SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DUR'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZ1_B_SHHB2552_1 (HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE)	2i7d	5'(3')-DEOXYRIBONUCL EOTIDASE, CYTOSOLIC TYPE (Homo sapiens)	5 / 12	LEU A 102 HIS A 167 ASP A 145 PHE A 18 PHE A 71	DUR A 300 (-4.7A) None MG A 728 (-2.6A) DUR A 300 (-3.6A) None	1.17A	1zz1B-2i7dA: undetectable 1zz1C-2i7dA: undetectable	1zz1B-2i7dA: 20.42 1zz1C-2i7dA: 20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_A_SAMA1001_1 (SAM DEPENDENT METHYLTRANSFERASE)	2i7d	5'(3')-DEOXYRIBONUCL EOTIDASE, CYTOSOLIC TYPE (Homo sapiens)	3 / 3	ASP A 144 ASP A 147 ASP A 12	ALF A 400 ( 4.2A) None DUR A 300 (-3.7A)	0.55A	2igtA-2i7dA: 2.3	2igtA-2i7dA: 22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_B_SAMB1002_1 (SAM DEPENDENT METHYLTRANSFERASE)	2i7d	5'(3')-DEOXYRIBONUCL EOTIDASE, CYTOSOLIC TYPE (Homo sapiens)	3 / 3	ASP A 144 ASP A 147 ASP A 12	ALF A 400 ( 4.2A) None DUR A 300 (-3.7A)	0.54A	2igtB-2i7dA: 2.4	2igtB-2i7dA: 22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AF3_A_PAUA314_0 (PANTOTHENATE KINASE)	5y5p	WSV112 (White spot syndrome virus)	4 / 6	TYR A 91 ARG A 92 MET A 10 PHE A 12	DUR A 501 (-3.3A) None None None	1.42A	3af3A-5y5pA: undetectable	3af3A-5y5pA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J7X_A_SASA806_1 (SEPIAPTERIN REDUCTASE)	2i7d	5'(3')-DEOXYRIBONUCL EOTIDASE, CYTOSOLIC TYPE (Homo sapiens)	5 / 12	LEU A 102 CYH A 108 PHE A 71 ASP A 17 GLY A 13	DUR A 300 (-4.7A) None None None MG A 728 ( 4.5A)	1.16A	4j7xA-2i7dA: undetectable	4j7xA-2i7dA: 22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J7X_F_SASF805_1 (SEPIAPTERIN REDUCTASE)	2i7d	5'(3')-DEOXYRIBONUCL EOTIDASE, CYTOSOLIC TYPE (Homo sapiens)	5 / 12	LEU A 102 CYH A 108 PHE A 71 ASP A 17 GLY A 13	DUR A 300 (-4.7A) None None None MG A 728 ( 4.5A)	1.19A	4j7xF-2i7dA: 3.5	4j7xF-2i7dA: 22.49

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ZZ1_B_SHHB2552_1","HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE;HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE","2i7d","5'(3')-DEOXYRIBONUCLEOTIDASE, CYTOSOLIC TYPE","Homo sapiens",5,"LEU A 102;HIS A 167;ASP A 145;PHE A  18;PHE A  71","DUR A 300 (-4.7A);None; MG A 728 (-2.6A);DUR A 300 (-3.6A);None","1.17A","1zz1B-2i7dA:undetectable;1zz1C-2i7dA:undetectable",null],["2IGT_A_SAMA1001_1","SAM DEPENDENT METHYLTRANSFERASE","2i7d","5'(3')-DEOXYRIBONUCLEOTIDASE, CYTOSOLIC TYPE","Homo sapiens",3,"ASP A 144;ASP A 147;ASP A  12","ALF A 400 ( 4.2A);None;DUR A 300 (-3.7A)","0.55A","2igtA-2i7dA:2.3","1zz1B-2i7dA:20.42;1zz1C-2i7dA:20.42"],["2IGT_B_SAMB1002_1","SAM DEPENDENT METHYLTRANSFERASE","2i7d","5'(3')-DEOXYRIBONUCLEOTIDASE, CYTOSOLIC TYPE","Homo sapiens",3,"ASP A 144;ASP A 147;ASP A  12","ALF A 400 ( 4.2A);None;DUR A 300 (-3.7A)","0.54A","2igtB-2i7dA:2.4","2igtA-2i7dA:22.62"],["3AF3_A_PAUA314_0","PANTOTHENATE KINASE","5y5p","WSV112","White spot syndrome virus",4,"TYR A  91;ARG A  92;MET A  10;PHE A  12","DUR A 501 (-3.3A);None;None;None","1.42A","3af3A-5y5pA:undetectable","2igtB-2i7dA:22.62"],["4J7X_A_SASA806_1","SEPIAPTERIN REDUCTASE","2i7d","5'(3')-DEOXYRIBONUCLEOTIDASE, CYTOSOLIC TYPE","Homo sapiens",5,"LEU A 102;CYH A 108;PHE A  71;ASP A  17;GLY A  13","DUR A 300 (-4.7A);None;None;None; MG A 728 ( 4.5A)","1.16A","4j7xA-2i7dA:undetectable","3af3A-5y5pA:undetectable"],["4J7X_F_SASF805_1","SEPIAPTERIN REDUCTASE","2i7d","5'(3')-DEOXYRIBONUCLEOTIDASE, CYTOSOLIC TYPE","Homo sapiens",5,"LEU A 102;CYH A 108;PHE A  71;ASP A  17;GLY A  13","DUR A 300 (-4.7A);None;None;None; MG A 728 ( 4.5A)","1.19A","4j7xF-2i7dA:3.5","4j7xA-2i7dA:22.49"]]