SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DND'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 ARG A 160
GLY A  17
ILE A 104
GLY A 106
THR A  10
 None
DND  A 601 ( 4.3A)
None
DND  A 601 (-3.2A)
DND  A 601 (-3.1A)
 0.95A 1c6zA-1kaqA:
undetectable		 1c6zA-1kaqA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 8 PHE A  70
ILE A  34
PHE A   7
PHE A  11
HIS A  18
 None
None
DND  A 601 (-4.2A)
None
DND  A 601 (-4.0A)
 1.25A 1fslA-1kaqA:
undetectable		 1fslA-1kaqA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 GLY A   8
HIS A  15
HIS A  18
GLY A 106
ASP A 108
 DND  A 998 (-3.2A)
None
DND  A 998 ( 4.6A)
DND  A 998 (-3.1A)
DND  A 998 (-3.0A)
 0.84A 1jzsA-2h29A:
undetectable		 1jzsA-2h29A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 GLY A   8
HIS A  18
GLY A 106
ASP A 108
GLN A 109
 DND  A 998 (-3.2A)
DND  A 998 ( 4.6A)
DND  A 998 (-3.1A)
DND  A 998 (-3.0A)
DND  A 998 (-3.4A)
 0.90A 1jzsA-2h29A:
undetectable		 1jzsA-2h29A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 ALA A  17
HIS A  18
VAL A  21
 DND  A 998 (-3.1A)
DND  A 998 ( 4.6A)
None
 0.34A 1lqtB-2h29A:
undetectable		 1lqtB-2h29A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 ALA A  19
HIS A  20
VAL A  23
 DND  A 301 (-3.1A)
DND  A 301 (-4.2A)
None
 0.31A 1lqtB-5lltA:
2.8		 1lqtB-5lltA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		3 / 3 ALA A  17
HIS A  18
VAL A  21
 DND  A 998 (-3.1A)
DND  A 998 ( 4.6A)
None
 0.35A 1lquB-2h29A:
undetectable		 1lquB-2h29A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 ALA A  19
HIS A  20
VAL A  23
 DND  A 301 (-3.1A)
DND  A 301 (-4.2A)
None
 0.32A 1lquB-5lltA:
2.7		 1lquB-5lltA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		3 / 3 THR A  95
LEU A  99
LEU A 106
 DND  A 301 (-3.9A)
None
None
 0.52A 1mz9C-1kqoA:
undetectable		 1mz9C-1kqoA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 11 HIS A  15
HIS A  18
GLY A 106
ASP A 108
VAL A 152
 None
DND  A 998 ( 4.6A)
DND  A 998 (-3.1A)
DND  A 998 (-3.0A)
None
 0.68A 1pg2A-2h29A:
5.7		 1pg2A-2h29A:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5j8d OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Enterobacter
cloacae) 		6 / 8 TYR A  68
PHE A  70
ASN A  71
LYS A  74
GLU A 165
GLY A 166
 DND  A 302 (-4.8A)
DND  A 302 ( 4.7A)
FMN  A 301 ( 3.1A)
DND  A 302 ( 2.8A)
FMN  A 301 (-3.6A)
FMN  A 301 (-3.5A)
 0.70A 1ykiA-5j8dA:
34.1
1ykiB-5j8dA:
34.2		 1ykiA-5j8dA:
87.96
1ykiB-5j8dA:
87.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5j8d OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Enterobacter
cloacae) 		6 / 8 TYR A  68
PHE A  70
ASN A  71
LYS A  74
GLU A 165
GLY A 166
 DND  A 302 (-4.8A)
DND  A 302 ( 4.7A)
FMN  A 301 ( 3.1A)
DND  A 302 ( 2.8A)
FMN  A 301 (-3.6A)
FMN  A 301 (-3.5A)
 0.73A 1ykiA-5j8dA:
34.1
1ykiB-5j8dA:
34.2		 1ykiA-5j8dA:
87.96
1ykiB-5j8dA:
87.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5j8d OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Enterobacter
cloacae) 		6 / 8 TYR A  68
PHE A  70
ASN A  71
LYS A  74
GLU A 165
GLY A 166
 DND  A 302 (-4.8A)
DND  A 302 ( 4.7A)
FMN  A 301 ( 3.1A)
DND  A 302 ( 2.8A)
FMN  A 301 (-3.6A)
FMN  A 301 (-3.5A)
 0.71A 1ykiC-5j8dA:
34.1
1ykiD-5j8dA:
33.8		 1ykiC-5j8dA:
87.96
1ykiD-5j8dA:
87.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5j8d OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE
(Enterobacter
cloacae) 		6 / 8 TYR A  68
PHE A  70
ASN A  71
LYS A  74
GLU A 165
GLY A 166
 DND  A 302 (-4.8A)
DND  A 302 ( 4.7A)
FMN  A 301 ( 3.1A)
DND  A 302 ( 2.8A)
FMN  A 301 (-3.6A)
