SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EAM'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LD6_B_KKKB602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	5 / 12	PHE A 145 TYR A 113 GLY A 109 ILE A 162 MET A 148	None None None EAM A1188 (-3.8A) None	1.49A	3ld6B-2yekA: undetectable	3ld6B-2yekA: 15.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3U5J_A_08HA1_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	7 / 7	TRP A 97 PRO A 98 LEU A 108 LEU A 110 ASN A 156 ILE A 162 MET A 165	None EAM A1188 (-4.6A) EAM A1188 ( 3.8A) EAM A1188 (-4.5A) EAM A1188 (-3.2A) EAM A1188 (-3.8A) EAM A1188 ( 4.1A)	0.47A	3u5jA-2yekA: 20.4	3u5jA-2yekA: 70.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3U5K_A_08JA1_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	8 / 8	TRP A 97 PRO A 98 VAL A 103 LEU A 108 LEU A 110 ASN A 156 ILE A 162 MET A 165	None EAM A1188 (-4.6A) EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 (-4.5A) EAM A1188 (-3.2A) EAM A1188 (-3.8A) EAM A1188 ( 4.1A)	0.39A	3u5kA-2yekA: 20.6	3u5kA-2yekA: 70.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3U5K_B_08JB2_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	7 / 7	TRP A 97 PRO A 98 VAL A 103 LEU A 108 LEU A 110 ASN A 156 ILE A 162	None EAM A1188 (-4.6A) EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 (-4.5A) EAM A1188 (-3.2A) EAM A1188 (-3.8A)	0.39A	3u5kB-2yekA: 20.3	3u5kB-2yekA: 70.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3U5K_C_08JC3_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	8 / 8	TRP A 97 PRO A 98 VAL A 103 LEU A 108 LEU A 110 ASN A 156 ILE A 162 MET A 165	None EAM A1188 (-4.6A) EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 (-4.5A) EAM A1188 (-3.2A) EAM A1188 (-3.8A) EAM A1188 ( 4.1A)	0.43A	3u5kC-2yekA: 19.7	3u5kC-2yekA: 70.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3U5K_D_08JD4_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	8 / 8	TRP A 97 PRO A 98 VAL A 103 LEU A 108 LEU A 110 ASN A 156 ILE A 162 MET A 165	None EAM A1188 (-4.6A) EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 (-4.5A) EAM A1188 (-3.2A) EAM A1188 (-3.8A) EAM A1188 ( 4.1A)	0.56A	3u5kD-2yekA: 20.5	3u5kD-2yekA: 70.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4A9J_A_TYLA1188_1 (BROMODOMAIN CONTAINING 2)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	5 / 5	VAL A 103 LEU A 108 LEU A 110 ASN A 156 ILE A 162	EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 (-4.5A) EAM A1188 (-3.2A) EAM A1188 (-3.8A)	0.40A	4a9jA-2yekA: 23.3	4a9jA-2yekA: 99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4A9J_B_TYLB1187_1 (BROMODOMAIN CONTAINING 2)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	5 / 5	VAL A 103 LEU A 108 LEU A 110 ASN A 156 ILE A 162	EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 (-4.5A) EAM A1188 (-3.2A) EAM A1188 (-3.8A)	0.43A	4a9jB-2yekA: 22.6	4a9jB-2yekA: 99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4A9J_C_TYLC1184_1 (BROMODOMAIN CONTAINING 2)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	5 / 5	VAL A 103 LEU A 108 LEU A 110 ASN A 156 ILE A 162	EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 (-4.5A) EAM A1188 (-3.2A) EAM A1188 (-3.8A)	0.34A	4a9jC-2yekA: 21.5	4a9jC-2yekA: 99.