SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DPF'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
4 / 8 GLY A 136
GLU A 217
SER A 218
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
DPF  A 601 (-4.2A)
0.75A 1ax9A-4fnmA:
38.9
1ax9A-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
6 / 12 GLY A 135
GLY A 136
GLY A 137
SER A 218
PHE A 354
HIS A 471
DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
1.12A 1dx6A-4fnmA:
39.3
1dx6A-4fnmA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
7 / 12 GLY A 135
GLY A 136
GLY A 137
SER A 218
TRP A 251
PHE A 309
HIS A 471
DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
DPF  A 601 ( 3.7A)
None
DPF  A 601 (-4.2A)
0.69A 1dx6A-4fnmA:
39.3
1dx6A-4fnmA:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 12 GLU A 142
LEU A 475
TYR A 457
GLY A 136
GLY A 141
None
None
DPF  A 601 (-3.2A)
DPF  A 601 (-3.4A)
None
1.28A 1httB-4fnmA:
undetectable
1httB-4fnmA:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 12 GLY A 136
GLU A 217
SER A 218
PHE A 309
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
0.73A 1maaA-4fnmA:
38.2
1maaA-4fnmA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 12 GLY A 136
TYR A 132
SER A 218
PHE A 309
HIS A 471
DPF  A 601 (-3.4A)
None
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
1.21A 1maaC-4fnmA:
38.2
1maaC-4fnmA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 12 GLY A 136
TYR A 132
SER A 218
PHE A 354
HIS A 471
DPF  A 601 (-3.4A)
None
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
1.21A 1maaC-4fnmA:
38.2
1maaC-4fnmA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 12 GLY A 136
TYR A 148
SER A 218
PHE A 309
HIS A 471
DPF  A 601 (-3.4A)
None
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
0.83A 1maaC-4fnmA:
38.2
1maaC-4fnmA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
4 / 8 GLY A 136
GLU A 217
SER A 218
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
DPF  A 601 (-4.2A)
0.38A 1maaD-4fnmA:
38.2
1maaD-4fnmA:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
4 / 8 GLY A 137
GLU A 217
SER A 218
HIS A 471
DPF  A 601 (-3.7A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
DPF  A 601 (-4.2A)
0.80A 1maaD-4fnmA:
38.2
1maaD-4fnmA:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 12 GLY A 136
GLY A 137
SER A 218
PHE A 421
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
0.56A 1mx1D-4fnmA:
37.5
1mx1D-4fnmA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 12 GLY A 136
GLY A 137
SER A 218
PHE A 421
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
0.48A 1mx1F-4fnmA:
37.3
1mx1F-4fnmA:
29.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
7 / 12 GLY A 135
GLY A 136
GLY A 137
GLU A 217
SER A 218
PHE A 309
HIS A 471
DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
0.52A 1qtiA-4fnmA:
38.6
1qtiA-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
6 / 12 GLY A 135
GLY A 136
GLY A 137
SER A 218
PHE A 354
HIS A 471
DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
1.08A 1qtiA-4fnmA:
38.6
1qtiA-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 12 GLY A 135
GLY A 136
GLY A 137
PHE A 309
PHE A 354
DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
None
None
0.72A 1w6rA-4fnmA:
39.2
1w6rA-4fnmA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
6 / 12 GLY A 135
GLY A 136
GLY A 137
SER A 218
PHE A 309
HIS A 471
DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
0.61A 1w6rA-4fnmA:
39.2
1w6rA-4fnmA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
6 / 11 GLY A 136
GLY A 137
GLU A 217
SER A 218
PHE A 309
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
0.55A 1w76A-4fnmA:
38.5
1w76A-4fnmA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
6 / 10 GLY A 135
GLY A 136
GLU A 217
SER A 218
PHE A 309
HIS A 471
DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
0.52A 1w76B-4fnmA:
38.5
1w76B-4fnmA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 10 GLY A 135
GLY A 136
SER A 218
PHE A 354
HIS A 471
DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
1.01A 1w76B-4fnmA:
