SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DOW'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		4 / 8 GLY A 104
THR A 105
ALA A 106
ALA A 107
 DOW  A 501 (-3.3A)
DOW  A 501 (-3.6A)
None
None
 0.58A 2ej3A-6cblA:
undetectable		 2ej3A-6cblA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cbl NEAMINE TRANSAMINASE
NEON
(Streptomyces
fradiae) 		5 / 12 ASP A 204
VAL A 206
VAL A 228
SER A 103
SER A 240
 DOW  A 501 (-2.7A)
DOW  A 501 (-4.0A)
None
DOW  A 501 ( 4.0A)
None
 1.33A 6h7mB-6cblA:
undetectable		 6h7mB-6cblA:
25.00