SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DXJ'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AKD_A_CAMA420_0 (CYTOCHROME P450CAM)	6bld	CYTOCHROME P450 268A2 CYP268A2 (Mycobacterium marinum)	5 / 11	LEU A 256 VAL A 259 THR A 264 VAL A 308 VAL A 409	HEM A 501 ( 4.8A) DXJ A 502 (-4.5A) HEM A 501 (-3.4A) HEM A 501 ( 4.6A) None	0.85A	1akdA-6bldA: 41.2	1akdA-6bldA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DZ9_A_CAMA503_0 (CYTOCHROME P450-CAM)	6bld	CYTOCHROME P450 268A2 CYP268A2 (Mycobacterium marinum)	4 / 8	LEU A 256 VAL A 259 THR A 264 VAL A 308	HEM A 501 ( 4.8A) DXJ A 502 (-4.5A) HEM A 501 (-3.4A) HEM A 501 ( 4.6A)	0.53A	1dz9A-6bldA: 42.6	1dz9A-6bldA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PHG_A_MYTA422_1 (CYTOCHROME P450-CAM)	6bld	CYTOCHROME P450 268A2 CYP268A2 (Mycobacterium marinum)	5 / 11	LEU A 256 VAL A 259 GLY A 261 THR A 264 VAL A 308	HEM A 501 ( 4.8A) DXJ A 502 (-4.5A) HEM A 501 (-3.6A) HEM A 501 (-3.4A) HEM A 501 ( 4.6A)	1.08A	1phgA-6bldA: 42.3	1phgA-6bldA: 11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UYU_A_CAMA1416_0 (CYTOCHROME P450-CAM)	6bld	CYTOCHROME P450 268A2 CYP268A2 (Mycobacterium marinum)	4 / 8	LEU A 256 VAL A 259 THR A 264 VAL A 308	HEM A 501 ( 4.8A) DXJ A 502 (-4.5A) HEM A 501 (-3.4A) HEM A 501 ( 4.6A)	0.59A	1uyuA-6bldA: 42.3	1uyuA-6bldA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A1N_A_CAMA1422_0 (CYTOCHROME P450-CAM)	6bld	CYTOCHROME P450 268A2 CYP268A2 (Mycobacterium marinum)	5 / 11	LEU A 256 VAL A 259 GLY A 261 THR A 264 VAL A 308	HEM A 501 ( 4.8A) DXJ A 502 (-4.5A) HEM A 501 (-3.6A) HEM A 501 (-3.4A) HEM A 501 ( 4.6A)	1.19A	2a1nA-6bldA: 42.0	2a1nA-6bldA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A1N_A_CAMA1422_0 (CYTOCHROME P450-CAM)	6bld	CYTOCHROME P450 268A2 CYP268A2 (Mycobacterium marinum)	5 / 11	LEU A 256 VAL A 259 THR A 264 VAL A 308 VAL A 409	HEM A 501 ( 4.8A) DXJ A 502 (-4.5A) HEM A 501 (-3.4A) HEM A 501 ( 4.6A) None	0.80A	2a1nA-6bldA: 42.0	2a1nA-6bldA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z97_A_CAMA422_0 (CYTOCHROME P450-CAM)	6bld	CYTOCHROME P450 268A2 CYP268A2 (Mycobacterium marinum)	4 / 6	LEU A 256 VAL A 259 VAL A 308 VAL A 409	HEM A 501 ( 4.8A) DXJ A 502 (-4.5A) HEM A 501 ( 4.6A) None	0.78A	2z97A-6bldA: 42.4	2z97A-6bldA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZAX_A_CAMA422_0 (CYTOCHROME P450-CAM)	6bld	CYTOCHROME P450 268A2 CYP268A2 (Mycobacterium marinum)	4 / 7	LEU A 256 VAL A 259 