SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EB4'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 6 PHE A 193
ASN A 194
ARG A 180
GLN A 215
 None
None
EB4  A1300 (-2.8A)
EB4  A1300 (-3.5A)
 1.27A 1t9uA-2xuzA:
undetectable		 1t9uA-2xuzA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		3 / 3 PHE A 300
VAL A 198
TRP A 209
 EB4  A 328 (-4.6A)
EB4  A 328 (-4.0A)
EB4  A 328 (-4.6A)
 0.91A 2cc8A-3tlkA:
undetectable		 2cc8A-3tlkA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		5 / 12 GLN A 192
LEU A 257
GLY A 259
ALA A 196
VAL A 198
 None
None
None
None
EB4  A 328 (-4.0A)
 1.00A 2oc8A-3tlkA:
undetectable		 2oc8A-3tlkA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		3 / 3 ASN A  77
ARG A  78
ASP A 268
 EB4  A 328 (-3.5A)
EB4  A 328 ( 3.5A)
None
 0.94A 2qe6A-3tlkA:
undetectable		 2qe6A-3tlkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		3 / 3 ASN A  77
ARG A  78
ASP A 268
 EB4  A 328 (-3.5A)
EB4  A 328 ( 3.5A)
None
 0.95A 2qe6B-3tlkA:
undetectable		 2qe6B-3tlkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		3 / 3 PHE A 300
VAL A 198
TRP A 209
 EB4  A 328 (-4.6A)
EB4  A 328 (-4.0A)
EB4  A 328 (-4.6A)
 0.90A 2vx9A-3tlkA:
undetectable		 2vx9A-3tlkA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 5 ASP A  49
SER A  46
SER A 103
VAL A 123
 None
None
EB4  A1300 ( 4.4A)
None
 1.06A 3rxhA-2xuzA:
undetectable		 3rxhA-2xuzA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 7 LYS A 105
ARG A 178
GLN A 277
GLU A  45
 EB4  A1300 ( 2.9A)
EB4  A1300 (-4.1A)
None
None
 1.26A 4mv7A-2xuzA:
5.5		 4mv7A-2xuzA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		3 / 3 ASN A  77
ASP A 127
GLY A 126
 EB4  A 328 (-3.5A)
EB4  A 328 (-3.5A)
EB4  A 328 (-3.4A)
 0.56A 5fctB-3tlkA:
undetectable		 5fctB-3tlkA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN
(Bacillus
subtilis) 		4 / 5 PRO A 274
ALA A 276
LYS A  84
GLN A 277
 None
None
EB4  A1300 ( 2.5A)
None
 1.20A 5odcA-2xuzA:
4.4
5odcG-2xuzA:
3.6		 5odcA-2xuzA:
18.50
5odcG-2xuzA:
18.50