SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'E55'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M9Q_B_BEZB251_0 (SERINE PROTEASE INHIBITOR SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3)	2z65	LYMPHOCYTE ANTIGEN 96 (Homo sapiens)	5 / 9	ILE C 46 ILE C 63 PHE C 151 ALA C 137 LEU C 149	E55 C 1 (-4.6A) E55 C 1 ( 4.5A) E55 C 1 (-3.9A) None None	1.15A	2m9qA-2z65C: undetectable	2m9qA-2z65C: 19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVM_A_PFLA511_1 (PROTON-GATED ION CHANNEL)	2z65	LYMPHOCYTE ANTIGEN 96 (Homo sapiens)	4 / 8	ILE C 124 ILE C 52 ALA C 30 ILE C 153	E55 C 1 ( 4.9A) E55 C 1 ( 4.5A) None E55 C 1 ( 4.8A)	0.72A	5mvmA-2z65C: undetectable 5mvmB-2z65C: undetectable	5mvmA-2z65C: 22.82 5mvmB-2z65C: 22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_B_PCFB1802_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	2z65	LYMPHOCYTE ANTIGEN 96 (Homo sapiens)	4 / 7	THR C 115 PHE C 104 VAL C 113 ILE C 46	None E55 C 1 (-4.4A) None E55 C 1 (-4.6A)	1.08A	5vkqA-2z65C: undetectable 5vkqB-2z65C: undetectable	5vkqA-2z65C: 5.28 5vkqB-2z65C: 5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1803_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	2z65	LYMPHOCYTE ANTIGEN 96 (Homo sapiens)	4 / 8	THR C 115 PHE C 104 VAL C 113 ILE C 46	None E55 C 1 (-4.4A) None E55 C 1 (-4.6A)	1.07A	5vkqB-2z65C: undetectable 5vkqC-2z65C: undetectable	5vkqB-2z65C: 5.28 5vkqC-2z65C: 5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_D_PCFD1803_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	2z65	LYMPHOCYTE ANTIGEN 96 (Homo sapiens)	4 / 7	THR C 115 PHE C 104 VAL C 113 ILE C 46	None E55 C 1 (-4.4A) None E55 C 1 (-4.6A)	1.07A	5vkqC-2z65C: undetectable 5vkqD-2z65C: undetectable	5vkqC-2z65C: 5.28 5vkqD-2z65C: 5.28

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2M9Q_B_BEZB251_0","SERINE PROTEASE INHIBITOR;SERINE PROTEASE SUBUNIT NS2B, SERINE PROTEASE NS3","2z65","LYMPHOCYTE ANTIGEN 96","Homo sapiens",5,"ILE C  46;ILE C  63;PHE C 151;ALA C 137;LEU C 149","E55 C   1 (-4.6A);E55 C   1 ( 4.5A);E55 C   1 (-3.9A);None;None","1.15A","2m9qA-2z65C:undetectable",null],["5MVM_A_PFLA511_1","PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL","2z65","LYMPHOCYTE ANTIGEN 96","Homo sapiens",4,"ILE C 124;ILE C  52;ALA C  30;ILE C 153","E55 C   1 ( 4.9A);E55 C   1 ( 4.5A);None;E55 C   1 ( 4.8A)","0.72A","5mvmA-2z65C:undetectable;5mvmB-2z65C:undetectable","2m9qA-2z65C:19.75"],["5VKQ_B_PCFB1802_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","2z65","LYMPHOCYTE ANTIGEN 96","Homo sapiens",4,"THR C 115;PHE C 104;VAL C 113;ILE C  46","None;E55 C   1 (-4.4A);None;E55 C   1 (-4.6A)","1.08A","5vkqA-2z65C:undetectable;5vkqB-2z65C:undetectable","5mvmA-2z65C:22.82;5mvmB-2z65C:22.82"],["5VKQ_C_PCFC1803_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","2z65","LYMPHOCYTE ANTIGEN 96","Homo sapiens",4,"THR C 115;PHE C 104;VAL C 113;ILE C  46","None;E55 C   1 (-4.4A);None;E55 C   1 (-4.6A)","1.07A","5vkqB-2z65C:undetectable;5vkqC-2z65C:undetectable","5vkqA-2z65C:5.28;5vkqB-2z65C:5.28"],["5VKQ_D_PCFD1803_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","2z65","LYMPHOCYTE ANTIGEN 96","Homo sapiens",4,"THR C 115;PHE C 104;VAL C 113;ILE C  46","None;E55 C   1 (-4.4A);None;E55 C   1 (-4.6A)","1.07A","5vkqC-2z65C:undetectable;5vkqD-2z65C:undetectable","5vkqB-2z65C:5.28;5vkqC-2z65C:5.28"]]