THR A 264 VAL A 308	HEM A 501 ( 4.8A) DXJ A 502 (-4.5A) HEM A 501 (-3.4A) HEM A 501 ( 4.6A)	0.70A	2zaxA-6bldA: 42.0	2zaxA-6bldA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FWG_B_CAMB420_0 (CAMPHOR 5-MONOOXYGENASE)	6bld	CYTOCHROME P450 268A2 CYP268A2 (Mycobacterium marinum)	4 / 7	LEU A 256 VAL A 259 THR A 264 VAL A 308	HEM A 501 ( 4.8A) DXJ A 502 (-4.5A) HEM A 501 (-3.4A) HEM A 501 ( 4.6A)	0.68A	3fwgB-6bldA: 42.1	3fwgB-6bldA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FWI_A_CAMA420_0 (CAMPHOR 5-MONOOXYGENASE)	6bld	CYTOCHROME P450 268A2 CYP268A2 (Mycobacterium marinum)	4 / 7	LEU A 256 VAL A 259 THR A 264 VAL A 308	HEM A 501 ( 4.8A) DXJ A 502 (-4.5A) HEM A 501 (-3.4A) HEM A 501 ( 4.6A)	0.73A	3fwiA-6bldA: 41.7	3fwiA-6bldA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R9C_A_ECLA451_1 (CYTOCHROME P450 164A2)	6bld	CYTOCHROME P450 268A2 CYP268A2 (Mycobacterium marinum)	5 / 10	LEU A 187 LEU A 256 ALA A 260 THR A 264 VAL A 308	DXJ A 502 (-3.6A) HEM A 501 ( 4.8A) HEM A 501 ( 3.6A) HEM A 501 (-3.4A) HEM A 501 ( 4.6A)	0.77A	3r9cA-6bldA: 39.3	3r9cA-6bldA: 14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CP4_A_CAMA422_0 (CYTOCHROME P450CAM)	6bld	CYTOCHROME P450 268A2 CYP268A2 (Mycobacterium marinum)	5 / 9	LEU A 256 VAL A 259 THR A 264 VAL A 308 VAL A 409	HEM A 501 ( 4.8A) DXJ A 502 (-4.5A) HEM A 501 (-3.4A) HEM A 501 ( 4.6A) None	0.83A	5cp4A-6bldA: 42.4	5cp4A-6bldA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AKD_A_CAMA420_0","CYTOCHROME P450CAM","6bld","CYTOCHROME P450 268A2 CYP268A2","Mycobacterium marinum",5,"LEU A 256;VAL A 259;THR A 264;VAL A 308;VAL A 409","HEM A 501 ( 4.8A);DXJ A 502 (-4.5A);HEM A 501 (-3.4A);HEM A 501 ( 4.6A);None","0.85A","1akdA-6bldA:41.2",null],["1DZ9_A_CAMA503_0","CYTOCHROME P450-CAM","6bld","CYTOCHROME P450 268A2 CYP268A2","Mycobacterium marinum",4,"LEU A 256;VAL A 259;THR A 264;VAL A 308","HEM A 501 ( 4.8A);DXJ A 502 (-4.5A);HEM A 501 (-3.4A);HEM A 501 ( 4.6A)","0.53A","1dz9A-6bldA:42.6","1akdA-6bldA:undetectable"],["1PHG_A_MYTA422_1","CYTOCHROME P450-CAM","6bld","CYTOCHROME P450 268A2 CYP268A2","Mycobacterium marinum",5,"LEU A 256;VAL A 259;GLY A 261;THR A 264;VAL A 308","HEM A 501 ( 4.8A);DXJ A 502 (-4.5A);HEM A 501 (-3.6A);HEM A 501 (-3.4A);HEM A 501 ( 4.6A)","1.08A","1phgA-6bldA:42.3","1dz9A-6bldA:undetectable"],["1UYU_A_CAMA1416_0","CYTOCHROME P450-CAM","6bld","CYTOCHROME P450 268A2 CYP268A2","Mycobacterium marinum",4,"LEU A 256;VAL A 259;THR A 