SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DRK'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
5 / 12 ILE A 162
SER A 227
ILE A 167
ASN A 171
LEU A 183
None
None
None
DRK  A 384 ( 4.6A)
None
1.02A 1dlsA-3eb0A:
undetectable
1dlsA-3eb0A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 9 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LEU A 173
TYR A 119
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
DRK  A 384 (-3.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
1.39A 1muoA-3eb0A:
18.7
1muoA-3eb0A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 9 LEU A  15
GLY A  16
VAL A  23
ALA A  36
TYR A 119
LEU A 173
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
DRK  A 384 (-3.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
0.99A 1muoA-3eb0A:
18.7
1muoA-3eb0A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
4 / 5 ILE A 168
LEU A 167
VAL A 132
ALA A 276
DRK  A   1 ( 4.2A)
None
None
None
0.95A 1mz9C-3f3zA:
undetectable
1mz9C-3f3zA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
4 / 6 ILE A  34
VAL A  42
ILE A  85
ASP A 169
DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
None
None
0.74A 1uwhA-3f3zA:
14.7
1uwhA-3f3zA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
4 / 6 ILE A  34
VAL A  42
ILE A  85
ASP A 169
DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
None
None
0.74A 1uwhB-3f3zA:
8.7
1uwhB-3f3zA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
5 / 9 VAL A  42
LYS A  57
LEU A  88
LEU A 100
LEU A 104
DRK  A   1 ( 4.9A)
DRK  A   1 (-4.1A)
None
None
DRK  A   1 (-4.4A)
0.54A 1xkkA-3f3zA:
22.2
1xkkA-3f3zA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
TYR A 119
ASN A 171
ASP A 185
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
DRK  A 384 (-3.5A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.6A)
DRK  A 384 ( 4.7A)
1.02A 2fumB-3eb0A:
25.4
2fumB-3eb0A:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 12 LEU A  15
VAL A  23
ALA A  36
MET A 117
TYR A 119
ASN A 171
ASP A 185
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.6A)
DRK  A 384 ( 4.7A)
0.89A 2fumB-3eb0A:
25.4
2fumB-3eb0A:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 12 LEU A  15
GLY A  16
GLY A  18
VAL A  23
ALA A  36
MET A 117
ASP A 185
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
None
DRK  A 384 (-3.5A)
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.7A)
0.88A 2fumD-3eb0A:
17.4
2fumD-3eb0A:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
8 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A 117
LYS A 168
ASN A 171
ASP A 185
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
DRK  A 384 (-3.5A)
DRK  A 384 (-3.8A)
None
DRK  A 384 ( 4.6A)
DRK  A 384 ( 4.7A)
0.89A 2fumD-3eb0A:
17.4
2fumD-3eb0A:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
8 / 12 LEU A  15
VAL A  23
ALA A  36
MET A 117
THR A 123
LYS A 168
ASN A 171
ASP A 185
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.5A)
None
DRK  A 384 ( 4.6A)
DRK  A 384 ( 4.7A)
1.00A 2fumD-3eb0A:
17.4
2fumD-3eb0A:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 12 LEU A  15
GLY A  16
VAL A  23
LYS A  38
GLU A  50
TYR A 119
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
None
None
DRK  A 384 (-4.4A)
0.49A 2ivuA-3eb0A:
23.3
2ivuA-3eb0A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 12 VAL A  23
ALA A  36
LYS A  38
GLU A  50
MET A  54
TYR A 119
LEU A 173
None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
0.75A 2oiqA-3eb0A:
21.8
2oiqA-3eb0A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 12 VAL A  23
ALA A  36
LYS A  38
GLU A  50
MET A  54
TYR A 119
LEU A 173
None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
0.93A 2pl0A-3eb0A:
20.8
2pl0A-3eb0A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
8 / 12 ILE A  34
VAL A  42
ALA A  55
ILE A  86
LEU A 104
GLY A 108
GLU A 109
LEU A 155
DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-4.4A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.6A)
0.82A 2y7jA-3f3zA:
30.1
2y7jA-3f3zA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
6 / 10 ILE A  34
VAL A  42
ALA A  55
ILE A  86
LEU A 104
LEU A 155
DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-4.4A)
DRK  A   1 (-4.6A)
0.59A 2y7jB-3f3zA:
35.0
2y7jB-3f3zA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
