SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DXP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KT4_A_RTLA184_0 (PLASMA RETINOL-BINDING PROTEIN)	5z9y	THIAZOLE SYNTHASE (Mycobacterium tuberculosis)	5 / 12	LEU A 183 LEU A 206 ALA A 36 ALA A 220 MET A 223	None DXP A 301 (-4.7A) None None None	1.36A	1kt4A-5z9yA: undetectable	1kt4A-5z9yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOG_D_DHID8_0 (6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN)	5z9y	THIAZOLE SYNTHASE (Mycobacterium tuberculosis)	4 / 4	SER A 156 GLY A 155 GLY A 159 GLY A 188	None None DXP A 301 (-3.6A) None	0.88A	3bogB-5z9yA: undetectable 3bogD-5z9yA: undetectable	3bogB-5z9yA: undetectable 3bogD-5z9yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A84_A_DXCA1160_0 (MAJOR POLLEN ALLERGEN BET V 1-A)	5z9y	THIAZOLE SYNTHASE (Mycobacterium tuberculosis)	5 / 12	VAL A 227 ILE A 187 ILE A 158 MET A 19 LEU A 17	None None DXP A 301 (-4.1A) None None	1.15A	4a84A-5z9yA: undetectable	4a84A-5z9yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_B_SAMB601_0 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	3ll3	GLUCONATE KINASE (Lactobacillus acidophilus)	5 / 12	ASN A 377 ALA A 350 GLY A 340 GLY A 339 GLY A 488	None None DXP A3264 ( 4.5A) None None	1.01A	4obwB-3ll3A: undetectable	4obwB-3ll3A: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWA_A_GCSA301_1 (CHITOSANASE)	5z9y	THIAZOLE SYNTHASE (Mycobacterium tuberculosis)	4 / 8	ILE A 66 GLY A 20 THR A 43 LEU A 206	None DXP A 301 ( 3.8A) DXP A 301 (-3.3A) DXP A 301 (-4.7A)	1.04A	5hwaA-5z9yA: undetectable	5hwaA-5z9yA: 15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O4Y_D_CCSD14_0 (PHE-MAA-ASN-PRO-HIS- LEU-SER-TRP-SER-TRP- 9KK-9KK-ARG-CCS-GLY- NH2 PROGRAMMED CELL DEATH 1 LIGAND 1)	5z9y	THIAZOLE SYNTHASE (Mycobacterium tuberculosis)	5 / 12	LEU A 206 SER A 156 GLY A 163 GLY A 188 ARG A 212	DXP A 301 (-4.7A) None None None None	1.34A	5o4yD-5z9yA: undetectable 5o4yE-5z9yA: undetectable	5o4yD-5z9yA: undetectable 5o4yE-5z9yA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XPR_A_K86A1201_1 (ENDOTHELIN B RECEPTOR,ENDOLYSIN,E NDOTHELIN B RECEPTOR)	5z9y	THIAZOLE SYNTHASE (Mycobacterium tuberculosis)	5 / 12	VAL A 227 LEU A 206 LEU A 183 ILE A 164 ALA A 196	None DXP A 301 (-4.7A) None None None	1.40A	5xprA-5z9yA: undetectable	5xprA-5z9yA: 10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YBB_A_SAMA601_0 (TYPE I RESTRICTION-MODIFICA TION SYSTEM METHYLTRANSFERASE SUBUNIT)	5z9y	THIAZOLE SYNTHASE (Mycobacterium tuberculosis)	5 / 12	ALA A 207 GLY A 159 THR A 160 GLY A 186 LEU A 30	DXP A 301 (-3.6A) DXP A 301 (-3.6A) None DXP A 301 (-3.7A) None	1.17A	5ybbA-5z9yA: undetectable	5ybbA-5z9yA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KT4_A_RTLA184_0","PLASMA RETINOL-BINDING PROTEIN","5z9y","THIAZOLE SYNTHASE","Mycobacterium tuberculosis",5,"LEU A 183;LEU A 206;ALA A  36;ALA A 220;MET A 223","None;DXP A 301 (-4.7A);None;None;None","1.36A","1kt4A-5z9yA:undetectable",null],["3BOG_D_DHID8_0","6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN","5z9y","THIAZOLE SYNTHASE","Mycobacterium tuberculosis",4,"SER A 156;GLY A 155;GLY A 159;GLY A 188","None;None;DXP A 301 (-3.6A);None","0.88A","3bogB-5z9yA:undetectable;3bogD-5z9yA:undetectable","1kt4A-5z9yA:undetectable"],["4A84_A_DXCA1160_0","MAJOR POLLEN ALLERGEN BET V 1-A","5z9y","THIAZOLE SYNTHASE","Mycobacterium tuberculosis",5,"VAL A 227;ILE A 187;ILE A 158;MET A  19;LEU A  17","None;None;DXP A 301 (-4.1A);None;None","1.15A","4a84A-5z9yA:undetectable","3bogB-5z9yA:undetectable;3bogD-5z9yA:undetectable"],["4OBW_B_SAMB601_0","2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL","3ll3","GLUCONATE KINASE","Lactobacillus acidophilus",5,"ASN A 377;ALA A 350;GLY A 340;GLY A 339;GLY A 488","None;None;DXP A3264 ( 4.5A);None;None","1.01A","4obwB-3ll3A:undetectable","4a84A-5z9yA:undetectable"],["5HWA_A_GCSA301_1","CHITOSANASE","5z9y","THIAZOLE SYNTHASE","Mycobacterium tuberculosis",4,"ILE A  66;GLY A  20;THR A  43;LEU A 206","None;DXP A 301 ( 3.8A);DXP A 301 (-3.3A);DXP A 301 (-4.7A)","1.04A","5hwaA-5z9yA:undetectable","4obwB-3ll3A:19.05"],["5O4Y_D_CCSD14_0","PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2;PROGRAMMED CELL DEATH 1 LIGAND 1","5z9y","THIAZOLE SYNTHASE","Mycobacterium tuberculosis",5,"LEU A 206;SER A 156;GLY A 163;GLY A 188;ARG A 212","DXP A 301 (-4.7A);None;None;None;None","1.34A","5o4yD-5z9yA:undetectable;5o4yE-5z9yA:undetectable","5hwaA-5z9yA:15.50"],["5XPR_A_K86A1201_1","ENDOTHELIN B RECEPTOR,ENDOLYSIN,ENDOTHELIN B RECEPTOR","5z9y","THIAZOLE SYNTHASE","Mycobacterium tuberculosis",5,"VAL A 227;LEU A 206;LEU A 183;ILE A 164;ALA A 196","None;DXP A 301 (-4.7A);None;None;None","1.40A","5xprA-5z9yA:undetectable","5o4yD-5z9yA:undetectable;5o4yE-5z9yA:undetectable"],["5YBB_A_SAMA601_0","TYPE I RESTRICTION-MODIFICATION SYSTEM METHYLTRANSFERASE SUBUNIT","5z9y","THIAZOLE SYNTHASE","Mycobacterium tuberculosis",5,"ALA A 207;GLY A 159;THR A 160;GLY A 186;LEU A  30","DXP A 301 (-3.6A);DXP A 301 (-3.6A);None;DXP A 301 (-3.7A);None","1.17A","5ybbA-5z9yA:undetectable","5xprA-5z9yA:10.24"]]