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4A9K_A_TYLA2200_1 (CREB-BINDING PROTEIN)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	4 / 6	VAL A 103 LEU A 108 TYR A 155 ASN A 156	EAM A1188 (-4.4A) EAM A1188 ( 3.8A) None EAM A1188 (-3.2A)	0.47A	4a9kA-2yekA: 17.8	4a9kA-2yekA: 34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	8 / 9	TRP A 97 PRO A 98 VAL A 103 LEU A 108 LEU A 110 ASN A 156 ILE A 162 MET A 165	None EAM A1188 (-4.6A) EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 (-4.5A) EAM A1188 (-3.2A) EAM A1188 (-3.8A) EAM A1188 ( 4.1A)	0.47A	4c66A-2yekA: 20.4	4c66A-2yekA: 69.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	5 / 9	VAL A 103 LEU A 108 ASN A 156 ILE A 162 MET A 165	EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 (-3.2A) EAM A1188 (-3.8A) EAM A1188 ( 4.1A)	1.43A	4c66A-2yekA: 20.4	4c66A-2yekA: 69.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4LZR_A_LOCA201_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	6 / 8	TRP A 97 VAL A 103 LEU A 108 LEU A 110 TYR A 155 ILE A 162	None EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 (-4.5A) None EAM A1188 (-3.8A)	0.56A	4lzrA-2yekA: 20.2	4lzrA-2yekA: 66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4LZR_A_LOCA201_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	7 / 8	TRP A 97 VAL A 103 LEU A 110 TYR A 155 ASN A 156 ASP A 160 ILE A 162	None EAM A1188 (-4.4A) EAM A1188 (-4.5A) None EAM A1188 (-3.2A) None EAM A1188 (-3.8A)	0.61A	4lzrA-2yekA: 20.2	4lzrA-2yekA: 66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4LZR_A_LOCA201_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	5 / 8	VAL A 103 LEU A 108 ASN A 156 ASP A 160 ILE A 162	EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 (-3.2A) None EAM A1188 (-3.8A)	1.11A	4lzrA-2yekA: 20.2	4lzrA-2yekA: 66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y03_A_SALA801_1 (PROTEIN POLYBROMO-1)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	4 / 7	TYR A 113 MET A 148 ASN A 156 ILE A 162	None None EAM A1188 (-3.2A) EAM A1188 (-3.8A)	0.64A	4y03A-2yekA: 15.0	4y03A-2yekA: 29.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5PBE_A_TYLA2001_1 (BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	5 / 6	PRO A 98 VAL A 103 TYR A 113 ASN A 156 ILE A 162	EAM A1188 (-4.6A) EAM A1188 (-4.4A) None EAM A1188 (-3.2A) EAM A1188 (-3.8A)	0.88A	5pbeA-2yekA: 16.2	5pbeA-2yekA: 32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y1Y_A_HNQA201_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	7 / 8	PRO A 98 VAL A 103 LEU A 108 CYH A 152 TYR A 155 ASN A 156 ILE A 162	EAM A1188 (-4.6A) EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 ( 4.3A) None EAM A1188 (-3.2A) EAM A1188 (-3.8A)	0.42A	5y1yA-2yekA: 19.9	5y1yA-2yekA: 68.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y1Y_A_HNQA201_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	7 / 8	PRO A 98 VAL A 103 LEU A 108 LEU A 110 CYH A 152 TYR A 155 ASN A 156	EAM A1188 (-4.6A) EAM A1188 (-4.4A) EAM A1188 ( 3.8A) EAM A1188 (-4.5A) EAM A1188 ( 4.3A) None EAM A1188 (-3.2A)	0.40A	5y1yA-2yekA: 19.9	5y1yA-2yekA: 68.61

