SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DST'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3n0g ISOPRENE SYNTHASE
(Populus
tremula
x
Populus
alba) 		3 / 3 GLU A 423
ASN A 441
TRP A 426
 DST  A 601 ( 3.3A)
None
None
 1.15A 1r15C-3n0gA:
undetectable		 1r15C-3n0gA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3n0g ISOPRENE SYNTHASE
(Populus
tremula
x
Populus
alba) 		3 / 3 GLU A 423
ASN A 441
TRP A 426
 DST  A 601 ( 3.3A)
None
None
 1.12A 1r15D-3n0gA:
undetectable		 1r15D-3n0gA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3n0g ISOPRENE SYNTHASE
(Populus
tremula
x
Populus
alba) 		3 / 3 GLU A 423
ASN A 441
TRP A 426
 DST  A 601 ( 3.3A)
None
None
 1.15A 1r15E-3n0gA:
undetectable		 1r15E-3n0gA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 3n0g ISOPRENE SYNTHASE
(Populus
tremula
x
Populus
alba) 		3 / 3 GLU A 423
ASN A 441
TRP A 426
 DST  A 601 ( 3.3A)
None
None
 1.13A 1r15F-3n0gA:
undetectable		 1r15F-3n0gA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3n0g ISOPRENE SYNTHASE
(Populus
tremula
x
Populus
alba) 		5 / 11 ILE A 393
LEU A 386
ILE A 390
SER A 447
PHE A 454
 None
None
None
DST  A 601 ( 4.4A)
None
 0.97A 2w9sA-3n0gA:
undetectable		 2w9sA-3n0gA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3n0g ISOPRENE SYNTHASE
(Populus
tremula
x
Populus
alba) 		5 / 11 ILE A 393
LEU A 386
ILE A 390
SER A 447
PHE A 454
 None
None
None
DST  A 601 ( 4.4A)
None
 0.95A 2w9sB-3n0gA:
undetectable		 2w9sB-3n0gA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.20A 2zj0A-3i4xA:
undetectable		 2zj0A-3i4xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 3o2k BREVIANAMIDE F
PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 7 GLY A 196
ASP A 191
TYR A  61
ARG A 113
 None
DST  A 501 ( 4.1A)
None
DST  A 501 (-2.8A)
 1.33A 3arrA-3o2kA:
undetectable		 3arrA-3o2kA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.23A 3ce6A-3i4xA:
undetectable		 3ce6A-3i4xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.21A 3ce6C-3i4xA:
undetectable		 3ce6C-3i4xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		4 / 7 GLU A  51
TYR A 186
TYR A 235
TYR A 292
 B1C  A 403 (-2.9A)
DST  A 401 (-4.3A)
DST  A 401 (-3.4A)
None
 1.18A 3ku9B-5tu4A:
undetectable		 3ku9B-5tu4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5ygk -
(-) 		4 / 5 LEU A  48
LEU A   4
LEU A   7
MET A  29
 None
None
DST  A 301 (-4.1A)
DST  A 302 ( 4.4A)
 1.04A 3vhuA-5ygkA:
undetectable		 3vhuA-5ygkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5ygk -
(-) 		4 / 6 THR A  51
ILE A  50
THR A 193
PHE A  36
 DST  A 301 (-4.3A)
None
None
None
 1.05A 4acbC-5ygkA:
2.3		 4acbC-5ygkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		4 / 8 ASN A 231
ALA A 275
TYR A 235
ARG A 288
 None
None
DST  A 401 (-3.4A)
DST  A 401 (-4.3A)
 1.03A 4ijiF-5tu4A:
undetectable		 4ijiF-5tu4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3n0g ISOPRENE SYNTHASE
(Populus
tremula
x
Populus
alba) 		3 / 3 TYR A 438
ARG A 486
SER A 506
 None
DST  A 601 (-3.1A)
None
 0.90A 4khpI-3n0gA:
undetectable
4khpJ-3n0gA:
undetectable		 4khpI-3n0gA:
14.09
4khpJ-3n0gA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3o2k BREVIANAMIDE F
PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 TYR A 450
ARG A 113
SER A 104
 DST  A 501 ( 3.2A)
DST  A 501 (-2.8A)
DST  A 501 ( 4.9A)
 1.08A 4khpI-3o2kA:
undetectable
4khpJ-3o2kA:
undetectable		 4khpI-3o2kA:
15.32
4khpJ-3o2kA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 3n0g ISOPRENE SYNTHASE
(Populus
tremula
x
Populus
