SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EAX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		5 / 12 ILE A 195
ALA A 189
THR A 239
PRO A 220
ASN A 219
 None
None
None
None
EAX  A 401 (-2.8A)
 1.00A 1dhfA-4p9kA:
undetectable		 1dhfA-4p9kA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ILE A 195
ALA A 189
THR A 239
PRO A 220
ASN A 219
 None
None
None
None
EAX  A 401 (-2.8A)
 0.99A 1dhfA-4pdhA:
undetectable		 1dhfA-4pdhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4pdd TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 5 PHE A 226
SER A  74
THR A  40
PHE A 199
 None
None
EAX  A 401 (-3.2A)
EAX  A 401 (-4.2A)
 1.36A 1icuC-4pddA:
undetectable
1icuD-4pddA:
2.1		 1icuC-4pddA:
21.97
1icuD-4pddA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4pdd TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		3 / 3 TYR A  47
GLU A  79
ASN A 180
 EAX  A 401 (-4.1A)
EAX  A 401 (-3.0A)
None
 0.97A 2y7hC-4pddA:
undetectable		 2y7hC-4pddA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 8 GLU A  82
SER A  99
HIS A 186
ARG A 179
 EAX  A 401 (-3.0A)
None
None
EAX  A 401 (-3.0A)
 1.26A 3b9lA-4pdhA:
undetectable		 3b9lA-4pdhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		3 / 3 ASN A 219
ASP A 230
GLN A 231
 EAX  A 401 (-2.8A)
None
None
 0.79A 3eeyC-4p9kA:
undetectable		 3eeyC-4p9kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		3 / 3 ASN A 219
ASP A 230
GLN A 231
 EAX  A 401 (-2.8A)
None
None
 0.79A 3eeyD-4p9kA:
undetectable		 3eeyD-4p9kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		3 / 3 ASN A 219
ASP A 230
GLN A 231
 EAX  A 401 (-2.8A)
None
None
 0.79A 3eeyE-4p9kA:
undetectable		 3eeyE-4p9kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 7 GLY A 273
THR A 274
SER A  48
THR A  44
 None
None
None
EAX  A 401 ( 4.5A)
 0.75A 4ac9C-4pdhA:
undetectable		 4ac9C-4pdhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 11 HIS A  49
GLN A  50
ILE A  42
GLY A  81
GLY A  80
 None
EAX  A 401 (-3.2A)
None
None
None
 1.44A 4fglA-4pdhA:
undetectable
4fglB-4pdhA:
undetectable		 4fglA-4pdhA:
21.75
4fglB-4pdhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		4 / 7 MET A 181
HIS A  49
GLY A 156
ASN A 155
 EAX  A 401 (-3.3A)
None
None
EAX  A 401 (-3.4A)
 1.37A 5a5zC-4p9kA:
undetectable		 5a5zC-4p9kA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 7 MET A 181
HIS A  49
GLY A 156
ASN A 155
 EAX  A 401 (-3.3A)
None
None
EAX  A 401 (-3.4A)
 1.36A 5a5zC-4pdhA:
undetectable		 5a5zC-4pdhA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 VAL A 281
MET A 181
GLY A 102
VAL A 104
PHE A 142
 None
EAX  A 401 (-3.3A)
None
None
None
 1.08A 6brdC-4pdhA:
undetectable		 6brdC-4pdhA:
14.48