SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'E64'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1aec ACTINIDIN
(Actinidia
chinensis) 		7 / 10 GLN A  19
GLY A  23
TRP A  26
PHE A  28
SER A  29
HIS A 162
ALA A 163
 E64  A 219 (-3.2A)
E64  A 219 (-3.2A)
None
None
None
E64  A 219 (-3.8A)
E64  A 219 ( 4.3A)
 0.30A 1stfE-1aecA:
36.9
1stfI-1aecA:
0.0		 1stfE-1aecA:
47.49
1stfI-1aecA:
16.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 2bdz MEXICAIN
(Jacaratia
mexicana) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 160
GLY A  65
 E64  A 501 (-3.3A)
E64  A 501 (-3.2A)
None
None
None
E64  A 501 ( 4.6A)
E64  A 501 (-3.0A)
 1.21A 1stfE-2bdzA:
38.4
1stfI-2bdzA:
1.4		 1stfE-2bdzA:
59.62
1stfI-2bdzA:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 2bdz MEXICAIN
(Jacaratia
mexicana) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 159
ALA A 160
 E64  A 501 (-3.3A)
E64  A 501 (-3.2A)
None
None
None
None
E64  A 501 (-4.1A)
E64  A 501 ( 4.6A)
 0.39A 1stfE-2bdzA:
38.4
1stfI-2bdzA:
1.4		 1stfE-2bdzA:
59.62
1stfI-2bdzA:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3bcn ERVATAMIN-A
(Tabernaemontana
divaricata) 		6 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
HIS A 157
 E64  A 214 (-3.9A)
E64  A 214 (-2.5A)
None
E64  A 214 (-4.8A)
None
E64  A 214 (-4.3A)
 0.28A 1stfE-3bcnA:
22.8
1stfI-3bcnA:
undetectable		 1stfE-3bcnA:
50.23
1stfI-3bcnA:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3bcn ERVATAMIN-A
(Tabernaemontana
divaricata) 		6 / 10 GLN A  19
GLY A  23
TRP A  26
PHE A  28
SER A  29
HIS A 157
 E64  A 214 (-3.9A)
E64  A 214 (-2.5A)
E64  A 214 (-4.8A)
None
None
E64  A 214 (-4.3A)
 0.62A 1stfE-3bcnA:
22.8
1stfI-3bcnA:
undetectable		 1stfE-3bcnA:
50.23
1stfI-3bcnA:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3ioq CMS1MS2
(Vasconcellea
cundinamarcensis) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 160
GLY A  65
 E64  A 301 (-3.2A)
E64  A 301 ( 3.1A)
None
None
None
E64  A 301 ( 4.4A)
E64  A 301 (-3.3A)
 1.25A 1stfE-3ioqA:
39.4
1stfI-3ioqA:
0.9		 1stfE-3ioqA:
67.14
1stfI-3ioqA:
18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3ioq CMS1MS2
(Vasconcellea
cundinamarcensis) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 159
ALA A 160
 E64  A 301 (-3.2A)
E64  A 301 ( 3.1A)
None
E64  A 301 (-4.9A)
None
None
E64  A 301 (-3.8A)
E64  A 301 ( 4.4A)
 0.42A 1stfE-3ioqA:
39.4
1stfI-3ioqA:
0.9		 1stfE-3ioqA:
67.14
1stfI-3ioqA:
18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 5a24 DIONAIN-1
(Dionaea
muscipula) 		7 / 10 GLN A  20
GLY A  24
TRP A  27
PHE A  29
SER A  30
HIS A 165
ALA A 166
 E64  A1224 (-3.2A)
E64  A1224 (-3.1A)
E64  A1224 (-4.9A)
None
None
E64  A1224 (-3.8A)
E64  A1224 ( 4.0A)
 0.28A 1stfE-5a24A:
36.2
1stfI-5a24A:
undetectable		 1stfE-5a24A:
45.95
1stfI-5a24A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5mua RICIN B-RELATED
LECTIN
(Polyporus
squamosus) 		4 / 7 GLN A 268
ALA A 249
PHE A 206
ASN A 251
 E64  A 304 ( 4.9A)
E64  A 304 ( 4.3A)
None
None
 1.37A 1t9wA-5muaA:
undetectable		 1t9wA-5muaA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3ioq CMS1MS2
(Vasconcellea
cundinamarcensis) 		5 / 12 ILE A 171
ILE A 173
ALA A 163
ILE A 157
HIS A 159
 None
None
None
E64  A 301 ( 4.3A)
E64  A 301 (-3.8A)
 1.23A 1xzxX-3ioqA:
undetectable		 1xzxX-3ioqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		4 / 8 GLN A  18
GLY A  22
GLY A 107
MET A  70