6 / 10 ILE A  34
VAL A  42
ALA A  55
ILE A  86
LEU A 104
LEU A 155
DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-4.4A)
DRK  A   1 (-4.6A)
0.60A 2y7jC-3f3zA:
30.4
2y7jC-3f3zA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
6 / 10 ILE A  34
VAL A  42
ALA A  55
ILE A  86
LEU A 104
LEU A 155
DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-4.4A)
DRK  A   1 (-4.6A)
0.63A 2y7jD-3f3zA:
30.4
2y7jD-3f3zA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
4 / 6 LEU A  15
VAL A  23
LYS A  38
LEU A 173
DRK  A 384 (-3.8A)
None
None
DRK  A 384 (-4.4A)
0.38A 3cs9D-3eb0A:
20.6
3cs9D-3eb0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
8 / 12 LEU A  15
GLY A  16
GLY A  18
GLY A  21
VAL A  23
ALA A  36
MET A 117
TYR A 119
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
None
None
DRK  A 384 (-3.5A)
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
0.73A 3fupA-3eb0A:
23.7
3fupA-3eb0A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
8 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
MET A 117
TYR A 119
ASP A 185
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
DRK  A 384 (-3.5A)
None
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.7A)
0.75A 3fupA-3eb0A:
23.7
3fupA-3eb0A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
8 / 12 LEU A  15
GLY A  16
GLY A  18
ALA A  36
LYS A  38
MET A 117
TYR A 119
ASP A 185
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
DRK  A 384 (-3.5A)
None
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.7A)
0.81A 3fupB-3eb0A:
23.7
3fupB-3eb0A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  50
MET A  54
LEU A 173
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
DRK  A 384 (-4.4A)
0.73A 3gvuA-3eb0A:
21.3
3gvuA-3eb0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
4 / 8 ALA A  55
LYS A  57
LEU A 100
LEU A 104
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
None
DRK  A   1 (-4.4A)
0.34A 3lfaA-3f3zA:
19.3
3lfaA-3f3zA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
8 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
MET A 117
TYR A 119
ASP A 185
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
DRK  A 384 (-3.5A)
None
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.7A)
0.93A 3lxkA-3eb0A:
23.5
3lxkA-3eb0A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
MET A 117
TYR A 119
LEU A 173
ASP A 185
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.7A)
0.96A 3lxkA-3eb0A:
23.5
3lxkA-3eb0A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
ILE A  63
TYR A 119
LEU A 173
ASP A 185
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.7A)
0.79A 3lxnA-3eb0A:
23.6
3lxnA-3eb0A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  50
MET A  54
LEU A 173
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
DRK  A 384 (-4.4A)
0.65A 3ms9A-3eb0A:
20.9
3ms9A-3eb0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  50
MET A  54
LEU A 173
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
DRK  A 384 (-4.4A)
0.64A 3mssA-3eb0A:
21.0
3mssA-3eb0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  50
MET A  54
LEU A 173
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
DRK  A 384 (-4.4A)
0.63A 3mssC-3eb0A:
21.0
3mssC-3eb0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
6 / 12 ILE A  34
VAL A  42
ALA A  55
LYS A  57
CYH A 105
PHE A 170
DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 (-4.1A)
None
1.02A 3og7A-3f3zA:
18.2
3og7A-3f3zA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  50
MET A  54
LEU A 173
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
DRK  A 384 (-4.4A)
0.71A 3pyyA-3eb0A:
21.4
3pyyA-3eb0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  50
MET A  54
LEU A 173
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
DRK  A 384 (-4.4A)
0.73A 3pyyB-3eb0A:
21.3
3pyyB-3eb0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
7 / 12 ILE A  34
GLY A  37
GLY A  40
VAL A  42
ALA A  55
LYS A  57
LEU A 155
DRK  A   1 (-4.2A)
None
None
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 (-4.6A)
0.58A 3v5wA-3f3zA:
10.8
3v5wA-3f3zA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
4 / 8 VAL A  42
LYS A  57
ILE A  86
ILE A 168
DRK  A   1 ( 4.9A)
DRK  A   1 (-4.1A)
DRK  A   1 ( 4.8A)
DRK  A   1 ( 4.2A)
