SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DQV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 7 HIS A 862
GLY A 863
TYR A 896
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.45A 1dmaA-6bhvA:
6.0		 1dmaA-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 6 HIS A 862
GLY A 863
TYR A 896
ALA A 898
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.44A 1dmaB-6bhvA:
6.2		 1dmaB-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 ( 4.9A)
DQV  A1101 (-2.7A)
 0.96A 3u9hA-6bhvA:
19.2		 3u9hA-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
SER A 904
TYR A 907
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
 0.42A 3u9hA-6bhvA:
19.2		 3u9hA-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 8 HIS A 862
GLY A 863
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.68A 3u9hA-6bhvA:
19.2		 3u9hA-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS A 862
GLY A 863
ALA A 898
SER A 904
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 ( 4.1A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.90A 3u9hB-6bhvA:
19.2		 3u9hB-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 ( 4.9A)
DQV  A1101 (-2.7A)
 1.00A 3u9hB-6bhvA:
19.2		 3u9hB-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
SER A 904
TYR A 907
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
 0.46A 3u9hB-6bhvA:
19.2		 3u9hB-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 6 HIS A 862
GLY A 863
TYR A 896
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.57A 4ae1A-6bhvA:
6.5		 4ae1A-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 5 HIS A 862
GLY A 863
TYR A 896
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.51A 4ae1B-6bhvA:
6.1		 4ae1B-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 8 HIS A 862
GLY A 863
SER A 904
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.67A 4bjcA-6bhvA:
18.6		 4bjcA-6bhvA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 ( 4.9A)
DQV  A1101 (-2.7A)
 0.96A 4bjcA-6bhvA:
18.6		 4bjcA-6bhvA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
SER A 904
TYR A 907
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
 0.35A 4bjcA-6bhvA:
18.6		 4bjcA-6bhvA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		7 / 7 HIS A 862
GLY A 863
TYR A 896
ALA A 898
SER A 904
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.54A 4hyfA-6bhvA:
20.1		 4hyfA-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		7 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 ( 4.9A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.3A)
 0.82A 4hyfB-6bhvA:
20.2		 4hyfB-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		7 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
SER A 904
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.54A 4hyfB-6bhvA:
20.2		 4hyfB-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		8 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 ( 4.9A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.48A 4hyfC-6bhvA:
20.3		 4hyfC-6bhvA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		9 / 11 HIS A 862
GLY A 863
TYR A 889
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-4.2A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 ( 4.9A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.38A 4rv6A-6bhvA:
38.5		 4rv6A-6bhvA:
32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		9 / 11 HIS A 862
GLY A 863
TYR A 889
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
 DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-4.2A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 ( 4.9A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
 0.37A 4rv6B-6bhvA:
39.9		 4rv6B-6bhvA:
32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		7 / 9 HIS A 862
SER A 864
ASN A 868
ILE A 872
TYR A 896
SER A 904
TYR A 907
 DQV  A1101 (-3.6A)
DQV  A1101 (-2.9A)
DQV  A1101 (-4.2A)
DQV  A1101 (-4.5A)
DQV  A1101 (-3.5A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
 0.47A 5ha9B-6bhvA:
35.3		 5ha9B-6bhvA:
31.32