 E64  A 176 (-3.3A)
E64  A 176 (-3.2A)
None
E64  A 176 ( 3.8A)
 0.88A 2y6rB-1cv8A:
undetectable		 2y6rB-1cv8A:
17.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1aec ACTINIDIN
(Actinidia
chinensis) 		4 / 7 GLN A  19
GLY A  23
HIS A 162
TRP A 184
 E64  A 219 (-3.2A)
E64  A 219 (-3.2A)
E64  A 219 (-3.8A)
None
 0.48A 3ai8A-1aecA:
27.6		 3ai8A-1aecA:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1aec ACTINIDIN
(Actinidia
chinensis) 		4 / 7 GLN A  19
GLY A  24
HIS A 162
TRP A 184
 E64  A 219 (-3.2A)
E64  A 219 (-4.1A)
E64  A 219 (-3.8A)
None
 0.88A 3ai8A-1aecA:
27.6		 3ai8A-1aecA:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		4 / 7 GLN A  18
GLY A  22
HIS A 120
TRP A 143
 E64  A 176 (-3.3A)
E64  A 176 (-3.2A)
E64  A 176 ( 3.7A)
None
 0.49A 3ai8A-1cv8A:
12.4		 3ai8A-1cv8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 2bdz MEXICAIN
(Jacaratia
mexicana) 		4 / 7 GLN A  19
GLY A  23
HIS A 159
TRP A 177
 E64  A 501 (-3.3A)
E64  A 501 (-3.2A)
E64  A 501 (-4.1A)
None
 0.42A 3ai8A-2bdzA:
27.3		 3ai8A-2bdzA:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3bcn ERVATAMIN-A
(Tabernaemontana
divaricata) 		4 / 7 GLN A  19
GLY A  23
HIS A 157
TRP A 175
 E64  A 214 (-3.9A)
E64  A 214 (-2.5A)
E64  A 214 (-4.3A)
None
 0.49A 3ai8A-3bcnA:
26.0		 3ai8A-3bcnA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3ioq CMS1MS2
(Vasconcellea
cundinamarcensis) 		4 / 7 GLN A  19
GLY A  23
HIS A 159
TRP A 177
 E64  A 301 (-3.2A)
E64  A 301 ( 3.1A)
E64  A 301 (-3.8A)
EDO  A 508 (-4.7A)
 0.44A 3ai8A-3ioqA:
27.4		 3ai8A-3ioqA:
27.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 5a24 DIONAIN-1
(Dionaea
muscipula) 		4 / 7 GLN A  20
GLY A  24
HIS A 165
TRP A 189
 E64  A1224 (-3.2A)
E64  A1224 (-3.1A)
E64  A1224 (-3.8A)
None
 0.50A 3ai8A-5a24A:
27.6		 3ai8A-5a24A:
30.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		3 / 3 LEU A  51
HIS A  52
MET A  48
 None
E64  A 176 (-4.4A)
None
 0.95A 3thrD-1cv8A:
undetectable		 3thrD-1cv8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		5 / 10 ALA A  25
PRO A  81
ILE A  71
LEU A  83
ILE A 171
 E64  A 176 ( 4.1A)
None
None
None
None
 1.33A 4dtaA-1cv8A:
undetectable		 4dtaA-1cv8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qx6 NPQTN SPECIFIC
SORTASE B
(Staphylococcus
aureus) 		4 / 7 ARG A 233
PHE A 114
ARG A 115
ASP A 113
 E64  A 245 (-2.3A)
E64  A 245 (-3.8A)
None
None
 1.49A 5a06A-1qx6A:
undetectable		 5a06A-1qx6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qx6 NPQTN SPECIFIC
SORTASE B
(Staphylococcus
aureus) 		4 / 7 ARG A 233
PHE A 114
ARG A 115
ASP A 113
 E64  A 245 (-2.3A)
E64  A 245 (-3.8A)
None
None
 1.48A 5a06C-1qx6A:
undetectable		 5a06C-1qx6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1qx6 NPQTN SPECIFIC
SORTASE B
(Staphylococcus
aureus) 		4 / 7 ARG A 233
PHE A 114
ARG A 115
ASP A 113
 E64  A 245 (-2.3A)
E64  A 245 (-3.8A)
None
None
 1.47A 5a06F-1qx6A:
undetectable		 5a06F-1qx6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 2bdz MEXICAIN
(Jacaratia
mexicana) 		5 / 12 VAL A 132
GLN A  68
ALA A 124
VAL A 130
LEU A  72
 None
E64  A 501 ( 4.8A)
None
None
None
 1.20A 5hv1A-2bdzA:
undetectable		 5hv1A-2bdzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5a24 DIONAIN-1
(Dionaea
muscipula) 		5 / 10 VAL A  55
GLY A  65
GLY A  68
TRP A  27
ALA A  94
 None
None
E64  A1224 (-3.4A)
E64  A1224 (-4.9A)
None
 1.03A 5vm8B-5a24A:
undetectable		 5vm8B-5a24A:
19.92