SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DNO'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DMA_B_NCAB700_0 (EXOTOXIN A)	3bdk	D-MANNONATE DEHYDRATASE (Streptococcus suis)	4 / 6	GLY A 29 ALA A 51 TYR A 28 GLU A 84	None None None DNO A 387 ( 4.8A)	1.01A	1dmaB-3bdkA: undetectable	1dmaB-3bdkA: 19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJT_A_SAMA501_1 (N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE)	3bdk	D-MANNONATE DEHYDRATASE (Streptococcus suis)	3 / 3	ARG A 242 ASP A 221 ASP A 130	None None DNO A 387 (-3.4A)	0.73A	2ejtA-3bdkA: 0.8	2ejtA-3bdkA: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XIN_C_SORC397_0 (D-XYLOSE ISOMERASE)	3bdk	D-MANNONATE DEHYDRATASE (Streptococcus suis)	5 / 12	VAL A 49 GLU A 84 HIS A 219 ASP A 222 ASP A 330	None DNO A 387 ( 4.8A) MN A 388 (-3.6A) DNO A 387 (-3.9A) MN A 388 (-2.7A)	1.35A	2xinC-3bdkA: 22.0	2xinC-3bdkA: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XYT_H_TC9H1206_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3bdk	D-MANNONATE DEHYDRATASE (Streptococcus suis)	4 / 7	TYR A 225 ILE A 227 ASP A 222 SER A 263	None None DNO A 387 (-3.9A) None	1.20A	2xytI-3bdkA: undetectable	2xytI-3bdkA: 21.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DMA_B_NCAB700_0","EXOTOXIN A","3bdk","D-MANNONATE DEHYDRATASE","Streptococcus suis",4,"GLY A  29;ALA A  51;TYR A  28;GLU A  84","None;None;None;DNO A 387 ( 4.8A)","1.01A","1dmaB-3bdkA:undetectable",null],["2EJT_A_SAMA501_1","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","3bdk","D-MANNONATE DEHYDRATASE","Streptococcus suis",3,"ARG A 242;ASP A 221;ASP A 130","None;None;DNO A 387 (-3.4A)","0.73A","2ejtA-3bdkA:0.8","1dmaB-3bdkA:19.43"],["2XIN_C_SORC397_0","D-XYLOSE ISOMERASE","3bdk","D-MANNONATE DEHYDRATASE","Streptococcus suis",5,"VAL A  49;GLU A  84;HIS A 219;ASP A 222;ASP A 330","None;DNO A 387 ( 4.8A); MN A 388 (-3.6A);DNO A 387 (-3.9A); MN A 388 (-2.7A)","1.35A","2xinC-3bdkA:22.0","2ejtA-3bdkA:22.97"],["2XYT_H_TC9H1206_2","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","3bdk","D-MANNONATE DEHYDRATASE","Streptococcus suis",4,"TYR A 225;ILE A 227;ASP A 222;SER A 263","None;None;DNO A 387 (-3.9A);None","1.20A","2xytI-3bdkA:undetectable","2xinC-3bdkA:21.10"]]