SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DTB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		6 / 12 TYR A  59
PRO A  61
ARG A 168
LEU A 224
VAL A 225
LEU A 291
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SF4  A 401 ( 4.4A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
DTB  A 502 ( 3.3A)
 1.18A 1r30A-1r30A:
58.6		 1r30A-1r30A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		12 / 12 TYR A  59
PRO A  61
THR A 130
GLY A 132
ASN A 151
ASN A 153
ASP A 155
ARG A 173
ILE A 192
LEU A 224
VAL A 225
LEU A 291
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 ( 4.0A)
SAM  A 501 (-2.7A)
DTB  A 502 (-3.9A)
DTB  A 502 ( 3.7A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
DTB  A 502 ( 3.3A)
 0.05A 1r30A-1r30A:
58.6		 1r30A-1r30A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		6 / 12 TYR A  59
PRO A  61
ARG A 168
LEU A 224
VAL A 225
LEU A 291
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SF4  A 401 ( 4.4A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
DTB  A 502 ( 3.3A)
 1.18A 1r30B-1r30A:
57.5		 1r30B-1r30A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		12 / 12 TYR A  59
PRO A  61
THR A 130
GLY A 132
ASN A 151
HIS A 152
ASN A 153
ARG A 173
ILE A 192
LEU A 224
VAL A 225
LEU A 291
 SAM  A 501 (-4.4A)
SAM  A 501 (-4.5A)
SAM  A 501 ( 4.0A)
SAM  A 501 (-2.7A)
DTB  A 502 (-3.9A)
SAM  A 501 ( 4.9A)
DTB  A 502 ( 3.7A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.4A)
DTB  A 502 ( 3.3A)
 0.05A 1r30B-1r30A:
57.5		 1r30B-1r30A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 4dne STREPTAVIDIN
(Streptomyces
avidinii) 		4 / 7 TRP A  75
GLY A  94
THR A 106
TRP A 108
 None
None
None
DTB  A 201 (-3.3A)
 1.26A 2o5yH-4dneA:
undetectable
2o5yL-4dneA:
undetectable		 2o5yH-4dneA:
23.87
2o5yL-4dneA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4dne STREPTAVIDIN
(Streptomyces
avidinii) 		6 / 7 ASN A  23
LEU A  25
SER A  27
TYR A  43
THR A  45
TRP A  92
 DTB  A 201 (-3.4A)
DTB  A 201 ( 4.7A)
DTB  A 201 (-2.6A)
DTB  A 201 (-4.7A)
DTB  A 201 (-3.7A)
DTB  A 201 ( 4.5A)
 0.35A 2uz2A-4dneA:
16.6		 2uz2A-4dneA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 5 LEU A 291
ALA A 263
PHE A 285
ASN A 153
 DTB  A 502 ( 3.3A)
DTB  A 502 (-3.4A)
DTB  A 502 (-4.5A)
DTB  A 502 ( 3.7A)
 1.40A 3uq6A-1r30A:
2.2		 3uq6A-1r30A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 4 LEU A 291
ALA A 263
PHE A 285
ASN A 153
 DTB  A 502 ( 3.3A)
DTB  A 502 (-3.4A)
DTB  A 502 (-4.5A)
DTB  A 502 ( 3.7A)
 1.45A 3vaqA-1r30A:
2.5		 3vaqA-1r30A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		4 / 8 ALA A 210
VAL A 219
PRO A 220
VAL A 187
 None
None
DTB  A 502 ( 4.7A)
None
 0.53A 4jltA-1r30A:
0.0		 4jltA-1r30A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		3 / 3 LEU A 206
LEU A 174
ASN A 153
 None
None
DTB  A 502 ( 3.7A)
 0.72A 4otwA-1r30A:
undetectable		 4otwA-1r30A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1r30 BIOTIN SYNTHASE
(Escherichia
coli) 		3 / 3 ARG A 260
PRO A 220
ASN A 153
 FES  A 402 (-2.5A)
DTB  A 502 ( 4.7A)
DTB  A 502 ( 3.7A)
 0.98A 5jwaA-1r30A:
undetectable
5jwaH-1r30A:
undetectable		 5jwaA-1r30A:
20.42
5jwaH-1r30A:
20.42