SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DYG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		4 / 6 TYR A  87
GLU A 147
ILE A 121
TYR A 119
 None
None
None
DYG  A  64 ( 4.8A)
 1.13A 1maaB-1xssA:
undetectable
1maaD-1xssA:
undetectable		 1maaB-1xssA:
18.16
1maaD-1xssA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		5 / 11 ILE A 198
ALA A 103
GLY A  16
PHE A  61
VAL A  60
 DYG  A  64 ( 3.7A)
None
None
None
None
 0.88A 2fxdA-1xssA:
undetectable		 2fxdA-1xssA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		5 / 12 GLU A 214
ARG A  66
MET A  14
GLY A  27
LEU A  42
 DYG  A  64 ( 3.7A)
DYG  A  64 ( 2.9A)
None
None
None
 1.08A 2jfaB-1xssA:
undetectable		 2jfaB-1xssA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		4 / 8 LYS A  69
HIS A 122
ARG A  95
ALA A  63
 DYG  A  66 ( 3.5A)
XYG  A  66 ( 3.8A)
XYG  A  66 ( 2.7A)
DYG  A  66 ( 3.8A)
 1.33A 2rk8A-2pxsA:
undetectable		 2rk8A-2pxsA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		3 / 3 HIS A 215
GLU A 214
HIS A 196
 None
DYG  A  64 ( 3.7A)
DYG  A  64 ( 3.5A)
 0.85A 3ba0A-1xssA:
undetectable		 3ba0A-1xssA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 HIS A 222
GLU A 221
HIS A 202
 None
DYG  A  66 ( 3.5A)
DYG  A  66 ( 3.2A)
 0.82A 3ba0A-2pxsA:
undetectable		 3ba0A-2pxsA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		4 / 8 ASN A 105
ILE A 107
PHE A  68
TYR A 119
 DYG  A  64 ( 4.1A)
None
None
DYG  A  64 ( 4.8A)
 1.12A 3ccfB-1xssA:
undetectable		 3ccfB-1xssA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		5 / 12 ALA A  63
ASP A 182
PHE A 181
GLY A 163
GLU A 150
 DYG  A  66 ( 3.8A)
None
None
None
DYG  A  66 ( 4.6A)
 1.29A 5hfjF-2pxsA:
undetectable		 5hfjF-2pxsA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		3 / 3 TYR A 119
TYR A  78
SER A  82
 DYG  A  64 ( 4.8A)
None
None
 0.99A 5iktB-1xssA:
undetectable		 5iktB-1xssA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1xss FLUORESCENT PROTEIN
(Favia
favus) 		5 / 12 VAL A 160
ASP A 159
GLU A 147
LEU A 164
SER A 145
 None
None
None
None
DYG  A  64 ( 2.5A)
 1.18A 5m5cB-1xssA:
undetectable		 5m5cB-1xssA:
18.71