SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EAQ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
GLY A 168
VAL A 175
ALA A 189
VAL A 225
ASN A 293
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
None
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.76A 1fmoE-6fyoA:
25.4		 1fmoE-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 VAL A 209
VAL A 225
ILE A 239
LEU A 295
 None
None
None
EAQ  A 501 (-4.9A)
 0.89A 1iepB-6fyoA:
21.5		 1iepB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.63A 1opjB-6fyoA:
21.2		 1opjB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
GLU A 206
LEU A 210
GLY A 245
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 1.27A 1t46A-6fyoA:
22.3		 1t46A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
GLU A 206
LEU A 210
VAL A 225
GLY A 245
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.4A)
None
None
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.6A)
 1.16A 1t46A-6fyoA:
22.3		 1t46A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
GLY A 245
LEU A 295
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
 1.10A 1t46A-6fyoA:
22.3		 1t46A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
VAL A 225
GLY A 245
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
None
EAQ  A 501 (-3.9A)
 0.91A 1t46A-6fyoA:
22.3		 1t46A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 VAL A 175
LYS A 191
VAL A 225
PHE A 241
ASN A 293
LEU A 295
ASP A 325
 None
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-3.5A)
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.66A 2eufB-6fyoA:
31.1		 2eufB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.63A 2hyyB-6fyoA:
21.9		 2hyyB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
None
None
 0.75A 2hyyB-6fyoA:
21.9		 2hyyB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.66A 2hyyC-6fyoA:
21.9		 2hyyC-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 10 VAL A 175
ALA A 189
PHE A 241
LEU A 243
ASP A 250
LEU A 295
 None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.5A)
EAQ  A 501 ( 4.9A)
None
EAQ  A 501 (-4.9A)
 0.62A 2y7jD-6fyoA:
27.7		 2y7jD-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 10 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
None
None
 0.65A 3cs9A-6fyoA:
21.4		 3cs9A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 10 LEU A 167
VAL A 175
VAL A 225
ILE A 239
VAL A 323
 EAQ  A 501 (-3.9A)
None
None
None
None
 0.61A 3cs9A-6fyoA:
21.4		 3cs9A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 10 LEU A 167
VAL A 225
ILE A 239
VAL A 323
ASP A 325
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-4.6A)
 0.96A 3cs9A-6fyoA:
21.4		 3cs9A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 9 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
LEU A 295
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
None
None
EAQ  A 501 (-4.9A)
 0.90A 3cs9B-6fyoA:
21.6		 3cs9B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 9 LEU A 167
VAL A 175
VAL A 225
ILE A 239
LEU A 295
VAL A 323
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-4.9A)
None
 0.75A 3cs9B-6fyoA:
21.6		 3cs9B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 9 LEU A 167
VAL A 175
LYS A 191
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
None
None
 0.66A 3cs9C-6fyoA:
21.5		 3cs9C-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 9 LEU A 167
VAL A 175
VAL A 225
ILE A 239
VAL A 323
 EAQ  A 501 (-3.9A)
None
None
None
None
 0.60A 3cs9C-6fyoA:
21.5		 3cs9C-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 12 LEU A 210
GLU A 206
LEU A 284
LEU A 279
HIS A 286
 None
EAQ  A 501 (-3.4A)
None
None
None
 1.25A 3g1uA-6fyoA:
undetectable		 3g1uA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.65A 3ik3A-6fyoA:
21.4		 3ik3A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.64A 3ik3B-6fyoA:
21.2		 3ik3B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.64A 3k5vA-6fyoA:
21.1		 3k5vA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
None
None
 0.74A 3k5vA-6fyoA:
21.1		 3k5vA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
LYS A 191
VAL A 209
ILE A 239
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
 0.67A 3k5vB-6fyoA:
21.0		 3k5vB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LEU A 167
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.9A)
None
None
None
 0.82A 3k5vB-6fyoA:
21.0		 3k5vB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LYS A 191
SER A 247
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-4.9A)
 0.70A 3lxnA-6fyoA:
24.4		 3lxnA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LYS A 191
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.2A)
None
None
None
 0.79A 3mssA-6fyoA:
21.5		 3mssA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 LYS A 191
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.2A)
None
None
None
 0.81A 3mssB-6fyoA:
21.4		 3mssB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 6 VAL A 175
LYS A 191
VAL A 209
VAL A 225
ILE A 239
 None
EAQ  A 501 (-3.2A)
None
None
None
 0.76A 3mssD-6fyoA:
21.4		 3mssD-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 VAL A 175
ALA A 189
LYS A 191
GLU A 206
VAL A 209
ILE A 239
LEU A 295
 None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
None
EAQ  A 501 (-4.9A)
 0.91A 3oezB-6fyoA:
22.0		 3oezB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 9 LEU A 167
LYS A 191
VAL A 209
ILE A 239
LEU A 295
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.2A)
None
None
EAQ  A 501 (-4.9A)
 0.90A 3oxzA-6fyoA:
21.6		 3oxzA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 9 LEU A 167
VAL A 209
ILE A 239
LEU A 295
VAL A 323
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-4.9A)
None
 0.93A 3oxzA-6fyoA:
21.6		 3oxzA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 6 LYS A 191
