SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DSH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		6 / 12 GLY A 101
GLY A 103
GLU A 124
ASP A 155
GLY A 156
LEU A 184
 DSH  A 303 (-3.4A)
DSH  A 303 (-3.5A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
DSH  A 303 (-4.2A)
 0.74A 1jg2A-3rw9A:
7.8		 1jg2A-3rw9A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		6 / 11 GLY A 101
GLY A 103
GLU A 124
ASP A 155
GLY A 156
LEU A 184
 DSH  A 303 (-3.4A)
DSH  A 303 (-3.5A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
DSH  A 303 (-4.2A)
 0.77A 1jg3A-3rw9A:
7.5		 1jg3A-3rw9A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		6 / 11 GLY A 101
GLY A 103
GLU A 124
ASP A 155
GLY A 156
LEU A 184
 DSH  A 303 (-3.4A)
DSH  A 303 (-3.5A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
DSH  A 303 (-4.2A)
 0.77A 1jg3B-3rw9A:
7.7		 1jg3B-3rw9A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		4 / 6 TYR A  79
GLU A 208
ILE A 100
GLY A 102
 DSH  A 303 ( 4.9A)
None
None
DSH  A 303 ( 4.7A)
 1.14A 1maaB-3rw9A:
undetectable
1maaD-3rw9A:
undetectable		 1maaB-3rw9A:
21.64
1maaD-3rw9A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 103
GLY A 105
GLY A 106
ASP A 126
VAL A 129
 DSH  A 303 (-3.5A)
None
None
None
DSH  A 303 (-4.5A)
 0.81A 1n2xB-3rw9A:
12.7		 1n2xB-3rw9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 101
GLY A 103
ILE A 125
ASP A 126
ASP A 155
 DSH  A 303 (-3.4A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.8A)
None
DSH  A 303 (-3.5A)
 0.61A 1qaoA-3rw9A:
9.3		 1qaoA-3rw9A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 101
GLY A 102
GLY A 103
GLU A 124
ASP A 155
 DSH  A 303 (-3.4A)
DSH  A 303 ( 4.7A)
DSH  A 303 (-3.5A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.5A)
 0.76A 1qzzA-3rw9A:
11.7		 1qzzA-3rw9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		6 / 12 GLY A 105
GLY A 106
ILE A 125
ASP A 126
ASP A 155
GLY A 156
 None
None
DSH  A 303 (-3.8A)
None
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
 0.53A 1sqfA-3rw9A:
9.1		 1sqfA-3rw9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 101
GLY A 102
GLY A 103
GLU A 124
ASP A 155
 DSH  A 303 (-3.4A)
DSH  A 303 ( 4.7A)
DSH  A 303 (-3.5A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.5A)
 0.79A 1xdsA-3rw9A:
10.4		 1xdsA-3rw9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 101
GLY A 102
GLY A 103
GLU A 124
ASP A 155
 DSH  A 303 (-3.4A)
DSH  A 303 ( 4.7A)
DSH  A 303 (-3.5A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.5A)
 0.79A 1xdsB-3rw9A:
11.1		 1xdsB-3rw9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 THR A 172
ASP A 155
GLY A 207
ILE A 246
TYR A  79
 None
DSH  A 303 (-3.5A)
None
None
DSH  A 303 ( 4.9A)
 1.48A 1xvaA-3rw9A:
10.6		 1xvaA-3rw9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		3 / 3 GLY A 101
GLU A 124
ASP A 173
 DSH  A 303 (-3.4A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.0A)
 0.61A 2b25B-3rw9A:
9.7		 2b25B-3rw9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 101
GLU A 124
ILE A 125
ASP A 173
 DSH  A 303 (-3.4A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.8A)
DSH  A 303 (-3.0A)
 0.74A 3a7eA-3rw9A:
11.8		 3a7eA-3rw9A:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLN A  70
ASP A 104
TYR A 241
PRO A 242
ILE A 238
 DSH  A 303 (-4.1A)