alba) 		3 / 3 TYR A 438
ARG A 486
SER A 506
 None
DST  A 601 (-3.1A)
None
 1.05A 4lf7I-3n0gA:
undetectable
4lf7J-3n0gA:
undetectable		 4lf7I-3n0gA:
13.29
4lf7J-3n0gA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 3n0g ISOPRENE SYNTHASE
(Populus
tremula
x
Populus
alba) 		3 / 3 TYR A 438
ARG A 486
SER A 506
 None
DST  A 601 (-3.1A)
None
 1.05A 4lf8I-3n0gA:
undetectable
4lf8J-3n0gA:
undetectable		 4lf8I-3n0gA:
13.29
4lf8J-3n0gA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.34A 4lvcA-3i4xA:
undetectable		 4lvcA-3i4xA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 3n0g ISOPRENE SYNTHASE
(Populus
tremula
x
Populus
alba) 		4 / 6 GLU A 502
ASP A 349
ASN A 489
ARG A 486
 None
MG  A 623 ( 3.2A)
DST  A 601 (-3.8A)
DST  A 601 (-3.1A)
 1.38A 4ntxA-3n0gA:
2.2
4ntxC-3n0gA:
undetectable		 4ntxA-3n0gA:
21.43
4ntxC-3n0gA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		3 / 3 GLU A 188
ALA A 187
PHE A 222
 B1C  A 403 ( 4.2A)
None
DST  A 401 ( 4.5A)
 0.68A 4v1fA-5tu4A:
undetectable		 4v1fA-5tu4A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		3 / 3 GLU A 188
ALA A 187
PHE A 222
 B1C  A 403 ( 4.2A)
None
DST  A 401 ( 4.5A)
 0.66A 4v1fC-5tu4A:
undetectable		 4v1fC-5tu4A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 3n0g ISOPRENE SYNTHASE
(Populus
tremula
x
Populus
alba) 		5 / 10 ASP A 345
ASP A 346
ASP A 349
ARG A 308
ASP A 490
 MG  A 623 (-3.0A)
None
MG  A 623 ( 3.2A)
DST  A 601 (-4.1A)
MG  A 622 ( 4.5A)
 1.18A 5eroC-3n0gA:
9.7		 5eroC-3n0gA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4yla AROMATIC
PRENYLTRANSFERASE
(Marinactinospora
thermotolerans) 		5 / 12 LEU A  90
HIS A  43
ALA A  56
THR A 105
PRO A 170
 None
None
None
DST  A 405 ( 3.8A)
None
 1.25A 5hnzB-4ylaA:
undetectable		 5hnzB-4ylaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3o2k BREVIANAMIDE F
PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		4 / 6 TYR A 446
ASP A 191
ILE A 112
TYR A 203
 DST  A 501 (-4.7A)
DST  A 501 ( 4.1A)
None
QRP  A 502 ( 3.4A)
 1.28A 5igyA-3o2kA:
undetectable		 5igyA-3o2kA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 3o2k BREVIANAMIDE F
PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 LYS A 294
HIS A 366
HIS A 368
 DST  A 501 (-2.9A)
None
None
 0.86A 5oexA-3o2kA:
undetectable		 5oexA-3o2kA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 3o2k BREVIANAMIDE F
PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 LYS A 294
HIS A 366
HIS A 368
 DST  A 501 (-2.9A)
None
None
 0.86A 5oexB-3o2kA:
undetectable		 5oexB-3o2kA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 3o2k BREVIANAMIDE F
PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 LYS A 294
HIS A 366
HIS A 368
 DST  A 501 (-2.9A)
None
None
 0.86A 5oexC-3o2kA:
undetectable		 5oexC-3o2kA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 3o2k BREVIANAMIDE F
PRENYLTRANSFERASE
(Aspergillus
fumigatus) 		3 / 3 LYS A 294
HIS A 366
HIS A 368
 DST  A 501 (-2.9A)
None
None
 0.89A 5oexD-3o2kA:
undetectable		 5oexD-3o2kA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.35A 6gbnA-3i4xA:
undetectable		 6gbnA-3i4xA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.36A 6gbnD-3i4xA:
undetectable		 6gbnD-3i4xA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		3 / 3 ARG A 100
LYS A 180
TYR A  46
 DST  A 460 (-3.0A)
None
None
 1.37A 6gnaA-3i4xA:
undetectable		 6gnaA-3i4xA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		3 / 3 ARG A 100
LYS A 180
TYR A  46
 DST  A 460 (-3.0A)
None
None
 1.37A 6gnbA-3i4xA:
undetectable		 6gnbA-3i4xA:
21.81