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.2A)
None
None
None
 0.72A 3pyyA-6fyoA:
21.2		 3pyyA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 8 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.6A)
 0.51A 3warA-6fyoA:
29.1		 3warA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		9 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
GLY A 245
LEU A 279
HIS A 286
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
None
None
 1.26A 4asdA-6fyoA:
21.8		 4asdA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 12 ILE A 294
LEU A 244
GLU A 242
PHE A 326
HIS A 286
 None
EAQ  A 501 (-4.3A)
None
None
None
 1.12A 4b9zA-6fyoA:
undetectable		 4b9zA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 10 LEU A 167
GLY A 168
GLY A 170
VAL A 175
ALA A 189
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-4.9A)
 0.37A 4ckjA-6fyoA:
25.7		 4ckjA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 10 LEU A 167
GLY A 168
GLY A 170
VAL A 175
ALA A 189
SER A 247
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-3.6A)
None
 0.38A 4ckjA-6fyoA:
25.7		 4ckjA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LYS A 191
ASP A 250
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.79A 4i22A-6fyoA:
20.9		 4i22A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 11 VAL A 175
ALA A 189
LYS A 191
GLU A 292
LEU A 295
ASP A 325
 None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.97A 4iaaA-6fyoA:
25.0		 4iaaA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
ILE A 239
GLY A 245
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
 0.64A 4mxoA-6fyoA:
24.0		 4mxoA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
ILE A 239
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.81A 4mxyA-6fyoA:
24.4		 4mxyA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
ILE A 239
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.81A 4mxzA-6fyoA:
24.4		 4mxzA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 11 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LYS A 191
ASN A 293
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-4.9A)
 0.68A 4o0sA-6fyoA:
26.7		 4o0sA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 6 LEU A 167
GLY A 168
VAL A 175
ALA A 189
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-4.9A)
 0.52A 4o0wA-6fyoA:
25.3		 4o0wA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
GLY A 168
GLY A 173
VAL A 175
ALA A 189
LYS A 191
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-4.9A)
 0.50A 4otiA-6fyoA:
21.0		 4otiA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 243
GLY A 245
LEU A 295
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
 1.18A 4wkqA-6fyoA:
23.7		 4wkqA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 12 LEU A 167
VAL A 175
ALA A 189
ILE A 239
LEU A 243
LEU A 295
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
None
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-4.9A)
 0.54A 5h2uD-6fyoA:
21.3		 5h2uD-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 12 VAL A 175
ALA A 189
LYS A 191
ILE A 239
ASP A 250
GLY A 327
 None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
None
None
None
 0.97A 5hesB-6fyoA:
20.7		 5hesB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 ALA A 189
LYS A 191
GLU A 206
ILE A 239
GLY A 245
GLU A 254
LEU A 295
 EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-4.9A)
 1.29A 5i9xA-6fyoA:
22.7		 5i9xA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 7 GLY A 168
GLY A 170
VAL A 175
LYS A 191
ASP A 325
 None
None
None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-4.6A)
 0.70A 5j5xA-6fyoA:
25.7		 5j5xA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		6 / 12 GLY A 168
VAL A 175
ALA A 189
VAL A 225
PHE A 241
LEU A 295
 None
None
EAQ  A 501 (-3.6A)
None
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.9A)
 0.64A 5l2iA-6fyoA:
9.9		 5l2iA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 10 LEU A 167
VAL A 175
LYS A 191
GLU A 206
ILE A 239
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
 0.42A 5mo4A-6fyoA:
18.8		 5mo4A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 4 VAL A 225
LEU A 243
ASN A 293
ASP A 325
 None
EAQ  A 501 ( 4.9A)
None
EAQ  A 501 (-4.6A)
 0.95A 5vcyA-6fyoA:
26.7		 5vcyA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 12 LEU A 167
GLY A 168
VAL A 175
ALA A 189
PHE A 241
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.5A)
 0.13A 5xv7A-6fyoA:
35.7		 5xv7A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		5 / 12 LEU A 167
VAL A 175
ALA A 189
PHE A 241
GLY A 245
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-3.9A)
 0.58A 5xv7A-6fyoA:
35.7		 5xv7A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
LEU A 243
GLY A 245
LEU A 295
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
 0.87A 5y7zA-6fyoA:
25.0		 5y7zA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 243
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.87A 5y7zB-6fyoA:
25.2		 5y7zB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		7 / 12 LEU A 167
ALA A 189
LYS A 191
LEU A 243
GLY A 245
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.97A 5y7zB-6fyoA:
25.2		 5y7zB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		8 / 12 LEU A 167
VAL A 175
ALA A 189
LYS A 191
LEU A 243
GLY A 245
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 1.00A 5y80A-6fyoA:
23.9		 5y80A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 8 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.6A)
 0.35A 5y9mX-6fyoA:
22.3		 5y9mX-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.6A)
 0.54A 5yf9B-6fyoA:
27.9		 5yf9B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens) 		4 / 7 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.6A)
 0.50A 5ywmX-6fyoA:
27.8		 5ywmX-6fyoA:
undetectable