SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'E2J'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.68A 2y00A-6bqhA:
31.3		 2y00A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
None
None
 1.10A 2y00A-6bqhA:
31.3		 2y00A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.4A)
None
 1.48A 2y00A-6bqhA:
31.3		 2y00A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.79A 2y00A-6bqhA:
31.3		 2y00A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 1.14A 2y00B-6bqhA:
31.3		 2y00B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.4A)
None
 1.50A 2y00B-6bqhA:
31.3		 2y00B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.83A 2y00B-6bqhA:
31.3		 2y00B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
PHE A 327
PHE A 328
ASN A 331
TRP A 355
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
None
 0.68A 2y01A-6bqhA:
31.1		 2y01A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
ASN A 331
TRP A 355
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
None
None
None
 1.17A 2y01A-6bqhA:
31.1		 2y01A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.74A 2y01B-6bqhA:
31.1		 2y01B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
None
None
 1.14A 2y01B-6bqhA:
31.1		 2y01B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.4A)
None
 1.44A 2y01B-6bqhA:
31.1		 2y01B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.78A 2y01B-6bqhA:
31.1		 2y01B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 1.04A 2y03A-6bqhA:
31.0		 2y03A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 1.23A 2y03A-6bqhA:
31.0		 2y03A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.68A 2y03A-6bqhA:
31.0		 2y03A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 1.03A 2y03B-6bqhA:
31.1		 2y03B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 1.25A 2y03B-6bqhA:
31.1		 2y03B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.67A 2y03B-6bqhA:
31.1		 2y03B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_A_68HA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 11 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 1.20A 2y04A-6bqhA:
31.1		 2y04A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_A_68HA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 11 TRP A 130
ASP A 134
SER A 219
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.4A)
None
 1.39A 2y04A-6bqhA:
31.1		 2y04A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_A_68HA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 11 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.75A 2y04A-6bqhA:
31.1		 2y04A-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 1.18A 2y04B-6bqhA:
31.1		 2y04B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.4A)
None
 1.39A 2y04B-6bqhA:
31.1		 2y04B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.72A 2y04B-6bqhA:
31.1		 2y04B-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
 1.32A 3d4sA-6bqhA:
30.8		 3d4sA-6bqhA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
TRP A 324
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
None
None
 0.57A 3d4sA-6bqhA:
30.8		 3d4sA-6bqhA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
VAL A 135
TRP A 324
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
None
 0.73A 3d4sA-6bqhA:
30.8		 3d4sA-6bqhA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
 1.17A 3nyaA-6bqhA:
30.8		 3nyaA-6bqhA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.4A)
None
 1.15A 3nyaA-6bqhA:
30.8		 3nyaA-6bqhA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.63A 3nyaA-6bqhA:
30.8		 3nyaA-6bqhA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 ASP A 134
SER A 138
THR A 139
ILE A 142
TRP A 324
PHE A 328
TYR A 358
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
E2J  A1201 (-3.5A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
None
 0.49A 3rzeA-6bqhA:
28.9		 3rzeA-6bqhA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
 1.31A 4amjA-6bqhA:
31.4		 4amjA-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
TRP A 324
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 ( 3.7A)
None
 1.18A 4amjA-6bqhA:
31.4		 4amjA-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
TRP A 324
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.61A 4amjA-6bqhA:
31.4		 4amjA-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
VAL A 135
TRP A 324
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.67A 4amjA-6bqhA:
31.4		 4amjA-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
 1.33A 4amjB-6bqhA:
31.6		 4amjB-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
