SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DYA'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_A_CCSA381_0 (ESTROGEN RECEPTOR)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 5	HIS A 486 GLU A 489 ALA A 407 HIS A 397	DYA A 452 ( 3.9A) None None MGN A 402 ( 4.7A)	1.42A	1errA-5a8rA: undetectable 1errB-5a8rA: undetectable	1errA-5a8rA: 18.67 1errB-5a8rA: 18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_A_CHDA130_1 (FATTY ACID-BINDING PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	3 / 3	TYR A 490 ARG C 244 GLN A 453	None None DYA A 452 ( 4.6A)	0.91A	1tw4A-5a8rA: undetectable	1tw4A-5a8rA: 12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TEG_A_DAHA416_1 (PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	GLN A 433 PHE A 445 GLY A 400 ALA A 404 GLY A 485	DYA A 452 ( 3.9A) GL3 A 447 (-3.9A) MGN A 402 ( 4.2A) None None	1.17A	3tegA-5a8rA: 3.9	3tegA-5a8rA: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YMG_A_SAMA1001_0 (PUTATIVE SAM-DEPENDENT O-METHYLTRANFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	5 / 12	GLY B 354 TYR A 448 SER B 329 ALA B 389 ASN B 335	SMC A 454 ( 3.8A) DYA A 452 ( 4.5A) None None None	1.28A	4ymgA-5a8rB: undetectable	4ymgA-5a8rB: 20.54

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ERR_A_CCSA381_0","ESTROGEN RECEPTOR","5a8r","METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA","Methanothermobacter marburgensis",4,"HIS A 486;GLU A 489;ALA A 407;HIS A 397","DYA A 452 ( 3.9A);None;None;MGN A 402 ( 4.7A)","1.42A","1errA-5a8rA:undetectable;1errB-5a8rA:undetectable",null],["1TW4_A_CHDA130_1","FATTY ACID-BINDING PROTEIN","5a8r","METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA;METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA","Methanothermobacter marburgensis;Methanothermobacter marburgensis",3,"TYR A 490;ARG C 244;GLN A 453","None;None;DYA A 452 ( 4.6A)","0.91A","1tw4A-5a8rA:undetectable","1errA-5a8rA:18.67;1errB-5a8rA:18.67"],["3TEG_A_DAHA416_1","PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL","5a8r","METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA","Methanothermobacter marburgensis",5,"GLN A 433;PHE A 445;GLY A 400;ALA A 404;GLY A 485","DYA A 452 ( 3.9A);GL3 A 447 (-3.9A);MGN A 402 ( 4.2A);None;None","1.17A","3tegA-5a8rA:3.9","1tw4A-5a8rA:12.66"],["4YMG_A_SAMA1001_0","PUTATIVE SAM-DEPENDENT O-METHYLTRANFERASE","5a8r","METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA;METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA","Methanothermobacter marburgensis;Methanothermobacter marburgensis",5,"GLY B 354;TYR A 448;SER B 329;ALA B 389;ASN B 335","SMC A 454 ( 3.8A);DYA A 452 ( 4.5A);None;None;None","1.28A","4ymgA-5a8rB:undetectable","3tegA-5a8rA:20.18"]]