SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DVA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 5 PHE A 318
PHE A 315
PHE A 209
VAL A 304
 None
DVA  A 602 (-3.7A)
DVA  A 602 ( 4.2A)
None
 1.22A 2lh6A-3vnsA:
undetectable		 2lh6A-3vnsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 10 PHE A 191
GLY A 216
PHE A 209
PHE A 315
PHE A 318
 None
None
DVA  A 602 ( 4.2A)
DVA  A 602 (-3.7A)
None
 1.39A 3r6wA-3vnsA:
undetectable
3r6wB-3vnsA:
2.1		 3r6wA-3vnsA:
19.19
3r6wB-3vnsA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 7 PHE A 207
ASP A 208
GLY A 280
THR A 310
 DVA  A 602 (-4.1A)
DVA  A 602 (-2.8A)
DVA  A 602 ( 4.1A)
AMP  A 601 (-3.9A)
 0.83A 3vnsA-3vnsA:
74.1		 3vnsA-3vnsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		7 / 7 PHE A 207
ASP A 208
PHE A 209
GLY A 281
THR A 310
PHE A 315
LYS A 507
 DVA  A 602 (-4.1A)
DVA  A 602 (-2.8A)
DVA  A 602 ( 4.2A)
AMP  A 601 ( 3.4A)
AMP  A 601 (-3.9A)
DVA  A 602 (-3.7A)
DVA  A 602 ( 2.7A)
 0.00A 3vnsA-3vnsA:
74.1		 3vnsA-3vnsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 8 ARG A 290
ALA A 286
LEU A 289
PHE A 207
 None
None
None
DVA  A 602 (-4.1A)
 1.02A 4rkuA-3vnsA:
undetectable
4rkuJ-3vnsA:
undetectable		 4rkuA-3vnsA:
23.35
4rkuJ-3vnsA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 7 PHE A 207
ASP A 208
GLY A 280
THR A 310
 DVA  A 602 (-4.1A)
DVA  A 602 (-2.8A)
DVA  A 602 ( 4.1A)
AMP  A 601 (-3.9A)
 1.05A 4zxiA-3vnsA:
46.1		 4zxiA-3vnsA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 7 PHE A 207
ASP A 208
GLY A 281
THR A 310
LYS A 507
 DVA  A 602 (-4.1A)
DVA  A 602 (-2.8A)
AMP  A 601 ( 3.4A)
AMP  A 601 (-3.9A)
DVA  A 602 ( 2.7A)
 0.56A 4zxiA-3vnsA:
46.1		 4zxiA-3vnsA:
17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		6 / 7 PHE A 207
ASP A 208
PHE A 209
GLY A 281
GLY A 308
LYS A 507
 DVA  A 602 (-4.1A)
DVA  A 602 (-2.8A)
DVA  A 602 ( 4.2A)
AMP  A 601 ( 3.4A)
DVA  A 602 ( 4.2A)
DVA  A 602 ( 2.7A)
 0.47A 5n9xA-3vnsA:
59.3		 5n9xA-3vnsA:
56.47