SER A 219
TRP A 324
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
None
 1.39A 4amjB-6bqhA:
31.6		 4amjB-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
TRP A 324
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.63A 4amjB-6bqhA:
31.6		 4amjB-6bqhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		4 / 6 TRP A 130
THR A 139
VAL A 208
SER A 219
 None
E2J  A1201 (-4.3A)
None
E2J  A1201 (-3.2A)
 0.90A 4iaqA-6bqhA:
32.0		 4iaqA-6bqhA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		4 / 7 TRP A 130
THR A 139
VAL A 208
PHE A 328
 None
E2J  A1201 (-4.3A)
None
E2J  A1201 (-4.4A)
 0.82A 4iarA-6bqhA:
29.6		 4iarA-6bqhA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		4 / 7 TRP A 130
THR A 139
VAL A 208
SER A 219
 None
E2J  A1201 (-4.3A)
None
E2J  A1201 (-3.2A)
 0.82A 4iarA-6bqhA:
29.6		 4iarA-6bqhA:
9.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 SER A 138
ALA A 222
TRP A 324
PHE A 327
VAL A 335
VAL A 354
 E2J  A1201 (-3.2A)
E2J  A1201 ( 3.8A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
None
E2J  A1201 (-4.6A)
 0.94A 4ib4A-6bqhA:
31.9		 4ib4A-6bqhA:
62.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 SER A 138
TRP A 324
PHE A 327
PHE A 328
VAL A 335
VAL A 354
 E2J  A1201 (-3.2A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
E2J  A1201 (-4.6A)
 0.67A 4ib4A-6bqhA:
31.9		 4ib4A-6bqhA:
62.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 SER A 138
VAL A 208
ALA A 222
VAL A 335
VAL A 354
 E2J  A1201 (-3.2A)
None
E2J  A1201 ( 3.8A)
None
E2J  A1201 (-4.6A)
 1.18A 4ib4A-6bqhA:
31.9		 4ib4A-6bqhA:
62.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 VAL A 135
SER A 138
ALA A 222
TRP A 324
PHE A 327
VAL A 354
 E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 ( 3.8A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.6A)
 0.90A 4ib4A-6bqhA:
31.9		 4ib4A-6bqhA:
62.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 VAL A 135
SER A 138
TRP A 324
PHE A 327
PHE A 328
VAL A 354
 E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 (-4.6A)
 0.71A 4ib4A-6bqhA:
31.9		 4ib4A-6bqhA:
62.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 135
SER A 138
VAL A 208
ALA A 222
VAL A 354
 E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
None
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
 0.97A 4ib4A-6bqhA:
31.9		 4ib4A-6bqhA:
62.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ASP A 134
LEU A 209
ASN A 331
LEU A 350
 E2J  A1201 (-3.0A)
None
None
E2J  A1201 ( 4.3A)
 1.06A 4ib4A-6bqhA:
31.9		 4ib4A-6bqhA:
62.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ASP A 134
THR A 139
LEU A 209
LEU A 350
 E2J  A1201 (-3.0A)
E2J  A1201 (-4.3A)
None
E2J  A1201 ( 4.3A)
 1.01A 4ib4A-6bqhA:
31.9		 4ib4A-6bqhA:
62.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 10 ASP A 134
SER A 219
PHE A 327
ASN A 331
TYR A 358
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
None
None
 0.87A 4ldoA-6bqhA:
27.6		 4ldoA-6bqhA:
13.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 ASP A 134
VAL A 135
SER A 138
ALA A 222
TRP A 324
PHE A 327
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 ( 3.8A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.6A)
 0.87A 4nc3A-6bqhA:
31.8		 4nc3A-6bqhA:
62.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ASP A 134
VAL A 135
SER A 138
VAL A 208
ALA A 222
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
None
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
 0.94A 4nc3A-6bqhA:
31.8		 4nc3A-6bqhA:
62.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		8 / 12 ASP A 134
SER A 138
VAL A 208
ALA A 222
PHE A 327
PHE A 328
LEU A 350
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 4.3A)
E2J  A1201 (-4.6A)
 0.96A 5tudA-6bqhA:
31.5		 5tudA-6bqhA:
69.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		8 / 12 ASP A 134
VAL A 135
SER A 138
VAL A 208
ALA A 222
PHE A 327
PHE A 328
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
None
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 (-4.6A)
 0.96A 5tudA-6bqhA:
31.5		 5tudA-6bqhA:
69.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A 134
SER A 138
VAL A 208
ALA A 222
PHE A 327
PHE A 328
VAL A 335
LEU A 350
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
E2J  A1201 ( 4.3A)
E2J  A1201 (-4.6A)
 1.06A 5tudD-6bqhA:
31.9		 5tudD-6bqhA:
69.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A 134
SER A 138
VAL A 208
PHE A 327
PHE A 328
ASN A 331
VAL A 335
LEU A 350
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
E2J  A1201 ( 4.3A)
