SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DX5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		4 / 5 VAL A 196
SER A   9
ASP A  86
GLN A 134
 None
DX5  A1901 (-2.7A)
None
None
 1.21A 1n2xB-2fliA:
undetectable		 1n2xB-2fliA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 8 ALA A   7
ASP A  65
ILE A  25
ILE A  10
GLY A 198
 None
None
None
None
DX5  A1901 (-3.4A)
 1.26A 1sh9A-2fliA:
undetectable		 1sh9A-2fliA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 12 ASP A 176
THR A 213
PRO A   8
GLY A 198
LEU A 201
 DX5  A1901 ( 2.6A)
None
None
DX5  A1901 (-3.4A)
None
 1.06A 3j6pB-2fliA:
3.1		 3j6pB-2fliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 10 PHE A  42
GLY A 143
VAL A  71
ASN A  45
GLY A  40
 None
DX5  A1901 (-3.6A)
None
None
None
 1.26A 3km6A-2fliA:
undetectable		 3km6A-2fliA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 9 PHE A  42
GLY A 143
VAL A  71
ASN A  45
GLY A  40
 None
DX5  A1901 (-3.6A)
None
None
None
 1.27A 3kmoA-2fliA:
undetectable		 3kmoA-2fliA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		3 / 3 HIS A  67
HIS A  91
MET A  69
 ZN  A1981 ( 3.3A)
None
DX5  A1901 (-3.4A)
 0.64A 3mihA-2fliA:
undetectable		 3mihA-2fliA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 12 ASP A 176
THR A 213
PRO A   8
GLY A 198
LEU A 201
 DX5  A1901 ( 2.6A)
None
None
DX5  A1901 (-3.4A)
None
 0.97A 5ogcB-2fliA:
3.1		 5ogcB-2fliA:
20.18