SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DXR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		6 / 11 LEU A  40
GLY A  41
GLY A  43
VAL A  48
ALA A  61
LEU A 164
 DXR  A 299 ( 4.3A)
DXR  A 299 ( 4.2A)
DXR  A 299 ( 4.1A)
DXR  A 299 (-4.3A)
DXR  A 299 ( 3.9A)
None
 0.83A 4ckiA-3ma6A:
22.1		 4ckiA-3ma6A:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		9 / 12 GLY A  41
VAL A  48
ALA A  61
MET A  95
LEU A  97
GLY A 117
LEU A 164
ILE A 177
LEU A 181
 DXR  A 299 ( 4.2A)
DXR  A 299 (-4.3A)
DXR  A 299 ( 3.9A)
DXR  A 299 (-3.2A)
None
None
None
DXR  A 299 ( 3.6A)
None
 0.41A 4ifgA-3ma6A:
31.1		 4ifgA-3ma6A:
90.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		7 / 12 MET A  95
LEU A  97
GLY A 117
GLU A 118
LEU A 164
ILE A 177
LEU A 181
 DXR  A 299 (-3.2A)
None
None
None
None
DXR  A 299 ( 3.6A)
None
 0.58A 4ifgA-3ma6A:
31.1		 4ifgA-3ma6A:
90.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		7 / 11 LEU A  40
GLY A  41
VAL A  48
ALA A  61
ASN A 162
LEU A 164
ASP A 178
 DXR  A 299 ( 4.3A)
DXR  A 299 ( 4.2A)
DXR  A 299 (-4.3A)
DXR  A 299 ( 3.9A)
None
None
None
 0.91A 4o0sA-3ma6A:
27.0		 4o0sA-3ma6A:
34.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 LEU A  40
VAL A  48
ILE A  94
ILE A 176
 DXR  A 299 ( 4.3A)
DXR  A 299 (-4.3A)
None
None
 0.60A 4tyjA-3ma6A:
21.0		 4tyjA-3ma6A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 ARG A  38
LEU A  40
ALA A  61
LEU A 164
 None
DXR  A 299 ( 4.3A)
DXR  A 299 ( 3.9A)
None
 0.86A 4wboC-3ma6A:
21.3		 4wboC-3ma6A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		5 / 12 VAL A 221
ILE A 177
ILE A  94
ASN A  93
HIS A 155
 None
DXR  A 299 ( 3.6A)
None
None
None
 1.30A 4xueA-3ma6A:
undetectable		 4xueA-3ma6A:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		6 / 11 LEU A  40
GLY A  41
VAL A  48
ALA A  61
GLU A 161
LEU A 164
 DXR  A 299 ( 4.3A)
DXR  A 299 ( 4.2A)
DXR  A 299 (-4.3A)
DXR  A 299 ( 3.9A)
None
None
 0.59A 5lvnA-3ma6A:
17.8		 5lvnA-3ma6A:
31.40