SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DTV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 135
GLU A 186
TYR A 134
ALA A 193
GLY A 192
 None
None
DTV  A 402 ( 4.4A)
None
None
 1.39A 1l5rA-3k2gA:
2.4		 1l5rA-3k2gA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 151
GLY A 177
SER A 179
TRP A  42
SER A 138
 None
None
None
DTV  A 402 (-3.7A)
None
 1.29A 1nbhA-3k2gA:
undetectable		 1nbhA-3k2gA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 151
GLY A 177
SER A 179
TRP A  42
SER A 138
 None
None
None
DTV  A 402 (-3.7A)
None
 1.29A 1nbhC-3k2gA:
undetectable		 1nbhC-3k2gA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 151
GLY A 177
SER A 179
TRP A  42
SER A 138
 None
None
None
DTV  A 402 (-3.7A)
None
 1.29A 1nbhD-3k2gA:
undetectable		 1nbhD-3k2gA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 177
SER A 179
TRP A  42
GLY A 108
SER A 138
 None
None
DTV  A 402 (-3.7A)
None
None
 1.27A 1nbiC-3k2gA:
undetectable		 1nbiC-3k2gA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 177
SER A 179
TRP A  42
GLY A 108
SER A 138
 None
None
DTV  A 402 (-3.7A)
None
None
 1.28A 1nbiD-3k2gA:
undetectable		 1nbiD-3k2gA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5c17 MERB2
(Bacillus
megaterium) 		5 / 12 ILE A 130
ILE A 104
THR A 106
VAL A 152
HIS A 169
 None
DTV  A 303 ( 3.0A)
None
None
GOL  A 302 (-3.0A)
 1.12A 2qo5A-5c17A:
undetectable		 2qo5A-5c17A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5c17 MERB2
(Bacillus
megaterium) 		4 / 5 ARG A  65
PHE A 154
PHE A  10
LEU A  14
 None
DTV  A 303 (-3.0A)
DTV  A 303 ( 3.8A)
None
 1.33A 2y69C-5c17A:
undetectable
2y69J-5c17A:
undetectable		 2y69C-5c17A:
21.82
2y69J-5c17A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5c17 MERB2
(Bacillus
megaterium) 		4 / 5 ARG A  65
PHE A 154
PHE A  10
LEU A  14
 None
DTV  A 303 (-3.0A)
DTV  A 303 ( 3.8A)
None
 1.35A 2y69P-5c17A:
undetectable
2y69W-5c17A:
undetectable		 2y69P-5c17A:
21.82
2y69W-5c17A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5c17 MERB2
(Bacillus
megaterium) 		4 / 5 ARG A  65
PHE A 154
PHE A  10
LEU A  14
 None
DTV  A 303 (-3.0A)
DTV  A 303 ( 3.8A)
None
 1.31A 3abmC-5c17A:
undetectable
3abmJ-5c17A:
undetectable		 3abmC-5c17A:
21.82
3abmJ-5c17A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ASN A  77
ASP A 270
GLN A 271
 None
None
DTV  A 402 ( 4.0A)
 0.72A 3eeyC-3k2gA:
undetectable		 3eeyC-3k2gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ASN A  77
ASP A 270
GLN A 271
 None
None
DTV  A 402 ( 4.0A)
 0.74A 3eeyD-3k2gA:
undetectable		 3eeyD-3k2gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ASN A  77
ASP A 270
GLN A 271
 None
None
DTV  A 402 ( 4.0A)
 0.72A 3eeyE-3k2gA:
undetectable		 3eeyE-3k2gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5c17 MERB2
(Bacillus
megaterium) 		5 / 10 ILE A  29
ALA A  79
TYR A  11
LEU A 204
ILE A 168
 None
None
None
None
DTV  A 303 ( 4.9A)
 1.24A 3prsA-5c17A:
undetectable		 3prsA-5c17A:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RHG_A_BEZA369_0
(PUTATIVE
PHOPHOTRIESTERASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		6 / 10 HIS A 207
TRP A 211
HIS A 236
MET A 261
ASP A 302
PHE A 304
 ZN  A 401 (-3.4A)
None
ZN  A 401 (-3.5A)
None
ZN  A 400 (-2.6A)
DTV  A 402 (-4.2A)
 0.17A 3rhgA-3k2gA:
51.5		 3rhgA-3k2gA:
39.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 HIS A  32
HIS A  34
TYR A 134
GLU A 175
 ZN  A 400 (-3.3A)
ZN  A 400 (-3.3A)
DTV  A 402 ( 4.4A)
ZN  A 401 ( 2.6A)
 1.08A 4pahA-3k2gA:
undetectable		 4pahA-3k2gA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ALA A  68
LEU A  96
ASP A 102
ASN A 100
TYR A  33
 None
None
DTV  A1405 ( 2.9A)
None
None
 0.84A 4pclA-1nytA:
5.6		 4pclA-1nytA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ASN A  86
LEU A  47
PHE A  69
 DTV  A1405 (-4.0A)
None
None
 0.81A 5dsgA-1nytA:
undetectable		 5dsgA-1nytA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 1nyt SHIKIMATE
5-DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ARG A  78
GLY A  98
THR A  76
ASN A  86
 None
None
None
DTV  A1405 (-4.0A)
 1.06A 5hwaA-1nytA:
undetectable		 5hwaA-1nytA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 4 HIS A  32
HIS A  34
TYR A 134
GLU A 175
 ZN  A 400 (-3.3A)
ZN  A 400 (-3.3A)
DTV  A 402 ( 4.4A)
ZN  A 401 ( 2.6A)
 1.07A 5pahA-3k2gA:
undetectable		 5pahA-3k2gA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 HIS A  32
HIS A  34
TYR A 134
GLU A 175
 ZN  A 400 (-3.3A)
ZN  A 400 (-3.3A)
DTV  A 402 ( 4.4A)
ZN  A 401 ( 2.6A)
 1.09A 6pahA-3k2gA:
undetectable		 6pahA-3k2gA:
21.95