38.5
1w76B-4fnmA:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 9 GLY A 135
GLY A 136
SER A 218
ALA A 219
HIS A 471
DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-1.5A)
DPF  A 601 (-3.3A)
DPF  A 601 (-4.2A)
0.87A 2aceA-4fnmA:
10.7
2aceA-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
6 / 9 GLY A 136
GLY A 137
ALA A 219
TRP A 251
PHE A 309
PHE A   3
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-3.3A)
DPF  A 601 ( 3.7A)
None
None
1.37A 2aceA-4fnmA:
10.7
2aceA-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
7 / 9 GLY A 136
GLY A 137
SER A 218
ALA A 219
TRP A 251
PHE A 309
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
DPF  A 601 (-3.3A)
DPF  A 601 ( 3.7A)
None
DPF  A 601 (-4.2A)
0.72A 2aceA-4fnmA:
10.7
2aceA-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
4 / 7 GLY A 136
GLU A 217
SER A 218
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
DPF  A 601 (-4.2A)
0.82A 2ackA-4fnmA:
39.0
2ackA-4fnmA:
30.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
6 / 8 GLY A 136
GLY A 137
ALA A 219
TRP A 251
PHE A 309
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-3.3A)
DPF  A 601 ( 3.7A)
None
DPF  A 601 (-4.2A)
0.78A 2ha4A-4fnmA:
38.3
2ha4A-4fnmA:
30.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
6 / 7 GLY A 136
GLY A 137
ALA A 219
TRP A 251
PHE A 309
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-3.3A)
DPF  A 601 ( 3.7A)
None
DPF  A 601 (-4.2A)
0.79A 2ha4B-4fnmA:
38.7
2ha4B-4fnmA:
30.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
3 / 3 TYR A 165
GLU A 217
ASP A 473
None
DPF  A 601 ( 4.2A)
None
0.77A 3bxoA-4fnmA:
undetectable
3bxoA-4fnmA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
3 / 3 TYR A 165
GLU A 217
ASP A 473
None
DPF  A 601 ( 4.2A)
None
0.79A 3bxoB-4fnmA:
undetectable
3bxoB-4fnmA:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_A_BEZA999_0
(CHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
6 / 7 GLY A 136
GLY A 137
SER A 218
TRP A 251
PHE A 421
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
DPF  A 601 ( 3.7A)
None
DPF  A 601 (-4.2A)
0.66A 3o9mA-4fnmA:
38.7
3o9mA-4fnmA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_B_BEZB999_0
(CHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 6 GLY A 136
GLY A 137
SER A 218
TRP A 251
HIS A 471
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
DPF  A 601 ( 3.7A)
DPF  A 601 (-4.2A)
0.43A 3o9mB-4fnmA:
38.9
3o9mB-4fnmA:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
6 / 12 GLY A 135
GLY A 136
GLY A 137
SER A 218
PHE A 309
HIS A 471
DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
0.54A 4ey6A-4fnmA:
38.7
4ey6A-4fnmA:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
6 / 12 GLY A 135
GLY A 136
GLY A 137
GLU A 217
PHE A 354
HIS A 471
DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 ( 4.2A)
None
DPF  A 601 (-4.2A)
1.12A 4ey6B-4fnmA:
38.3
4ey6B-4fnmA:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
7 / 12 GLY A 135
GLY A 136
GLY A 137
GLU A 217
SER A 218
PHE A 309
HIS A 471
DPF  A 601 ( 3.8A)
DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 ( 4.2A)
DPF  A 601 (-1.5A)
None
DPF  A 601 (-4.2A)
0.52A 4ey6B-4fnmA:
38.3
4ey6B-4fnmA:
30.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 12 MET A 227
ALA A 221
PHE A 138
HIS A 471
GLY A 245
None
None
None
DPF  A 601 (-4.2A)
None
1.02A 4ls7A-4fnmA:
undetectable
4ls7B-4fnmA:
undetectable
4ls7A-4fnmA:
21.33
4ls7B-4fnmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 12 MET A 227
ILE A 133
ALA A 221
PHE A 138
HIS A 471
None
None
None
None
DPF  A 601 (-4.2A)
1.07A 4ls7A-4fnmA:
undetectable
4ls7B-4fnmA:
undetectable
4ls7A-4fnmA:
21.33
4ls7B-4fnmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
4 / 5 GLY A 135
TYR A 226
SER A 223
GLU A 217
DPF  A 601 ( 3.8A)
None
None
DPF  A 601 ( 4.2A)
1.18A 4xueA-4fnmA:
2.2
4xueA-4fnmA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia
cuprina)
5 / 12 ALA A 194
GLN A 164
GLY A 220
ALA A 219
LEU A 167
None
None
None
DPF  A 601 (-3.3A)
None
1.07A 5xxiA-4fnmA:
undetectable
5xxiA-4fnmA:
20.50