DSH  A 303 (-3.3A)
None
None
None
 1.47A 3b7pA-3rw9A:
41.9		 3b7pA-3rw9A:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLN A  70
TYR A  79
ASP A 104
ASP A 173
GLU A 208
TYR A 241
ILE A 246
 DSH  A 303 (-4.1A)
DSH  A 303 ( 4.9A)
DSH  A 303 (-3.3A)
DSH  A 303 (-3.0A)
None
None
None
 1.04A 3b7pA-3rw9A:
41.9		 3b7pA-3rw9A:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLN A 206
ASP A 173
TYR A 241
PRO A 242
ILE A 238
 None
DSH  A 303 (-3.0A)
None
None
None
 1.42A 3b7pA-3rw9A:
41.9		 3b7pA-3rw9A:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		9 / 12 TRP A  28
GLN A  70
TYR A  79
ASP A 104
ASP A 173
GLN A 206
TYR A 241
PRO A 242
ILE A 246
 None
DSH  A 303 (-4.1A)
DSH  A 303 ( 4.9A)
DSH  A 303 (-3.3A)
DSH  A 303 (-3.0A)
None
None
None
None
 0.64A 3b7pA-3rw9A:
41.9		 3b7pA-3rw9A:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLN A  70
TYR A  79
ASP A 104
ASP A 173
GLU A 208
TYR A 241
ILE A 246
 DSH  A 303 (-4.1A)
DSH  A 303 ( 4.9A)
DSH  A 303 (-3.3A)
DSH  A 303 (-3.0A)
None
None
None
 1.00A 3b7pB-3rw9A:
42.8		 3b7pB-3rw9A:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		9 / 12 TRP A  28
GLN A  70
TYR A  79
ASP A 104
ASP A 173
GLN A 206
TYR A 241
PRO A 242
ILE A 246
 None
DSH  A 303 (-4.1A)
DSH  A 303 ( 4.9A)
DSH  A 303 (-3.3A)
DSH  A 303 (-3.0A)
None
None
None
None
 0.65A 3b7pB-3rw9A:
42.8		 3b7pB-3rw9A:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLN A  70
ASP A 104
TYR A 241
PRO A 242
ILE A 238
 DSH  A 303 (-4.1A)
DSH  A 303 (-3.3A)
None
None
None
 1.48A 3b7pC-3rw9A:
42.6		 3b7pC-3rw9A:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLN A 206
ASP A 173
TYR A 241
PRO A 242
ILE A 238
 None
DSH  A 303 (-3.0A)
None
None
None
 1.41A 3b7pC-3rw9A:
42.6		 3b7pC-3rw9A:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		8 / 12 TRP A  28
GLN A  70
TYR A  79
ASP A 104
ASP A 173
TYR A 241
PRO A 242
ILE A 246
 None
DSH  A 303 (-4.1A)
DSH  A 303 ( 4.9A)
DSH  A 303 (-3.3A)
DSH  A 303 (-3.0A)
None
None
None
 0.50A 3b7pC-3rw9A:
42.6		 3b7pC-3rw9A:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		9 / 12 GLN A  49
TYR A  79
ILE A 100
GLY A 101
ILE A 125
ASP A 126
VAL A 129
ASP A 155
GLY A 156
 DSH  A 303 (-3.6A)
DSH  A 303 ( 4.9A)
None
DSH  A 303 (-3.4A)
DSH  A 303 (-3.8A)
None
DSH  A 303 (-4.5A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
 0.54A 3bwcA-3rw9A:
39.7		 3bwcA-3rw9A:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		7 / 12 GLN A  49
TYR A  79
ILE A 125
VAL A 129
ASP A 155
GLY A 156
GLN A 206
 DSH  A 303 (-3.6A)
DSH  A 303 ( 4.9A)
DSH  A 303 (-3.8A)
DSH  A 303 (-4.5A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
None
 0.71A 3bwcA-3rw9A:
39.7		 3bwcA-3rw9A:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		7 / 12 LEU A  65
TYR A  79
ASP A 104
VAL A 129
GLY A 156
ASP A 173
GLN A 206
 None
DSH  A 303 ( 4.9A)
DSH  A 303 (-3.3A)
DSH  A 303 (-4.5A)
DSH  A 303 (-3.7A)
DSH  A 303 (-3.0A)
None
 0.73A 3bwcB-3rw9A:
39.1		 3bwcB-3rw9A:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A  65
TYR A  79
GLY A 102
ASP A 126
VAL A 129
ASP A 173
 None
DSH  A 303 ( 4.9A)
DSH  A 303 ( 4.7A)
None
DSH  A 303 (-4.5A)
DSH  A 303 (-3.0A)
 1.14A 3bwcB-3rw9A:
39.1		 3bwcB-3rw9A:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		10 / 12 LEU A  65
TYR A  79
ILE A 100
GLY A 101
ASP A 104
