SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DQP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 TRP X  80
HIS X 111
GLU X 186
TYR X 210
SER X 211
 None
DQP  X 402 ( 4.1A)
None
NAP  X 401 ( 3.1A)
NAP  X 401 (-2.8A)
 0.26A 1s2aA-5liyX:
45.5		 1s2aA-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2INE_A_PACA317_0
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 5 TRP X  21
VAL X  48
TYR X  49
HIS X 111
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
 0.40A 2ineA-5liyX:
50.2		 2ineA-5liyX:
70.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ISF_A_PACA317_0
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 5 TRP X  21
VAL X  48
TYR X  49
HIS X 111
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
 0.46A 2isfA-5liyX:
49.9		 2isfA-5liyX:
70.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 TYR X  49
TRP X  80
HIS X 111
ASN X 161
TYR X 210
 DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
 0.28A 3r43A-5liyX:
45.0		 3r43A-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 10 TYR X  49
HIS X 111
ASN X 161
TYR X 210
PRO X 311
 DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
None
 0.38A 3r58A-5liyX:
43.9		 3r58A-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 TYR X  49
TRP X  80
HIS X 111
ASN X 161
TYR X 210
 DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
 0.31A 3r6iA-5liyX:
43.7		 3r6iA-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 9 TYR X  49
HIS X 111
ASN X 161
TYR X 210
PRO X 311
 DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
None
 0.43A 3r8gA-5liyX:
43.8		 3r8gA-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 TYR X  49
HIS X 111
ASN X 161
TYR X 210
PRO X 311
 DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
None
 0.44A 3r94A-5liyX:
43.6		 3r94A-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RX3_A_SUZA317_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 10 TRP X  21
VAL X  48
TYR X  49
HIS X 111
PHE X 123
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
DQP  X 402 (-3.7A)
 1.09A 3rx3A-5liyX:
50.4		 3rx3A-5liyX:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RX3_A_SUZA317_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		6 / 10 TRP X  21
VAL X  48
TYR X  49
HIS X 111
TRP X 220
CYH X 299
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
None
DQP  X 402 (-4.0A)
 0.70A 3rx3A-5liyX:
50.4		 3rx3A-5liyX:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 7 TRP X  21
TYR X  49
HIS X 111
PHE X 123
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
DQP  X 402 (-3.7A)
 1.08A 3s3gA-5liyX:
50.4		 3s3gA-5liyX:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 7 TRP X  21
TYR X  49
HIS X 111
TRP X 220
CYH X 299
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
None
DQP  X 402 (-4.0A)
 0.79A 3s3gA-5liyX:
50.4		 3s3gA-5liyX:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U2C_A_SUZA2001_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 9 TRP X  21
VAL X  48
TYR X  49
HIS X 111
PHE X 123
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
DQP  X 402 (-3.7A)
 1.03A 3u2cA-5liyX:
50.7		 3u2cA-5liyX:
70.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U2C_A_SUZA2001_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		6 / 9 TRP X  21
VAL X  48
TYR X  49
HIS X 111
TRP X 220
CYH X 299
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
None
DQP  X 402 (-4.0A)
 0.63A 3u2cA-5liyX:
50.7		 3u2cA-5liyX:
70.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		7 / 12 TYR X  49
TRP X  80
HIS X 111
ASN X 161
TYR X 210
SER X 211
PRO X 311
 DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
NAP  X 401 (-2.8A)
None
 0.51A 3ug8A-5liyX:
43.8		 3ug8A-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 12 TRP X  80
HIS X 111
TYR X 210
SER X 211
SER X 215
 None
DQP  X 402 ( 4.1A)
NAP  X 401 ( 3.1A)
NAP  X 401 (-2.8A)
NAP  X 401 (-2.7A)
 0.82A 3ugrA-5liyX:
44.2		 3ugrA-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 7 TYR X  49
ASN X 161
GLU X 186
PRO X 311
 DQP  X 402 ( 4.0A)
NAP  X 401 (-3.2A)
None
None
 0.61A 3ugrA-5liyX:
44.2		 3ugrA-5liyX:
46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		6 / 8 TRP X  21
VAL X  48
TRP X  80
HIS X 111
PRO X 219
TRP X 220
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
None
DQP  X 402 ( 4.1A)
DQP  X 402 (-4.5A)
None
 0.69A 3v35A-5liyX:
50.8		 3v35A-5liyX:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 8 VAL X  48
TYR X  49
TRP X  80
HIS X 111
 DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
 0.26A 4jtrA-5liyX:
45.4		 4jtrA-5liyX:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 6 VAL X  48
TYR X  49
TRP X  80
HIS X 111
 DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
 0.27A 4jtrB-5liyX:
45.5		 4jtrB-5liyX:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WEV_X_SUZX402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 10 TRP X  21
ARG X 125
TRP X 220
CYH X 299
LEU X 301
 DQP  X 402 ( 3.5A)
None
None
DQP  X 402 (-4.0A)
DQP  X 402 (-3.4A)
 1.23A 4wevX-5liyX:
55.3		 4wevX-5liyX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WEV_X_SUZX402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		6 / 10 TRP X  21
VAL X  48
PHE X 123
TRP X 220
CYH X 299
LEU X 301
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 (-3.7A)
None
DQP  X 402 (-4.0A)
DQP  X 402 (-3.4A)
 1.01A 4wevX-5liyX:
55.3		 4wevX-5liyX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WEV_X_SUZX402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		7 / 10 TRP X  21
VAL X  48
TYR X  49
HIS X 111
PHE X 123
TRP X 220
CYH X 299
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
DQP  X 402 (-3.7A)
None
DQP  X 402 (-4.0A)
 0.51A 4wevX-5liyX:
55.3		 4wevX-5liyX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		5 / 9 TYR X  49
TRP X  80
HIS X 111
ASN X 161
TYR X 210
 DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
 0.31A 4yvvA-5liyX:
45.5		 4yvvA-5liyX:
46.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens) 		4 / 5 PRO X 124
HIS X 111
TYR X 310
PHE X 312
 None
DQP  X 402 ( 4.1A)
None
DQP  X 402 (-4.9A)
 1.38A 5igjA-5liyX:
undetectable		 5igjA-5liyX:
22.48