SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DU1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 HIS A 251
ASN A 184
THR A  91
VAL A  87
ILE A 175
 None
None
DU1  A1201 (-3.7A)
DU1  A1201 (-4.7A)
None
 1.42A 2o7oA-5uenA:
0.0		 2o7oA-5uenA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		8 / 12 LEU A  88
PHE A 171
MET A 180
TRP A 247
LEU A 250
ASN A 254
ILE A 274
HIS A 278
 None
DU1  A1201 (-3.5A)
DU1  A1201 (-3.4A)
None
DU1  A1201 (-4.4A)
DU1  A1201 (-3.1A)
DU1  A1201 (-4.3A)
None
 0.78A 2ydoA-5uenA:
30.7		 2ydoA-5uenA:
41.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		8 / 12 LEU A  88
THR A  91
PHE A 171
MET A 180
TRP A 247
LEU A 250
ASN A 254
ILE A 274
 None
DU1  A1201 (-3.7A)
DU1  A1201 (-3.5A)
DU1  A1201 (-3.4A)
None
DU1  A1201 (-4.4A)
DU1  A1201 (-3.1A)
DU1  A1201 (-4.3A)
 1.07A 2ydoA-5uenA:
30.7		 2ydoA-5uenA:
41.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		6 / 7 VAL A  87
PHE A 171
MET A 180
LEU A 250
ASN A 254
ILE A 274
 DU1  A1201 (-4.7A)
DU1  A1201 (-3.5A)
DU1  A1201 (-3.4A)
DU1  A1201 (-4.4A)
DU1  A1201 (-3.1A)
DU1  A1201 (-4.3A)
 0.94A 3rfmA-5uenA:
34.5		 3rfmA-5uenA:
40.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		6 / 8 LEU A  88
PHE A 171
MET A 180
LEU A 250
ASN A 254
ILE A 274
 None
DU1  A1201 (-3.5A)
DU1  A1201 (-3.4A)
DU1  A1201 (-4.4A)
DU1  A1201 (-3.1A)
DU1  A1201 (-4.3A)
 0.74A 5mzjA-5uenA:
36.2		 5mzjA-5uenA:
64.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		6 / 9 VAL A  87
PHE A 171
MET A 180
LEU A 250
ASN A 254
ILE A 274
 DU1  A1201 (-4.7A)
DU1  A1201 (-3.5A)
DU1  A1201 (-3.4A)
DU1  A1201 (-4.4A)
DU1  A1201 (-3.1A)
DU1  A1201 (-4.3A)
 0.58A 5mzpA-5uenA:
41.8		 5mzpA-5uenA:
64.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		5 / 10 VAL A  62
LEU A 250
ILE A 274
THR A 277
HIS A 278
 None
DU1  A1201 (-4.4A)
DU1  A1201 (-4.3A)
None
None
 1.23A 6d9hR-5uenA:
32.0		 6d9hR-5uenA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		7 / 10 VAL A  87
PHE A 171
GLU A 172
MET A 180
LEU A 250
ASN A 254
HIS A 278
 DU1  A1201 (-4.7A)
DU1  A1201 (-3.5A)
DU1  A1201 (-3.6A)
DU1  A1201 (-3.4A)
DU1  A1201 (-4.4A)
DU1  A1201 (-3.1A)
None
 1.13A 6d9hR-5uenA:
32.0		 6d9hR-5uenA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		8 / 10 VAL A  87
PHE A 171
MET A 180
LEU A 250
ASN A 254
ILE A 274
THR A 277
HIS A 278
 DU1  A1201 (-4.7A)
DU1  A1201 (-3.5A)
DU1  A1201 (-3.4A)
DU1  A1201 (-4.4A)
DU1  A1201 (-3.1A)
DU1  A1201 (-4.3A)
None
None
 1.03A 6d9hR-5uenA:
32.0		 6d9hR-5uenA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		7 / 10 VAL A  87
THR A  91
PHE A 171
GLU A 172
MET A 180
LEU A 250
ASN A 254
 DU1  A1201 (-4.7A)
DU1  A1201 (-3.7A)
DU1  A1201 (-3.5A)
DU1  A1201 (-3.6A)
DU1  A1201 (-3.4A)
DU1  A1201 (-4.4A)
DU1  A1201 (-3.1A)
 1.09A 6d9hR-5uenA:
32.0		 6d9hR-5uenA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		8 / 10 VAL A  87
THR A  91
PHE A 171
MET A 180
LEU A 250
ASN A 254
ILE A 274
THR A 277
 DU1  A1201 (-4.7A)
DU1  A1201 (-3.7A)
DU1  A1201 (-3.5A)
DU1  A1201 (-3.4A)
DU1  A1201 (-4.4A)
DU1  A1201 (-3.1A)
DU1  A1201 (-4.3A)
None
 1.07A 6d9hR-5uenA:
32.0		 6d9hR-5uenA:
12.64