SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DPM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 8 TYR A 213
GLY A 218
ARG A 116
THR A 243
 None
DPM  A 400 (-3.7A)
None
None
 0.93A 2f9wA-3eq1A:
undetectable
2f9wB-3eq1A:
undetectable		 2f9wA-3eq1A:
24.30
2f9wB-3eq1A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 5 GLY A 173
TRP A  18
ARG A 176
LEU A 177
 DPM  A 315 ( 4.4A)
None
DPM  A 315 ( 4.8A)
None
 1.20A 2j2pD-1gtkA:
0.0
2j2pF-1gtkA:
0.0		 2j2pD-1gtkA:
21.50
2j2pF-1gtkA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		4 / 5 GLY A 179
TRP A  24
ARG A 182
LEU A 183
 DPM  A 401 ( 4.9A)
None
DPM  A 401 (-3.6A)
None
 1.10A 2j2pD-5h6oA:
undetectable
2j2pF-5h6oA:
undetectable		 2j2pD-5h6oA:
22.26
2j2pF-5h6oA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		4 / 5 ARG A 182
ALA A 178
ASP A 109
GLU A 108
 DPM  A 401 (-3.6A)
DPM  A 401 ( 4.4A)
None
None
 1.25A 2xrzA-5h6oA:
undetectable		 2xrzA-5h6oA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 5 SER A 129
ARG A 131
GLY A 199
GLU A 102
 DPM  A 315 (-2.7A)
DPM  A 315 (-4.0A)
DPM  A 315 (-4.3A)
None
 1.21A 3k9fA-1gtkA:
1.2
3k9fB-1gtkA:
1.2
3k9fC-1gtkA:
undetectable		 3k9fA-1gtkA:
21.40
3k9fB-1gtkA:
21.40
3k9fC-1gtkA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 VAL A 152
ARG A 155
VAL A 109
LEU A 174
GLY A 126
 None
DPM  A 315 (-2.7A)
None
None
None
 1.08A 3rr3B-1gtkA:
0.0		 3rr3B-1gtkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 VAL A 152
ARG A 155
VAL A 109
LEU A 174
GLY A 126
 None
DPM  A 315 (-2.7A)
None
None
None
 1.08A 3rr3C-1gtkA:
0.0		 3rr3C-1gtkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 12 VAL A 152
ARG A 155
VAL A 109
LEU A 174
GLY A 126
 None
DPM  A 315 (-2.7A)
None
None
None
 1.08A 3rr3D-1gtkA:
0.0		 3rr3D-1gtkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 10 VAL A 152
ARG A 155
VAL A 109
LEU A 174
GLY A 126
 None
DPM  A 315 (-2.7A)
None
None
None
 1.07A 4ph9A-1gtkA:
0.0		 4ph9A-1gtkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		5 / 10 VAL A 152
ARG A 155
VAL A 109
LEU A 174
GLY A 126
 None
DPM  A 315 (-2.7A)
None
None
None
 1.08A 4ph9B-1gtkA:
0.0		 4ph9B-1gtkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 5 ARG A 131
GLY A 199
GLU A 102
SER A 129
 DPM  A 315 (-4.0A)
DPM  A 315 (-4.3A)
None
DPM  A 315 (-2.7A)
 1.18A 4z3oA-1gtkA:
undetectable
4z3oB-1gtkA:
undetectable		 4z3oA-1gtkA:
19.67
4z3oB-1gtkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 5 SER A 129
GLY A 199
GLU A 102
ARG A 131
 DPM  A 315 (-2.7A)
DPM  A 315 (-4.3A)
None
DPM  A 315 (-4.0A)
 1.10A 5cdqR-1gtkA:
0.1
5cdqS-1gtkA:
undetectable
5cdqT-1gtkA:
0.7		 5cdqR-1gtkA:
21.56
5cdqS-1gtkA:
20.49
5cdqT-1gtkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 6 ARG A 156
PHE A 158
ILE A 187
THR A 145
 None
None
None
DPM  A 400 ( 4.8A)
 1.02A 5vceA-3eq1A:
undetectable		 5vceA-3eq1A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 8 GLY A 199
ARG A 132
GLN A 135
ASP A 106
 DPM  A 315 (-4.3A)
DPM  A 315 (-2.7A)
None
None
 0.87A 5vlmA-1gtkA:
undetectable		 5vlmA-1gtkA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 8 GLY A 218
ARG A 150
GLN A 153
ASP A 121
 DPM  A 400 (-3.7A)
DPM  A 400 (-2.8A)
None
None
 0.83A 5vlmA-3eq1A:
undetectable		 5vlmA-3eq1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		4 / 8 GLY A 205
ARG A 138
GLN A 141
ASP A 112
 DPM  A 401 (-3.7A)
DPM  A 401 (-3.1A)
None
None
 0.83A 5vlmA-5h6oA:
undetectable		 5vlmA-5h6oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 1gtk PORPHOBILINOGEN
DEAMINASE
(Escherichia
coli) 		4 / 8 GLY A 199
ARG A 132
GLN A 135
ASP A 106
 DPM  A 315 (-4.3A)
DPM  A 315 (-2.7A)
None
None
 0.84A 5vlmB-1gtkA:
undetectable		 5vlmB-1gtkA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		4 / 8 GLY A 218
ARG A 150
GLN A 153
ASP A 121
 DPM  A 400 (-3.7A)
DPM  A 400 (-2.8A)
None
None
 0.83A 5vlmB-3eq1A:
undetectable		 5vlmB-3eq1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 5h6o PORPHOBILINOGEN
DEAMINASE
(Vibrio
cholerae) 		4 / 8 GLY A 205
ARG A 138
GLN A 141
ASP A 112
 DPM  A 401 (-3.7A)
DPM  A 401 (-3.1A)
None
None
 0.77A 5vlmB-5h6oA:
undetectable		 5vlmB-5h6oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens) 		5 / 9 VAL A 267
HIS A 268
ILE A 350
LEU A 351
ARG A 149
 None
SO4  A 363 (-4.1A)
None
None
DPM  A 400 (-3.6A)
 1.33A 6c2mC-3eq1A:
undetectable		 6c2mC-3eq1A:
12.39