SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'E67'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_A_SAMA2001_0 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	3u78	LYSINE-SPECIFIC DEMETHYLASE 7 (Homo sapiens)	5 / 12	PHE A 285 VAL A 290 ALA A 355 PHE A 281 TYR A 314	E67 A 707 (-4.3A) None None None None	1.31A	2g72A-3u78A: undetectable	2g72A-3u78A: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GN0_A_DMOA551_1 (ARGINASE-1)	3u78	LYSINE-SPECIFIC DEMETHYLASE 7 (Homo sapiens)	5 / 9	HIS A 282 ASP A 284 SER A 227 ASP A 392 THR A 279	NI A 702 ( 3.4A) NI A 702 (-2.6A) None E67 A 707 (-3.4A) AKG A 701 (-3.6A)	1.47A	3gn0A-3u78A: undetectable	3gn0A-3u78A: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BEC_C_RBTC601_1 (SCAFFOLD PROTEIN D13)	3u78	LYSINE-SPECIFIC DEMETHYLASE 7 (Homo sapiens)	5 / 12	VAL A 179 VAL A 356 PHE A 214 GLN A 200 ILE A 300	None AKG A 701 (-4.1A) None E67 A 707 (-3.3A) None	1.37A	6becA-3u78A: undetectable 6becB-3u78A: undetectable 6becC-3u78A: undetectable	6becA-3u78A: 21.05 6becB-3u78A: 21.05 6becC-3u78A: 21.05

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2G72_A_SAMA2001_0","PHENYLETHANOLAMINE N-METHYLTRANSFERASE","3u78","LYSINE-SPECIFIC DEMETHYLASE 7","Homo sapiens",5,"PHE A 285;VAL A 290;ALA A 355;PHE A 281;TYR A 314","E67 A 707 (-4.3A);None;None;None;None","1.31A","2g72A-3u78A:undetectable",null],["3GN0_A_DMOA551_1","ARGINASE-1","3u78","LYSINE-SPECIFIC DEMETHYLASE 7","Homo sapiens",5,"HIS A 282;ASP A 284;SER A 227;ASP A 392;THR A 279"," NI A 702 ( 3.4A); NI A 702 (-2.6A);None;E67 A 707 (-3.4A);AKG A 701 (-3.6A)","1.47A","3gn0A-3u78A:undetectable","2g72A-3u78A:21.33"],["6BEC_C_RBTC601_1","SCAFFOLD PROTEIN D13;SCAFFOLD PROTEIN D13;SCAFFOLD PROTEIN D13","3u78","LYSINE-SPECIFIC DEMETHYLASE 7","Homo sapiens",5,"VAL A 179;VAL A 356;PHE A 214;GLN A 200;ILE A 300","None;AKG A 701 (-4.1A);None;E67 A 707 (-3.3A);None","1.37A","6becA-3u78A:undetectable;6becB-3u78A:undetectable;6becC-3u78A:undetectable","3gn0A-3u78A:22.53"]]