 		5 / 9 ILE A  24
PHE A  28
TYR A  29
LEU A 102
ALA A 105
 ECN  A 403 (-4.5A)
ECN  A 403 (-3.6A)
ECN  A 403 (-4.8A)
ECN  A 403 (-3.8A)
ECN  A 403 ( 4.5A)
 0.40A 3ozvB-4g1bA:
46.5		 3ozvB-4g1bA:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		4 / 8 ALA B  56
LEU B  57
LEU B 102
PRO B 398
 ECN  B 411 (-3.5A)
ECN  B 411 (-4.1A)
ECN  B 411 (-3.2A)
HEM  B 404 (-4.4A)
 0.73A 3ozwA-3ozvB:
62.3		 3ozwA-3ozvB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		6 / 8 ILE B  25
TYR B  29
GLN B  50
GLN B  53
LEU B  57
LEU B 102
 ECN  B 411 (-4.5A)
None
FAD  B 405 (-3.1A)
HEM  B 404 (-3.9A)
ECN  B 411 (-4.1A)
ECN  B 411 (-3.2A)
 0.65A 3ozwA-3ozvB:
62.3		 3ozwA-3ozvB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		6 / 8 ILE B  25
TYR B  29
GLN B  53
ALA B  56
LEU B  57
LEU B 102
 ECN  B 411 (-4.5A)
None
HEM  B 404 (-3.9A)
ECN  B 411 (-3.5A)
ECN  B 411 (-4.1A)
ECN  B 411 (-3.2A)
 0.49A 3ozwA-3ozvB:
62.3		 3ozwA-3ozvB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		10 / 12 ILE B  25
TYR B  29
HIS B  47
GLN B  52
GLN B  53
ALA B  56
LEU B  57
HIS B  85
LEU B 102
ILE B 371
 ECN  B 411 (-4.5A)
None
None
None
HEM  B 404 (-3.9A)
ECN  B 411 (-3.5A)
ECN  B 411 (-4.1A)
HEM  B 404 (-3.3A)
ECN  B 411 (-3.2A)
None
 0.74A 3ozwB-3ozvB:
63.6		 3ozwB-3ozvB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		11 / 12 ILE B  25
TYR B  29
HIS B  47
GLN B  53
ALA B  56
LEU B  57
HIS B  85
LEU B 102
ILE B 371
GLY B 397
PRO B 398
 ECN  B 411 (-4.5A)
None
None
HEM  B 404 (-3.9A)
ECN  B 411 (-3.5A)
ECN  B 411 (-4.1A)
HEM  B 404 (-3.3A)
ECN  B 411 (-3.2A)
None
FAD  B 405 ( 4.4A)
HEM  B 404 (-4.4A)
 0.64A 3ozwB-3ozvB:
63.6		 3ozwB-3ozvB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		5 / 12 PHE B  28
PHE B  43
GLN B  53
VAL B  98
TYR B 126
 ECN  B 411 (-4.0A)
HEM  B 404 ( 3.8A)
HEM  B 404 (-3.9A)
HEM  B 404 ( 4.5A)
HEM  B 404 ( 3.9A)
 0.91A 4g1bA-3ozvB:
46.5		 4g1bA-3ozvB:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		6 / 12 PHE B  28
TYR B  29
PHE B  43
VAL B  98
LEU B 102
TYR B 126
 ECN  B 411 (-4.0A)
None
HEM  B 404 ( 3.8A)
HEM  B 404 ( 4.5A)
ECN  B 411 (-3.2A)
HEM  B 404 ( 3.9A)
 0.55A 4g1bA-3ozvB:
46.5		 4g1bA-3ozvB:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		6 / 11 ILE B  24
PHE B  28
TYR B  29
LEU B  57
LEU B 102
TYR B 126
 ECN  B 411 (-3.5A)
ECN  B 411 (-4.0A)
None
ECN  B 411 (-4.1A)
ECN  B 411 (-3.2A)
HEM  B 404 ( 3.9A)
 0.83A 4g1bB-3ozvB:
46.3		 4g1bB-3ozvB:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		5 / 11 ILE B  24
PHE B  28
TYR B  29
LEU B  57
VAL B  61
 ECN  B 411 (-3.5A)
ECN  B 411 (-4.0A)
None
ECN  B 411 (-4.1A)
DGG  B 406 ( 4.8A)
 0.93A 4g1bB-3ozvB:
46.3		 4g1bB-3ozvB:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		5 / 9 ILE B  24
PHE B  28
TYR B  29
GLN B  53
VAL B  61
 ECN  B 411 (-3.5A)
ECN  B 411 (-4.0A)
None
HEM  B 404 (-3.9A)
DGG  B 406 ( 4.8A)
 1.00A 4g1bC-3ozvB:
45.3		 4g1bC-3ozvB:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		6 / 9 ILE B  24
PHE B  28
TYR B  29
GLN B  53
VAL B  98
LEU B 102
 ECN  B 411 (-3.5A)
ECN  B 411 (-4.0A)
None
HEM  B 404 (-3.9A)
HEM  B 404 ( 4.5A)
ECN  B 411 (-3.2A)
 0.77A 4g1bC-3ozvB:
45.3		 4g1bC-3ozvB:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		5 / 9 ILE B  24
TYR B  29
GLN B  53
LEU B  57
VAL B  61
 ECN  B 411 (-3.5A)
None
HEM  B 404 (-3.9A)
ECN  B 411 (-4.1A)
DGG  B 406 ( 4.8A)
 1.21A 4g1bC-3ozvB:
45.3		 4g1bC-3ozvB:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		7 / 12 ILE B  24
PHE B  28
TYR B  29
PHE B  43
LEU B  57
LEU B 102
TYR B 126
 ECN  B 411 (-3.5A)
ECN  B 411 (-4.0A)
None
HEM  B 404 ( 3.8A)
ECN  B 411 (-4.1A)
ECN  B 411 (-3.2A)
HEM  B 404 ( 3.9A)
 0.90A 4g1bD-3ozvB:
46.8		 4g1bD-3ozvB:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		6 / 12 ILE B  24
PHE B  28
TYR B  29
PHE B  43
LEU B  57
VAL B  61
 ECN  B 411 (-3.5A)
ECN  B 411 (-4.0A)
None
HEM  B 404 ( 3.8A)
ECN  B 411 (-4.1A)
DGG  B 406 ( 4.8A)
 0.90A 4g1bD-3ozvB:
46.8		 4g1bD-3ozvB:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		5 / 12 PHE B  28
PHE B  43
GLN B  53
LEU B 102
TYR B 126
 ECN  B 411 (-4.0A)
HEM  B 404 ( 3.8A)
HEM  B 404 (-3.9A)
ECN  B 411 (-3.2A)
HEM  B 404 ( 3.9A)
 1.14A 4g1bD-3ozvB:
46.8		 4g1bD-3ozvB:
37.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 3ozv FLAVOHEMOGLOBIN
(Cupriavidus
necator) 		4 / 8 GLN B  52
GLY B  51
ILE B  25
GLN B  30
 None
None
ECN  B 411 (-4.5A)
None
 1.00A 5vlmD-3ozvB:
2.1		 5vlmD-3ozvB:
20.99