SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DUC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1uaq CYTOSINE DEAMINASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  88
ILE A  33
GLY A  34
GLY A  35
SER A 116
 None
DUC  A 300 (-3.4A)
None
None
None
 1.12A 2qmmA-1uaqA:
undetectable		 2qmmA-1uaqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 1uaq CYTOSINE DEAMINASE
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  51
GLY A  35
SER A  66
GLY A  25
LEU A  37
 DUC  A 300 (-3.9A)
None
None
None
None
 1.17A 3r24A-1uaqA:
undetectable		 3r24A-1uaqA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1uaq CYTOSINE DEAMINASE
(Saccharomyces
cerevisiae) 		4 / 4 GLY A  63
GLY A  34
THR A  86
LEU A  84
 DUC  A 300 (-3.9A)
None
None
None
 0.84A 3si7C-1uaqA:
undetectable
3si7D-1uaqA:
undetectable		 3si7C-1uaqA:
20.36
3si7D-1uaqA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1uaq CYTOSINE DEAMINASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 116
SER A  89
PHE A 114
ASP A 155
ILE A  33
 None
None
DUC  A 300 ( 4.8A)
DUC  A 300 (-3.3A)
DUC  A 300 (-3.4A)
 1.44A 4ktvA-1uaqA:
0.0
4ktvB-1uaqA:
0.0		 4ktvA-1uaqA:
17.63
4ktvB-1uaqA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1uaq CYTOSINE DEAMINASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  49
GLY A  34
ILE A  17
ASN A  51
LEU A  68
 None
None
None
DUC  A 300 (-3.9A)
None
 0.98A 5fa8A-1uaqA:
undetectable		 5fa8A-1uaqA:
22.35