ILE A 125
ASP A 126
VAL A 129
GLY A 156
ASP A 173
 None
DSH  A 303 ( 4.9A)
None
DSH  A 303 (-3.4A)
DSH  A 303 (-3.3A)
DSH  A 303 (-3.8A)
None
DSH  A 303 (-4.5A)
DSH  A 303 (-3.7A)
DSH  A 303 (-3.0A)
 0.45A 3bwcB-3rw9A:
39.1		 3bwcB-3rw9A:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 101
GLY A 103
GLU A 124
ASP A 126
ASP A 155
 DSH  A 303 (-3.4A)
DSH  A 303 (-3.5A)
DSH  A 303 (-2.6A)
None
DSH  A 303 (-3.5A)
 0.53A 3fuuA-3rw9A:
11.2		 3fuuA-3rw9A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 11 GLY A 101
GLU A 124
ILE A 125
ASP A 126
ASP A 155
 DSH  A 303 (-3.4A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.8A)
None
DSH  A 303 (-3.5A)
 0.44A 3grvA-3rw9A:
12.2		 3grvA-3rw9A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 101
GLU A 124
ILE A 125
ASP A 126
ASP A 155
 DSH  A 303 (-3.4A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.8A)
None
DSH  A 303 (-3.5A)
 0.50A 3gryA-3rw9A:
12.0		 3gryA-3rw9A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 105
GLY A 106
ASP A 126
ASP A 173
LEU A 184
 None
None
None
DSH  A 303 (-3.0A)
DSH  A 303 (-4.2A)
 0.69A 3m6vA-3rw9A:
9.9		 3m6vA-3rw9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 105
GLY A 106
ASP A 126
ASP A 173
LEU A 184
 None
None
None
DSH  A 303 (-3.0A)
DSH  A 303 (-4.2A)
 0.68A 3m6vB-3rw9A:
9.8		 3m6vB-3rw9A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		4 / 4 GLY A 101
GLU A 124
ASP A 155
ASP A 173
 DSH  A 303 (-3.4A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.0A)
 0.68A 3mb5A-3rw9A:
12.9		 3mb5A-3rw9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 142
GLY A 105
ASP A 173
VAL A  97
LEU A  88
 None
None
DSH  A 303 (-3.0A)
None
None
 1.13A 3v8vA-3rw9A:
9.9		 3v8vA-3rw9A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 103
GLU A 124
ASP A 155
ASP A 173
 DSH  A 303 (-3.5A)
DSH  A 303 (-2.6A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.0A)
 0.73A 3vywC-3rw9A:
13.4		 3vywC-3rw9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		4 / 8 PHE A 159
HIS A 152
GLU A 124
ILE A 100
 None
None
DSH  A 303 (-2.6A)
None
 1.36A 4cx7A-3rw9A:
undetectable
4cx7B-3rw9A:
undetectable		 4cx7A-3rw9A:
20.85
4cx7B-3rw9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 105
GLY A 106
GLY A 156
ASP A 173
LEU A 184
 None
None
DSH  A 303 (-3.7A)
DSH  A 303 (-3.0A)
DSH  A 303 (-4.2A)
 0.82A 4fp9A-3rw9A:
9.7		 4fp9A-3rw9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 105
GLY A 106
GLY A 156
ASP A 173
LEU A 184
 None
None
DSH  A 303 (-3.7A)
DSH  A 303 (-3.0A)
DSH  A 303 (-4.2A)
 0.82A 4fp9C-3rw9A:
9.7		 4fp9C-3rw9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 105
GLY A 106
ASP A 155
GLY A 156
LEU A 184
 None
None
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
DSH  A 303 (-4.2A)
 0.66A 4fp9D-3rw9A:
9.6		 4fp9D-3rw9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 105
GLY A 106
GLY A 156
ASP A 173
LEU A 184
 None
None
DSH  A 303 (-3.7A)
DSH  A 303 (-3.0A)
DSH  A 303 (-4.2A)
 0.82A 4fp9F-3rw9A:
9.7		 4fp9F-3rw9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 105
GLY A 106
ASP A 155
GLY A 156
LEU A 184
 None
None
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
DSH  A 303 (-4.2A)
 0.62A 4fzvA-3rw9A:
9.5		 4fzvA-3rw9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		3 / 3 GLU A 124
ASP A 126