E2J  A1201 (-4.6A)
 0.93A 5tudD-6bqhA:
31.9		 5tudD-6bqhA:
69.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		11 / 12 SER A 110
TRP A 130
SER A 138
THR A 139
ILE A 142
PHE A 320
TRP A 324
PHE A 327
PHE A 328
LEU A 350
TYR A 358
 E2J  A1201 ( 4.5A)
None
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
E2J  A1201 (-3.5A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 4.3A)
None
 0.49A 6a93A-6bqhA:
36.7		 6a93A-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		10 / 12 SER A 110
TRP A 130
VAL A 135
SER A 138
THR A 139
TRP A 324
PHE A 327
PHE A 328
LEU A 350
VAL A 354
 E2J  A1201 ( 4.5A)
None
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 4.3A)
E2J  A1201 (-4.6A)
 0.58A 6a93B-6bqhA:
37.6		 6a93B-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		10 / 12 SER A 110
TYR A 118
TRP A 130
VAL A 135
THR A 139
TRP A 324
PHE A 327
PHE A 328
LEU A 350
VAL A 354
 E2J  A1201 ( 4.5A)
None
None
E2J  A1201 (-3.8A)
E2J  A1201 (-4.3A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 4.3A)
E2J  A1201 (-4.6A)
 0.68A 6a93B-6bqhA:
37.6		 6a93B-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 5 ASP A 134
ILE A 142
PHE A 320
ASN A 351
TYR A 358
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.5A)
E2J  A1201 (-4.4A)
E2J  A1201 (-3.8A)
None
 0.47A 6a93B-6bqhA:
37.6		 6a93B-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
SER A 138
LEU A 209
VAL A 215
GLY A 218
PHE A 320
TRP A 324
 None
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
 0.87A 6a94A-6bqhA:
36.1		 6a94A-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		9 / 12 TRP A 130
SER A 138
LEU A 209
VAL A 215
PHE A 320
TRP A 324
PHE A 327
PHE A 328
VAL A 354
 None
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 (-4.6A)
 0.78A 6a94A-6bqhA:
36.1		 6a94A-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
SER A 138
VAL A 215
GLY A 218
PHE A 320
TRP A 324
ASN A 331
 None
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
None
 1.00A 6a94A-6bqhA:
36.1		 6a94A-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		9 / 12 TRP A 130
SER A 138
VAL A 215
PHE A 320
TRP A 324
PHE A 327
PHE A 328
ASN A 331
VAL A 354
 None
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
E2J  A1201 (-4.6A)
 0.80A 6a94A-6bqhA:
36.1		 6a94A-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		10 / 12 VAL A 135
SER A 138
THR A 139
LEU A 209
VAL A 215
GLY A 218
PHE A 320
TRP A 324
PHE A 327
VAL A 354
 E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.6A)
 0.85A 6a94B-6bqhA:
37.5		 6a94B-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		10 / 12 VAL A 135
SER A 138
THR A 139
LEU A 209
VAL A 215
PHE A 320
TRP A 324
PHE A 327
PHE A 328
VAL A 354
 E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 (-4.6A)
 0.76A 6a94B-6bqhA:
37.5		 6a94B-6bqhA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A 134
SER A 138
VAL A 208
VAL A 215
ALA A 222
PHE A 327
ASN A 331
ASN A 351
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
None
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
 0.97A 6bqgA-6bqhA:
36.0		 6bqgA-6bqhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		9 / 12 ASP A 134
SER A 138
VAL A 208
VAL A 215
ALA A 222
PHE A 327
ASN A 331
GLU A 347
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
None
None
E2J  A1201 (-4.6A)
 1.12A 6bqgA-6bqhA:
36.0		 6bqgA-6bqhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 ASP A 134
SER A 138
VAL A 208
VAL A 215
GLY A 218
ALA A 222
ASN A 351
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 ( 3.8A)
E2J  A1201 (-3.8A)
 0.83A 6bqgA-6bqhA:
36.0		 6bqgA-6bqhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 ASP A 134
SER A 138
VAL A 208
VAL A 215
GLY A 218
ALA A 222
GLU A 347
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 ( 3.8A)
None
 1.03A 6bqgA-6bqhA:
36.0		 6bqgA-6bqhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 THR A 139
SER A 219
PHE A 320
TRP A 324
PHE A 328
 E2J  A1201 (-4.3A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
 0.95A 6cm4A-6bqhA:
30.7		 6cm4A-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 VAL A 135
THR A 139
PHE A 320
TRP A 324
PHE A 328
TYR A 358
 E2J  A1201 (-3.8A)
E2J  A1201 (-4.3A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
None
 0.40A 6cm4A-6bqhA:
30.7		 6cm4A-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 209
SER A 138
TRP A 324
VAL A 354
TYR A 358
 None
E2J  A1201 (-3.2A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
None
 1.48A 6drxA-6bqhA:
31.7		 6drxA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