264;VAL A 308","HEM A 501 ( 4.8A);DXJ A 502 (-4.5A);HEM A 501 (-3.4A);HEM A 501 ( 4.6A)","0.59A","1uyuA-6bldA:42.3","1phgA-6bldA:11.55"],["2A1N_A_CAMA1422_0","CYTOCHROME P450-CAM","6bld","CYTOCHROME P450 268A2 CYP268A2","Mycobacterium marinum",5,"LEU A 256;VAL A 259;GLY A 261;THR A 264;VAL A 308","HEM A 501 ( 4.8A);DXJ A 502 (-4.5A);HEM A 501 (-3.6A);HEM A 501 (-3.4A);HEM A 501 ( 4.6A)","1.19A","2a1nA-6bldA:42.0","1uyuA-6bldA:undetectable"],["2A1N_A_CAMA1422_0","CYTOCHROME P450-CAM","6bld","CYTOCHROME P450 268A2 CYP268A2","Mycobacterium marinum",5,"LEU A 256;VAL A 259;THR A 264;VAL A 308;VAL A 409","HEM A 501 ( 4.8A);DXJ A 502 (-4.5A);HEM A 501 (-3.4A);HEM A 501 ( 4.6A);None","0.80A","2a1nA-6bldA:42.0","2a1nA-6bldA:undetectable"],["2Z97_A_CAMA422_0","CYTOCHROME P450-CAM","6bld","CYTOCHROME P450 268A2 CYP268A2","Mycobacterium marinum",4,"LEU A 256;VAL A 259;VAL A 308;VAL A 409","HEM A 501 ( 4.8A);DXJ A 502 (-4.5A);HEM A 501 ( 4.6A);None","0.78A","2z97A-6bldA:42.4","2a1nA-6bldA:undetectable"],["2ZAX_A_CAMA422_0","CYTOCHROME P450-CAM","6bld","CYTOCHROME P450 268A2 CYP268A2","Mycobacterium marinum",4,"LEU A 256;VAL A 259;THR A 264;VAL A 308","HEM A 501 ( 4.8A);DXJ A 502 (-4.5A);HEM A 501 (-3.4A);HEM A 501 ( 4.6A)","0.70A","2zaxA-6bldA:42.0","2z97A-6bldA:undetectable"],["3FWG_B_CAMB420_0","CAMPHOR 5-MONOOXYGENASE","6bld","CYTOCHROME P450 268A2 CYP268A2","Mycobacterium marinum",4,"LEU A 256;VAL A 259;THR A 264;VAL A 308","HEM A 501 ( 4.8A);DXJ A 502 (-4.5A);HEM A 501 (-3.4A);HEM A 501 ( 4.6A)","0.68A","3fwgB-6bldA:42.1","2zaxA-6bldA:undetectable"],["3FWI_A_CAMA420_0","CAMPHOR 5-MONOOXYGENASE","6bld","CYTOCHROME P450 268A2 CYP268A2","Mycobacterium marinum",4,"LEU A 256;VAL A 259;THR A 264;VAL A 308","HEM A 501 ( 4.8A);DXJ A 502 (-4.5A);HEM A 501 (-3.4A);HEM A 501 ( 4.6A)","0.73A","3fwiA-6bldA:41.7","3fwgB-6bldA:undetectable"],["3R9C_A_ECLA451_1","CYTOCHROME P450 164A2","6bld","CYTOCHROME P450 268A2 CYP268A2","Mycobacterium marinum",5,"LEU A 187;LEU A 256;ALA A 260;THR A 264;VAL A 308","DXJ A 502 (-3.6A);HEM A 501 ( 4.8A);HEM A 501 ( 3.6A);HEM A 501 (-3.4A);HEM A 501 ( 4.6A)","0.77A","3r9cA-6bldA:39.3","3fwiA-6bldA:undetectable"],["5CP4_A_CAMA422_0","CYTOCHROME P450CAM","6bld","CYTOCHROME P450 268A2 CYP268A2","Mycobacterium marinum",5,"LEU A 256;VAL A 259;THR A 264;VAL A 308;VAL A 409","HEM A 501 ( 4.8A);DXJ A 502 (-4.5A);HEM A 501 (-3.4A);HEM A 501 ( 4.6A);None","0.83A","5cp4A-6bldA:42.4","3r9cA-6bldA:14.41"]]