FMN  A 301 (-3.5A)
 0.69A 1ykiC-5j8dA:
34.1
1ykiD-5j8dA:
33.8		 1ykiC-5j8dA:
87.96
1ykiD-5j8dA:
87.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 6 SER A 102
ALA A 101
THR A 104
ASN A 108
 None
None
DND  A 301 (-4.0A)
DND  A 301 (-3.2A)
 1.04A 1yvpB-1xngA:
undetectable		 1yvpB-1xngA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 PHE A  70
PHE A  36
PHE A  11
HIS A  18
 None
None
None
DND  A 601 (-4.0A)
 1.11A 2lh6A-1kaqA:
0.0		 2lh6A-1kaqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 4 PRO A  65
ASP A 185
ASP A 192
ASP A  70
 None
None
DND  A 301 ( 4.2A)
None
 1.48A 2nyuA-1xngA:
2.5		 2nyuA-1xngA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 125
VAL A 126
TRP A 119
SER A 168
SER A 169
 None
None
DND  A 301 (-3.6A)
DND  A 301 ( 4.6A)
None
 1.27A 2y00A-5lltA:
undetectable		 2y00A-5lltA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 125
VAL A 126
TRP A 119
SER A 168
SER A 169
 None
None
DND  A 301 (-3.6A)
DND  A 301 ( 4.6A)
None
 1.30A 2y00B-5lltA:
undetectable		 2y00B-5lltA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 125
VAL A 126
TRP A 119
SER A 168
SER A 169
 None
None
DND  A 301 (-3.6A)
DND  A 301 ( 4.6A)
None
 1.31A 2y01B-5lltA:
undetectable		 2y01B-5lltA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 GLY A   8
ILE A   4
LEU A  31
LEU A  26
VAL A  25
 DND  A 601 (-3.9A)
None
None
None
None
 0.88A 3adxB-1kaqA:
0.0		 3adxB-1kaqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 VAL A  75
GLN A  40
PHE A   7
ARG A  95
 None
None
DND  A 601 (-4.2A)
None
 1.33A 3bjwE-1kaqA:
0.0		 3bjwE-1kaqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		4 / 5 ILE A 226
SER A 223
PRO A  19
PHE A  17
 None
DND  A 301 ( 4.7A)
None
DND  A 301 (-4.6A)
 0.98A 3bjwC-1kqoA:
undetectable		 3bjwC-1kqoA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		3 / 3 LEU A  27
HIS A  24
MET A  23
 DND  A 301 (-4.0A)
DND  A 301 ( 4.7A)
DND  A 301 (-3.2A)
 0.94A 3thrD-1kqoA:
undetectable		 3thrD-1kqoA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 9 LEU A   6
ILE A 145
ILE A 147
PHE A 103
VAL A 104
 None
None
None
DND  A 998 (-4.9A)
None
 1.25A 3tmzA-2h29A:
undetectable		 3tmzA-2h29A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 12 HIS A  18
GLY A 106
PRO A  43
HIS A  44
GLY A   9
 DND  A 601 (-4.0A)
DND  A 601 (-3.2A)
DND  A 601 (-4.5A)
DND  A 601 (-3.3A)
DND  A 601 (-2.8A)
 1.09A 4bz6C-1kaqA:
undetectable		 4bz6C-1kaqA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 4 ILE A 166
ASN A 164
ILE A 134
VAL A  23
 None
None
DND  A 301 ( 4.5A)
None
 0.88A 4uy87-5lltA:
undetectable		 4uy87-5lltA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 10 THR A  88
ILE A  89
LEU A 101
PHE A  92
GLY A   8
 None
None
None
None
DND  A 998 (-3.2A)
 0.97A 5mxbA-2h29A:
undetectable		 5mxbA-2h29A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 12 PHE A  11
ILE A  60
ILE A  64
ILE A   4
GLU A  76
 None
None
None
None
DND  A 998 ( 4.6A)
 1.13A 5vceA-2h29A:
undetectable		 5vceA-2h29A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		5 / 12 GLY A  35
ASP A 148
LEU A 149
CYH A 151
ASP A  37
 ATP  A 303 (-3.2A)
DND  A 301 (-3.2A)
None
None
ATP  A 303 (-3.9A)
 1.18A 5yniA-1xngA:
undetectable		 5yniA-1xngA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		5 / 12 GLY A  35
ASP A 148
LEU A 149
CYH A 151
ASP A  37
 ATP  A 303 (-3.2A)
DND  A 301 (-3.2A)
None
None
ATP  A 303 (-3.9A)
 1.17A 5ynmA-1xngA:
undetectable		 5ynmA-1xngA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 12 PHE A  13
GLY A 107
ASN A 129
ILE A 133