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3LD6_B_KKKB602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"PHE A 145;TYR A 113;GLY A 109;ILE A 162;MET A 148","None;None;None;EAM A1188 (-3.8A);None","1.49A","3ld6B-2yekA:undetectable",null],["3U5J_A_08HA1_1","BROMODOMAIN-CONTAINING PROTEIN 4","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",7,"TRP A  97;PRO A  98;LEU A 108;LEU A 110;ASN A 156;ILE A 162;MET A 165","None;EAM A1188 (-4.6A);EAM A1188 ( 3.8A);EAM A1188 (-4.5A);EAM A1188 (-3.2A);EAM A1188 (-3.8A);EAM A1188 ( 4.1A)","0.47A","3u5jA-2yekA:20.4","3ld6B-2yekA:15.98"],["3U5K_A_08JA1_1","BROMODOMAIN-CONTAINING PROTEIN 4","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",8,"TRP A  97;PRO A  98;VAL A 103;LEU A 108;LEU A 110;ASN A 156;ILE A 162;MET A 165","None;EAM A1188 (-4.6A);EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 (-4.5A);EAM A1188 (-3.2A);EAM A1188 (-3.8A);EAM A1188 ( 4.1A)","0.39A","3u5kA-2yekA:20.6","3u5jA-2yekA:70.07"],["3U5K_B_08JB2_1","BROMODOMAIN-CONTAINING PROTEIN 4","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",7,"TRP A  97;PRO A  98;VAL A 103;LEU A 108;LEU A 110;ASN A 156;ILE A 162","None;EAM A1188 (-4.6A);EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 (-4.5A);EAM A1188 (-3.2A);EAM A1188 (-3.8A)","0.39A","3u5kB-2yekA:20.3","3u5kA-2yekA:70.07"],["3U5K_C_08JC3_1","BROMODOMAIN-CONTAINING PROTEIN 4","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",8,"TRP A  97;PRO A  98;VAL A 103;LEU A 108;LEU A 110;ASN A 156;ILE A 162;MET A 165","None;EAM A1188 (-4.6A);EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 (-4.5A);EAM A1188 (-3.2A);EAM A1188 (-3.8A);EAM A1188 ( 4.1A)","0.43A","3u5kC-2yekA:19.7","3u5kB-2yekA:70.07"],["3U5K_D_08JD4_1","BROMODOMAIN-CONTAINING PROTEIN 4","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",8,"TRP A  97;PRO A  98;VAL A 103;LEU A 108;LEU A 110;ASN A 156;ILE A 162;MET A 165","None;EAM A1188 (-4.6A);EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 (-4.5A);EAM A1188 (-3.2A);EAM A1188 (-3.8A);EAM A1188 ( 4.1A)","0.56A","3u5kD-2yekA:20.5","3u5kC-2yekA:70.07"],["4A9J_A_TYLA1188_1","BROMODOMAIN CONTAINING 2","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"VAL A 103;LEU A 108;LEU A 110;ASN A 156;ILE A 162","EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 (-4.5A);EAM A1188 (-3.2A);EAM A1188 (-3.8A)","0.40A","4a9jA-2yekA:23.3","3u5kD-2yekA:70.07"],["4A9J_B_TYLB1187_1","BROMODOMAIN CONTAINING 2","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"VAL A 103;LEU A 108;LEU A 110;ASN A 156;ILE A 162","EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 (-4.5A);EAM A1188 (-3.2A);EAM A1188 (-3.8A)","0.43A","4a9jB-2yekA:22.6","4a9jA-2yekA:99.35"],["4A9J_C_TYLC1184_1","BROMODOMAIN CONTAINING 2","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"VAL A 103;LEU A 108;LEU A 110;ASN A 156;ILE A 162","EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 (-4.5A);EAM A1188 (-3.2A);EAM A1188 (-3.8A)","0.34A","4a9jC-2yekA:21.5","4a9jB-2yekA:99.35"],["4A9K_A_TYLA2200_1","CREB-BINDING PROTEIN","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",4,"VAL A 103;LEU A 108;TYR A 155;ASN A 156","EAM A1188 (-4.4A);EAM A1188 ( 3.8A);None;EAM A1188 (-3.2A)","0.47A","4a9kA-2yekA:17.8","4a9jC-2yekA:99.35"],["4C66_A_H4CA1168_0","BROMODOMAIN-CONTAINING PROTEIN 4","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",8,"TRP A  97;PRO A  98;VAL A 103;LEU A 108;LEU A 110;ASN A 156;ILE A 162;MET A 165","None;EAM A1188 (-4.6A);EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 (-4.5A);EAM A1188 (-3.2A);EAM A1188 (-3.8A);EAM A1188 ( 4.1A)","0.47A","4c66A-2yekA:20.4","4a9kA-2yekA:34.09"],["4C66_A_H4CA1168_0","BROMODOMAIN-CONTAINING PROTEIN 4","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"VAL A 103;LEU A 108;ASN A 156;ILE A 162;MET A 165","EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 (-3.2A);EAM A1188 (-3.8A);EAM A1188 ( 4.1A)","1.43A","4c66A-2yekA:20.4","4c66A-2yekA:69.85"],["4LZR_A_LOCA201_1","BROMODOMAIN-CONTAINING PROTEIN 4","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",6,"TRP A  97;VAL A 103;LEU A 108;LEU A 110;TYR A 155;ILE A 162","None;EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 (-4.5A);None;EAM A1188 (-3.8A)","0.56A","4lzrA-2yekA:20.2","4c66A-2yekA:69.85"],["4LZR_A_LOCA201_1","BROMODOMAIN-CONTAINING PROTEIN 4","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",7,"TRP A  97;VAL A 103;LEU A 110;TYR A 155;ASN A 156;ASP A 160;ILE A 162","None;EAM A1188 (-4.4A);EAM A1188 (-4.5A);None;EAM A1188 (-3.2A);None;EAM A1188 (-3.8A)","0.61A","4lzrA-2yekA:20.2","4lzrA-2yekA:66.67"],["4LZR_A_LOCA201_1","BROMODOMAIN-CONTAINING PROTEIN 4","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"VAL A 103;LEU A 108;ASN A 156;ASP A 160;ILE A 162","EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 (-3.2A);None;EAM A1188 (-3.8A)","1.11A","4lzrA-2yekA:20.2","4lzrA-2yekA:66.67"],["4Y03_A_SALA801_1","PROTEIN POLYBROMO-1","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",4,"TYR A 113;MET A 148;ASN A 156;ILE A 162","None;None;EAM A1188 (-3.2A);EAM A1188 (-3.8A)","0.64A","4y03A-2yekA:15.0","4lzrA-2yekA:66.67"],["5PBE_A_TYLA2001_1","BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"PRO A  98;VAL A 103;TYR A 113;ASN A 156;ILE A 162","EAM A1188 (-4.6A);EAM A1188 (-4.4A);None;EAM A1188 (-3.2A);EAM A1188 (-3.8A)","0.88A","5pbeA-2yekA:16.2","4y03A-2yekA:29.11"],["5Y1Y_A_HNQA201_1","BROMODOMAIN-CONTAINING PROTEIN 4","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",7,"PRO A  98;VAL A 103;LEU A 108;CYH A 152;TYR A 155;ASN A 156;ILE A 162","EAM A1188 (-4.6A);EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 ( 4.3A);None;EAM A1188 (-3.2A);EAM A1188 (-3.8A)","0.42A","5y1yA-2yekA:19.9","5pbeA-2yekA:32.08"],["5Y1Y_A_HNQA201_1","BROMODOMAIN-CONTAINING PROTEIN 4","2yek","BROMODOMAIN-CONTAINING PROTEIN 2","Homo sapiens",7,"PRO A  98;VAL A 103;LEU A 108;LEU A 110;CYH A 152;TYR A 155;ASN A 156","EAM A1188 (-4.6A);EAM A1188 (-4.4A);EAM A1188 ( 3.8A);EAM A1188 (-4.5A);EAM A1188 ( 4.3A);None;EAM A1188 (-3.2A)","0.40A","5y1yA-2yekA:19.9","5y1yA-2yekA:68.61"]]