0.55A 3warA-3f3zA:
26.5
3warA-3f3zA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 9 ILE A  53
MET A  54
LEU A  57
ILE A  62
ILE A  63
TYR A 119
None
None
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
0.56A 3zosA-3eb0A:
21.1
3zosA-3eb0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 9 LEU A  15
ILE A  53
MET A  54
LEU A  57
ILE A  62
TYR A 119
DRK  A 384 (-3.8A)
None
None
None
None
DRK  A 384 (-4.4A)
0.50A 3zosB-3eb0A:
21.0
3zosB-3eb0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  50
LEU A 173
CYH A 184
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
DRK  A 384 (-4.4A)
DRK  A 384 ( 3.8A)
0.68A 4ag8A-3eb0A:
21.0
4ag8A-3eb0A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 12 VAL A  23
ALA A  36
GLU A  50
ILE A  53
MET A  54
ILE A  63
LEU A 173
None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
0.64A 4bkjA-3eb0A:
20.8
4bkjA-3eb0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 12 VAL A  23
ALA A  36
GLU A  50
ILE A  53
MET A  54
TYR A 119
LEU A 173
None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
0.81A 4bkjA-3eb0A:
20.8
4bkjA-3eb0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 12 VAL A  23
ALA A  36
GLU A  50
ILE A  53
MET A  54
ILE A  63
LEU A 173
None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
0.78A 4bkjB-3eb0A:
20.9
4bkjB-3eb0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 11 LEU A  15
GLY A  16
GLY A  18
VAL A  23
ALA A  36
TYR A 119
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
None
DRK  A 384 (-3.5A)
DRK  A 384 (-4.4A)
0.81A 4ckiA-3eb0A:
23.7
4ckiA-3eb0A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 12 VAL A  23
ALA A  36
GLU A  50
ILE A  53
MET A  54
TYR A 119
LEU A 173
None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
0.72A 4csvA-3eb0A:
22.3
4csvA-3eb0A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
5 / 12 ILE A 162
SER A 227
ILE A 167
ASN A 171
LEU A 183
None
None
None
DRK  A 384 ( 4.6A)
None
0.83A 4gh8A-3eb0A:
undetectable
4gh8A-3eb0A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
6 / 11 VAL A  42
ALA A  55
LYS A  57
LEU A 155
ILE A 168
ASP A 169
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 (-4.6A)
DRK  A   1 ( 4.2A)
None
0.96A 4iaaA-3f3zA:
21.9
4iaaA-3f3zA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
7 / 12 GLY A  35
VAL A  42
ALA A  55
LEU A  88
LEU A 100
GLY A 108
ILE A 168
DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
None
None
DRK  A   1 ( 4.9A)
DRK  A   1 ( 4.2A)
0.56A 4ifgA-3f3zA:
29.5
4ifgA-3f3zA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
7 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A 100
GLY A 108
ILE A 168
DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
None
DRK  A   1 ( 4.9A)
DRK  A   1 ( 4.2A)
0.64A 4ifgA-3f3zA:
29.5
4ifgA-3f3zA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
8 / 12 VAL A  42
ALA A  55
LEU A  88
LEU A 100
GLY A 108
GLU A 109
LEU A 155
ILE A 168
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
None
None
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.6A)
DRK  A   1 ( 4.2A)
0.53A 4ifgA-3f3zA:
29.5
4ifgA-3f3zA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
7 / 12 VAL A  42
ALA A  55
LYS A  57
LEU A 100
GLY A 108
LEU A 155
ILE A 168
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
None
DRK  A   1 ( 4.9A)
DRK  A   1 (-4.6A)
DRK  A   1 ( 4.2A)
0.58A 4ifgA-3f3zA:
29.5
4ifgA-3f3zA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
4 / 7 VAL A  42
ALA A  55
MET A 102
LEU A 155
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-3.6A)
DRK  A   1 (-4.6A)
0.44A 4l9iA-3f3zA:
25.1
4l9iA-3f3zA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
5 / 8 GLY A  18
VAL A  23
ALA A  36
LYS A  38
MET A 117
None
None
DRK  A 384 (-3.5A)
None
DRK  A 384 (-3.8A)
0.57A 4l9iB-3eb0A:
24.3
4l9iB-3eb0A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
6 / 8 GLY A  37
VAL A  42
ALA A  55
LYS A  57
MET A 102
LEU A 155
None
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 (-3.6A)
DRK  A   1 (-4.6A)
0.86A 4l9iB-3f3zA:
22.1
4l9iB-3f3zA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  50
MET A  54
TYR A 119
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 (-4.4A)
0.64A 4mxoA-3eb0A:
23.1
4mxoA-3eb0A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