SER A 138
THR A 139
TRP A 324
PHE A 327
VAL A 354
TYR A 358
 None
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.6A)
None
 0.74A 6drxA-6bqhA:
31.7		 6drxA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
SER A 138
TRP A 324
PHE A 327
ASN A 331
VAL A 354
TYR A 358
 None
E2J  A1201 (-3.2A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
None
E2J  A1201 (-4.6A)
None
 0.63A 6drxA-6bqhA:
31.7		 6drxA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
VAL A 135
SER A 138
THR A 139
ALA A 222
TRP A 324
TYR A 358
 None
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
E2J  A1201 ( 3.8A)
E2J  A1201 ( 3.7A)
None
 0.64A 6drxA-6bqhA:
31.7		 6drxA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
VAL A 135
SER A 138
THR A 139
TRP A 324
PHE A 327
TYR A 358
 None
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
None
 0.70A 6drxA-6bqhA:
31.7		 6drxA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		9 / 11 ASP A 134
VAL A 135
SER A 138
THR A 139
LEU A 209
ALA A 222
PHE A 327
VAL A 354
TYR A 358
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
None
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.6A)
None
 0.88A 6dryA-6bqhA:
31.5		 6dryA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 11 ASP A 134
VAL A 135
SER A 138
THR A 139
VAL A 208
LEU A 209
ALA A 222
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
None
None
E2J  A1201 ( 3.8A)
 0.87A 6dryA-6bqhA:
31.5		 6dryA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 SER A 138
PHE A 327
PHE A 328
ASN A 331
VAL A 354
TYR A 358
 E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
E2J  A1201 (-4.6A)
None
 0.62A 6drzA-6bqhA:
30.4		 6drzA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		8 / 12 VAL A 135
SER A 138
THR A 139
LEU A 209
PHE A 327
PHE A 328
VAL A 354
TYR A 358
 E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 (-4.6A)
None
 0.84A 6drzA-6bqhA:
30.4		 6drzA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
 1.32A 6h7jA-6bqhA:
26.5		 6h7jA-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.87A 6h7jA-6bqhA:
26.5		 6h7jA-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
VAL A 135
SER A 219
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.71A 6h7jA-6bqhA:
26.5		 6h7jA-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
 1.34A 6h7jB-6bqhA:
27.1		 6h7jB-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.88A 6h7jB-6bqhA:
27.1		 6h7jB-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
VAL A 135
SER A 219
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.70A 6h7jB-6bqhA:
27.1		 6h7jB-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
SER A 219
ASN A 331
TRP A 355
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
None
 0.86A 6h7lA-6bqhA:
26.7		 6h7lA-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
VAL A 135
TRP A 355
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
None
None
 0.59A 6h7lA-6bqhA:
26.7		 6h7lA-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
SER A 219
ASN A 331
TRP A 355
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
None
 0.87A 6h7lB-6bqhA:
27.1		 6h7lB-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
VAL A 135
TRP A 355
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
None
None
 0.59A 6h7lB-6bqhA:
27.1		 6h7lB-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
 1.34A 6h7mA-6bqhA:
26.8		 6h7mA-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.88A 6h7mA-6bqhA:
26.8		 6h7mA-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.56A 6h7mA-6bqhA:
26.8		 6h7mA-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		7 / 12 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.87A 6h7mB-6bqhA:
27.1		 6h7mB-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.56A 6h7mB-6bqhA:
27.1		 6h7mB-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
TRP A 324
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.56A 6iblA-6bqhA:
26.6		 6iblA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
VAL A 135
TRP A 324
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.8A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.63A 6iblA-6bqhA:
26.6		 6iblA-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
TRP A 324
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.59A 6iblB-6bqhA:
26.9		 6iblB-6bqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens) 		6 / 12 TRP A 130
VAL A 135
TRP A 324
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.8A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.61A 6iblB-6bqhA:
26.9		 6iblB-6bqhA:
undetectable