ASP A 155
 DSH  A 303 (-2.6A)
None
DSH  A 303 (-3.5A)
 0.36A 4gc9A-3rw9A:
9.6		 4gc9A-3rw9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 CYH A 205
TYR A 233
GLY A 207
ILE A 246
TYR A  79
 None
None
None
None
DSH  A 303 ( 4.9A)
 1.29A 4kosA-3rw9A:
undetectable		 4kosA-3rw9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 CYH A 205
TYR A 233
GLY A 207
ILE A 246
TYR A  79
 None
None
None
None
DSH  A 303 ( 4.9A)
 1.27A 4kotA-3rw9A:
0.8		 4kotA-3rw9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 11 CYH A 205
TYR A 233
GLY A 207
ILE A 246
TYR A  79
 None
None
None
None
DSH  A 303 ( 4.9A)
 1.25A 4koyA-3rw9A:
2.1		 4koyA-3rw9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		4 / 7 GLY A 101
GLY A 103
ASP A 155
ASP A 173
 DSH  A 303 (-3.4A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.0A)
 0.68A 5ergB-3rw9A:
8.9		 5ergB-3rw9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 106
ASP A 155
GLY A 156
ASP A 173
LEU A 184
 None
DSH  A 303 (-3.5A)
DSH  A 303 (-3.7A)
DSH  A 303 (-3.0A)
DSH  A 303 (-4.2A)
 1.04A 5wwsA-3rw9A:
9.6		 5wwsA-3rw9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 105
GLY A 143
ILE A 100
GLY A 103
GLY A 102
 None
None
None
DSH  A 303 (-3.5A)
DSH  A 303 ( 4.7A)
 1.09A 5wyqA-3rw9A:
undetectable		 5wyqA-3rw9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLN A  49
GLY A 101
ASP A 126
VAL A 129
ALA A 181
 DSH  A 303 (-3.6A)
DSH  A 303 (-3.4A)
None
DSH  A 303 (-4.5A)
DSH  A 303 (-3.8A)
 0.98A 6bq4A-3rw9A:
33.3		 6bq4A-3rw9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		6 / 12 GLN A  49
GLY A 101
ILE A 125
ASP A 126
VAL A 129
ASP A 155
 DSH  A 303 (-3.6A)
DSH  A 303 (-3.4A)
DSH  A 303 (-3.8A)
None
DSH  A 303 (-4.5A)
DSH  A 303 (-3.5A)
 0.61A 6bq4A-3rw9A:
33.3		 6bq4A-3rw9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 101
ILE A 125
ASP A 126
ASP A 155
LEU A 184
 DSH  A 303 (-3.4A)
DSH  A 303 (-3.8A)
None
DSH  A 303 (-3.5A)
DSH  A 303 (-4.2A)
 0.63A 6bq4A-3rw9A:
33.3		 6bq4A-3rw9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLN A  49
GLY A 101
ASP A 126
VAL A 129
ALA A 181
 DSH  A 303 (-3.6A)
DSH  A 303 (-3.4A)
None
DSH  A 303 (-4.5A)
DSH  A 303 (-3.8A)
 0.93A 6bq4B-3rw9A:
33.4		 6bq4B-3rw9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		6 / 12 GLN A  49
GLY A 101
ILE A 125
ASP A 126
VAL A 129
ASP A 155
 DSH  A 303 (-3.6A)
DSH  A 303 (-3.4A)
DSH  A 303 (-3.8A)
None
DSH  A 303 (-4.5A)
DSH  A 303 (-3.5A)
 0.53A 6bq4B-3rw9A:
33.4		 6bq4B-3rw9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 101
ILE A 125
ASP A 126
ASP A 155
PRO A 180
 DSH  A 303 (-3.4A)
DSH  A 303 (-3.8A)
None
DSH  A 303 (-3.5A)
DSH  A 303 (-4.5A)
 0.71A 6bq4B-3rw9A:
33.4		 6bq4B-3rw9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 102
SER A  46
GLN A  49
ILE A 125
ASP A 155
 DSH  A 303 ( 4.7A)
None
DSH  A 303 (-3.6A)
DSH  A 303 (-3.8A)
DSH  A 303 (-3.5A)
 1.23A 6bxnB-3rw9A:
3.1		 6bxnB-3rw9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A 108
GLY A 101
ILE A 170
VAL A 111
VAL A 107
 None
DSH  A 303 (-3.4A)
None
None
None
 0.94A 6dh0A-3rw9A:
undetectable		 6dh0A-3rw9A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A 100
GLY A 101
GLY A 103
ILE A 125
ASP A 126
 None
DSH  A 303 (-3.4A)
DSH  A 303 (-3.5A)
DSH  A 303 (-3.8A)
None
 0.66A 6iftA-3rw9A:
9.6		 6iftA-3rw9A:
25.00