4 / 6 VAL A  23
ALA A  36
THR A 123
LEU A 173
None
DRK  A 384 (-3.5A)
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
0.64A 4o0uA-3eb0A:
19.4
4o0uA-3eb0A:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
5 / 6 LEU A  15
VAL A  23
ALA A  36
THR A 123
LEU A 173
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
0.81A 4o0wA-3eb0A:
25.7
4o0wA-3eb0A:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
5 / 8 VAL A  23
ALA A  36
ASN A 171
LEU A 173
ASP A 185
None
DRK  A 384 (-3.5A)
DRK  A 384 ( 4.6A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.7A)
0.59A 4ogrA-3eb0A:
30.0
4ogrA-3eb0A:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
6 / 12 ILE A  34
GLY A  35
VAL A  42
ALA A  55
MET A 102
LEU A 155
DRK  A   1 (-4.2A)
DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-3.6A)
DRK  A   1 (-4.6A)
0.67A 4qmzA-3f3zA:
22.8
4qmzA-3f3zA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
7 / 12 VAL A  42
ALA A  55
LYS A  57
MET A  77
CYH A 105
LEU A 155
ASP A 169
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
None
DRK  A   1 (-4.1A)
DRK  A   1 (-4.6A)
None
0.77A 4r7iA-3f3zA:
21.7
4r7iA-3f3zA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
6 / 10 ILE A  34
ALA A  55
LYS A  57
ILE A  86
LEU A 104
LEU A 155
DRK  A   1 (-4.2A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-4.4A)
DRK  A   1 (-4.6A)
0.52A 4rz7A-3f3zA:
11.3
4rz7A-3f3zA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
4 / 6 LEU A  15
VAL A  23
LYS A  38
ILE A  62
DRK  A 384 (-3.8A)
None
None
None
0.63A 4tyjA-3eb0A:
21.2
4tyjA-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 10 LEU A  15
VAL A  23
GLU A  50
ILE A  62
VAL A 115
TYR A 119
DRK  A 384 (-3.8A)
None
None
None
None
DRK  A 384 (-4.4A)
0.60A 4u0iA-3eb0A:
20.9
4u0iA-3eb0A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
4 / 7 VAL A  23
LYS A  38
MET A  54
ILE A  63
None
None
None
DRK  A 384 ( 4.5A)
0.73A 4uxqA-3eb0A:
21.0
4uxqA-3eb0A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 9 LEU A  15
VAL A  23
LYS A  38
ILE A  63
TYR A 119
ILE A  62
DRK  A 384 (-3.8A)
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
None
1.17A 4v01A-3eb0A:
20.3
4v01A-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 9 LEU A  15
VAL A  23
LYS A  38
ILE A  63
TYR A 119
LEU A 173
DRK  A 384 (-3.8A)
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
0.80A 4v01A-3eb0A:
20.3
4v01A-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 9 LEU A  15
VAL A  23
LYS A  38
ILE A  63
TYR A 119
LEU A 173
ILE A  62
DRK  A 384 (-3.8A)
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
None
1.43A 4v01B-3eb0A:
20.8
4v01B-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
4 / 8 LYS A  38
MET A  54
ILE A  63
LEU A 173
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
0.67A 4v04A-3eb0A:
20.4
4v04A-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
4 / 8 LYS A  38
MET A  54
ILE A  63
TYR A 119
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
0.70A 4v04A-3eb0A:
20.4
4v04A-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 10 LEU A  15
VAL A  23
LYS A  38
ILE A  63
TYR A 119
LEU A 173
ILE A  62
DRK  A 384 (-3.8A)
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
None
1.24A 4v04B-3eb0A:
20.8
4v04B-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 10 LEU A  15
VAL A  23
LYS A  38
MET A  54
ILE A  63
TYR A 119
LEU A 173
DRK  A 384 (-3.8A)
None
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
0.82A 4v04B-3eb0A:
20.8
4v04B-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
4 / 8 LEU A  15
ALA A  36
MET A 117
LEU A 173
DRK  A 384 (-3.8A)
DRK  A 384 (-3.5A)
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
0.67A 4wboB-3eb0A:
24.3
4wboB-3eb0A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
4 / 6 LEU A  15
ALA A  36
MET A 117
LEU A 173
DRK  A 384 (-3.8A)
DRK  A 384 (-3.5A)
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
0.67A 4wboC-3eb0A:
24.5
4wboC-3eb0A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  50
MET A  54
ILE A  63
LEU A 173
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
0.71A 5bvwA-3eb0A:
12.3
5bvwA-3eb0A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  50
MET A  54
TYR A 119
LEU A 173
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
0.83A 5bvwA-3eb0A:
12.3
5bvwA-3eb0A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 12 ALA A  36
ILE A  63
TYR A 119
CYH A 184
PHE A 186
GLY A 187
DRK  A 384 (-3.5A)
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 3.8A)
None
None
1.09A 5hesA-3eb0A:
5.8
5hesA-3eb0A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 12 VAL A  23
ALA A  36
ILE A  63
TYR A 119
CYH A 184
PHE A 186
None
DRK  A 384 (-3.5A)
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 3.8A)
None
1.02A 5hesA-3eb0A:
5.8
5hesA-3eb0A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
4 / 7 GLY A  16
LEU A  65
ASP A 185
PHE A 186
DRK  A 384 ( 4.4A)
None
DRK  A 384 ( 4.7A)
None
0.82A 5hieB-3eb0A:
6.6
5hieB-3eb0A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
4 / 7 GLY A  37
CYH A 105
ASP A 169
PHE A 170
None
DRK  A   1 (-4.1A)
None
None
0.84A 5hieB-3f3zA:
23.1
5hieB-3f3zA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
4 / 8 GLY A  37
CYH A 105
ASP A 169
PHE A 170
None
DRK  A   1 (-4.1A)
None
None
0.86A 5hieD-3f3zA:
23.3
5hieD-3f3zA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
5 / 9 LEU A 172
ILE A 228
ILE A  62
GLU A 118
VAL A 120
None
None
None
None
DRK  A 384 (-4.5A)
1.42A 5igzA-3eb0A:
7.5
5igzA-3eb0A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
5 / 7 GLY A  35
GLY A  37
SER A  38
GLY A  40
VAL A  42
DRK  A   1 ( 3.9A)
None
None
None
DRK  A   1 ( 4.9A)
0.76A 5izjB-3f3zA:
30.0
5izjB-3f3zA:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
5 / 9 GLY A  35
VAL A  42
ALA A  55
ILE A  86
MET A 102
DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-3.6A)
0.64A 5lw1B-3f3zA:
23.1
5lw1B-3f3zA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
5 / 9 ILE A  34
GLY A  35
VAL A  42
ALA A  55
ILE A  86
DRK  A   1 (-4.2A)
DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
0.47A 5lw1B-3f3zA:
23.1
5lw1B-3f3zA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
5 / 10 GLY A  35
VAL A  42
ALA A  55
ILE A  86
LEU A 104
DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-4.4A)
0.38A 5lw1E-3f3zA:
22.8
5lw1E-3f3zA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
5 / 10 GLY A  35
VAL A  42
ALA A  55
ILE A  86
MET A 102
DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-3.6A)
0.69A 5lw1E-3f3zA:
22.8
5lw1E-3f3zA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
8 / 12 ILE A  34
GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLY A 108
GLU A 109
ILE A 168
DRK  A   1 (-4.2A)
DRK  A   1 ( 3.9A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 ( 4.2A)
0.59A 5mafA-3f3zA:
30.8
5mafA-3f3zA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 10 LEU A  15
VAL A  23
ALA A  36
MET A 117
TYR A 119
LEU A 173
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
0.70A 5n3hA-3eb0A:
25.7
5n3hA-3eb0A:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
4 / 8 ALA A  55
CYH A 105
LEU A 155
ASP A 169
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 (-4.6A)
None
0.72A 5owrA-3f3zA:
23.8
5owrA-3f3zA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
4 / 5 LEU A  15
VAL A  23
MET A 117
CYH A 184
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.8A)
DRK  A 384 ( 3.8A)
0.74A 5te0A-3eb0A:
24.1
5te0A-3eb0A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
5 / 9 LEU A  15
VAL A  23
LYS A  38
ILE A  63
ASP A 185
DRK  A 384 (-3.8A)
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 ( 4.7A)
0.93A 5yf9X-3eb0A:
29.2
5yf9X-3eb0A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum)
4 / 7 VAL A  42
LYS A  57
ILE A  86
ILE A 168
DRK  A   1 ( 4.9A)
DRK  A   1 (-4.1A)
DRK  A   1 ( 4.8A)
DRK  A   1 ( 4.2A)
0.47A 5ywmX-3f3zA:
26.1
5ywmX-3f3zA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  50
MET A  54
TYR A 119
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
DRK  A 384 (-4.4A)
0.55A 5zv2A-3eb0A:
20.5
5zv2A-3eb0A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
6 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  50
MET A  54
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
None
0.53A 5zv2B-3eb0A:
20.4
5zv2B-3eb0A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum)
7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  50
MET A  54
LEU A 173
DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 (-4.4A)
0.68A 6hd6B-3eb0A:
20.8
6hd6B-3eb0A:
13.26