LEU A 108
 DND  A 301 (-4.4A)
None
None
None
DND  A 301 (-4.6A)
 1.17A 6b3bA-5lltA:
2.3		 6b3bA-5lltA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		5 / 10 LEU A 159
THR A 187
CYH A 155
ALA A 193
LEU A 183
 DND  A 301 (-4.1A)
None
DND  A 301 (-4.7A)
None
None
 0.98A 6czmA-1kqoA:
0.2
6czmC-1kqoA:
undetectable		 6czmA-1kqoA:
22.37
6czmC-1kqoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  11
VAL A  80
THR A  74
ALA A  73
PHE A  17
 None
None
None
None
DND  A 301 (-4.6A)
 1.46A 6drxA-1kqoA:
undetectable		 6drxA-1kqoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 GLY A   9
THR A  10
HIS A  18
SER A 155
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
DND  A 601 (-4.0A)
None
 0.23A 6jmjA-1kaqA:
15.9		 6jmjA-1kaqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 5 GLY A   9
THR A  10
SER A 155
SER A 156
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
None
None
 0.96A 6jmjA-1kaqA:
15.9		 6jmjA-1kaqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		4 / 5 GLY A  15
HIS A  24
SER A 222
SER A 223
 DND  A 301 (-3.4A)
DND  A 301 ( 4.7A)
None
DND  A 301 ( 4.7A)
 0.37A 6jmjA-1kqoA:
14.2		 6jmjA-1kqoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 5 GLY A   9
HIS A  18
SER A 155
SER A 156
 DND  A 998 (-3.2A)
DND  A 998 ( 4.6A)
None
None
 0.23A 6jmjA-2h29A:
15.4		 6jmjA-2h29A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 5 GLY A  11
HIS A  20
SER A 167
SER A 168
 DND  A 301 (-3.6A)
DND  A 301 (-4.2A)
None
DND  A 301 ( 4.6A)
 0.15A 6jmjA-5lltA:
16.0		 6jmjA-5lltA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		5 / 7 GLY A   9
THR A  10
PHE A  11
HIS A  18
SER A 155
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
None
DND  A 601 (-4.0A)
None
 0.34A 6jnhA-1kaqA:
16.0		 6jnhA-1kaqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		5 / 7 GLY A  15
PHE A  17
HIS A  24
SER A 222
SER A 223
 DND  A 301 (-3.4A)
DND  A 301 (-4.6A)
DND  A 301 ( 4.7A)
None
DND  A 301 ( 4.7A)
 0.38A 6jnhA-1kqoA:
14.2		 6jnhA-1kqoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		5 / 7 GLY A   9
PHE A  11
HIS A  18
SER A 155
SER A 156
 DND  A 998 (-3.2A)
None
DND  A 998 ( 4.6A)
None
None
 0.24A 6jnhA-2h29A:
15.4		 6jnhA-2h29A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		5 / 7 GLY A  11
PHE A  13
HIS A  20
SER A 167
SER A 168
 DND  A 301 (-3.6A)
DND  A 301 (-4.4A)
DND  A 301 (-4.2A)
None
DND  A 301 ( 4.6A)
 0.23A 6jnhA-5lltA:
16.1		 6jnhA-5lltA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 6 GLY A   9
THR A  10
HIS A  18
SER A 155
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
DND  A 601 (-4.0A)
None
 0.27A 6jogA-1kaqA:
15.9		 6jogA-1kaqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Bacillus
subtilis) 		4 / 6 GLY A   9
THR A  10
SER A 155
SER A 156
 DND  A 601 (-2.8A)
DND  A 601 (-3.1A)
None
None
 0.98A 6jogA-1kaqA:
15.9		 6jogA-1kaqA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		4 / 6 GLY A  15
HIS A  24
SER A 222
SER A 223
 DND  A 301 (-3.4A)
DND  A 301 ( 4.7A)
None
DND  A 301 ( 4.7A)
 0.42A 6jogA-1kqoA:
14.2		 6jogA-1kqoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2h29 PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Staphylococcus
aureus) 		4 / 6 GLY A   9
HIS A  18
SER A 155
SER A 156
 DND  A 998 (-3.2A)
DND  A 998 ( 4.6A)
None
None
 0.20A 6jogA-2h29A:
15.4		 6jogA-2h29A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 6 GLY A  11
HIS A  20
SER A 167
SER A 168
 DND  A 301 (-3.6A)
DND  A 301 (-4.2A)
None
DND  A 301 ( 4.6A)
 0.17A 6jogA-5lltA:
16.1		 6jogA-5lltA:
23.04