SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DSN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 1uhg OVALBUMIN
(Gallus
gallus) 		4 / 5 LEU A 321
LEU A 312
LEU A  43
MET A 172
 DSN  A 320 ( 4.6A)
None
None
None
 1.11A 2oaxF-1uhgA:
undetectable		 2oaxF-1uhgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 7 ASP A 222
SER A 123
TYR A 250
ARG A 128
 DSN  A 901 (-3.0A)
DSN  A 901 (-2.7A)
DSN  A 901 (-4.7A)
DSN  A 901 (-3.0A)
 0.94A 3pglA-2rcbA:
undetectable		 3pglA-2rcbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		3 / 3 TYR A 250
ASP A 227
ASP A 222
 DSN  A 901 (-4.7A)
None
DSN  A 901 (-3.0A)
 0.84A 3r24A-2rcbA:
undetectable		 3r24A-2rcbA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		5 / 12 GLY A 144
LEU A 225
LEU A 226
ALA A 246
TYR A  95
 None
None
None
None
DSN  A 901 (-3.3A)
 1.10A 4lg1B-2rcbA:
undetectable		 4lg1B-2rcbA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		5 / 12 GLY A 144
LEU A 225
LEU A 226
ALA A 246
TYR A  95
 None
None
None
None
DSN  A 901 (-3.3A)
 1.15A 4lg1C-2rcbA:
undetectable		 4lg1C-2rcbA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 8 ILE A 157
GLY A 144
THR A 141
SER A 123
 None
None
None
DSN  A 901 (-2.7A)
 0.83A 4r20A-2rcbA:
undetectable		 4r20A-2rcbA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B
(Rattus
norvegicus) 		4 / 6 TYR A  95
VAL A  10
VAL A 119
THR A 120
 DSN  A 901 (-3.3A)
None
None
None
 1.31A 6f32B-2rcbA:
undetectable		 6f32B-2rcbA:
22.43