SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DMU'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
4mzv EPITHELIAL CELL
ADHESION MOLECULE

(Homo
sapiens)
5 / 11 LEU A 166
LYS A 168
TYR A 186
TYR A 157
LEU A 233
None
None
None
None
DMU  A 301 ( 4.6A)
1.48A 1klmA-4mzvA:
2.7
1klmA-4mzvA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)
4mzv EPITHELIAL CELL
ADHESION MOLECULE

(Homo
sapiens)
4 / 6 GLU A 223
ASP A 219
PHE A 226
ARG A 173
None
None
None
DMU  A 301 (-4.0A)
1.46A 2a3bB-4mzvA:
undetectable
2a3bB-4mzvA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
3tij NUPC FAMILY PROTEIN
(Vibrio
cholerae)
5 / 12 LEU A 406
LEU A 403
ALA A 400
ILE A 399
ALA A 367
None
None
None
DMU  A 424 ( 4.7A)
None
1.24A 2bxpA-3tijA:
undetectable
2bxpA-3tijA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus)
4 / 7 SER A  21
LEU A 169
HIS A 180
THR A 144
None
None
DMU  A 501 ( 4.6A)
DMU  A 501 (-3.9A)
1.14A 2f78A-6d0nA:
undetectable
2f78A-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
3tij NUPC FAMILY PROTEIN
(Vibrio
cholerae)
5 / 10 LEU A 379
GLY A 377
LEU A 376
LEU A 375
ILE A 372
None
None
None
None
DMU  A 420 (-3.9A)
1.02A 2f8dA-3tijA:
undetectable
2f8dA-3tijA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)
3tij NUPC FAMILY PROTEIN
(Vibrio
cholerae)
4 / 5 PHE A  97
PHE A 270
PHE A 333
ILE A 277
None
DMU  A 422 ( 4.1A)
URI  A 419 (-4.9A)
None
1.37A 2v0mD-3tijA:
undetectable
2v0mD-3tijA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)
3tij NUPC FAMILY PROTEIN
(Vibrio
cholerae)
4 / 8 LEU A 376
ARG A 387
GLY A 388
ALA A 391
None
None
None
DMU  A 420 (-4.9A)
0.89A 2xfsA-3tijA:
undetectable
2xfsA-3tijA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)
3tij NUPC FAMILY PROTEIN
(Vibrio
cholerae)
4 / 8 LEU A 376
ARG A 387
GLY A 388
ALA A 391
None
None
None
DMU  A 420 (-4.9A)
0.90A 2xh9A-3tijA:
undetectable
2xh9A-3tijA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus)
4 / 6 ILE A 364
ILE A 389
LEU A 376
PHE A 379
None
DMU  A 502 ( 4.7A)
None
None
1.13A 3adsA-6d0nA:
undetectable
3adsA-6d0nA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)
5da0 SULPHATE TRANSPORTER
(Deinococcus
geothermalis)
5 / 12 ILE A 290
GLN A 287
PRO A  37
ILE A 139
VAL A 335
None
None
None
None
DMU  A 601 (-4.7A)
1.23A 3iw1A-5da0A:
undetectable
3iw1A-5da0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)
4a01 PROTON
PYROPHOSPHATASE

(Vigna
radiata)
5 / 12 GLU A 747
LEU A 232
ILE A 107
PHE A  99
PHE A 240
None
None
None
DMU  A1776 (-4.5A)
None
1.39A 3ko0G-4a01A:
undetectable
3ko0H-4a01A:
1.2
3ko0I-4a01A:
1.8
3ko0J-4a01A:
1.7
3ko0G-4a01A:
8.76
3ko0H-4a01A:
8.76
3ko0I-4a01A:
8.76
3ko0J-4a01A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
4a01 PROTON
PYROPHOSPHATASE

(Vigna
radiata)
5 / 12 ILE A 643
GLY A 646
ALA A 647
LEU A 651
LEU A 654
DMU  A1776 ( 4.9A)
None
DMU  A1776 ( 4.1A)
DMU  A1775 ( 4.9A)
None
0.73A 3n8yB-4a01A:
undetectable
3n8yB-4a01A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
4a01 PROTON
PYROPHOSPHATASE

(Vigna
radiata)
5 / 12 LEU A 239
ILE A 643
GLY A 646
ALA A 647
LEU A 651
None
DMU  A1776 ( 4.9A)
None
DMU  A1776 ( 4.1A)
DMU  A1775 ( 4.9A)
0.94A 3n8zB-4a01A:
0.5
3n8zB-4a01A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)
4mzv EPITHELIAL CELL
ADHESION MOLECULE

(Homo
sapiens)
3 / 3 TYR A 174
ASP A 232
ASP A 219
DMU  A 301 (-4.7A)
DMU  A 301 (-3.5A)
None
0.67A 3r24A-4mzvA:
undetectable
3r24A-4mzvA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
3tij NUPC FAMILY PROTEIN
(Vibrio
cholerae)
5 / 12 GLY A 137
LEU A 128
GLY A 131
ALA A 146
ALA A 147
None
DMU  A 425 ( 4.5A)
DMU  A 425 ( 4.3A)
None
None
1.02A 3sufA-3tijA:
undetectable
3sufA-3tijA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
5da0 SULPHATE TRANSPORTER
(Deinococcus
geothermalis)
5 / 12 GLY A 267
ARG A 118
LEU A 240
GLY A 238
ALA A 117
None
None
DMU  A 601 (-3.9A)
None
None
1.00A 3sufA-5da0A:
undetectable
3sufA-5da0A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)
5da0 SULPHATE TRANSPORTER
(Deinococcus
geothermalis)
5 / 9 PHE A  42
ALA A 142
ALA A 336
THR A 339
LEU A  83
None
None
None
DMU  A 601 (-3.4A)
None
1.02A 3t3sA-5da0A:
undetectable
3t3sA-5da0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)
2bbh DIVALENT CATION
TRANSPORT-RELATED
PROTEIN

(Thermotoga
maritima)
5 / 9 ILE A 225
VAL A 146
PHE A 113
LEU A 177
ASP A 179
None
None
DMU  A 402 (-4.3A)
DMU  A 402 ( 4.7A)
DMU  A 404 (-4.6A)
1.26A 3ti1A-2bbhA:
undetectable
3ti1A-2bbhA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)
4a01 PROTON
PYROPHOSPHATASE

(Vigna
radiata)
5 / 12 ARG A 562
PHE A 751
PHE A 754
HIS A 758
GLU A 225
None
None
None
DMU  A1778 (-3.9A)
None
1.24A 4bvaB-4a01A:
undetectable
4bvaB-4a01A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)
4a01 PROTON
PYROPHOSPHATASE

(Vigna
radiata)
5 / 11 LEU A 743
VAL A 649
PHE A  99
SER A 236
PHE A 103
None
None
DMU  A1776 (-4.5A)
None
None
1.17A 4evrA-4a01A:
undetectable
4evrA-4a01A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus)
4 / 6 LEU A 145
LYS A 140
LEU A  17
GLU A  13
None
None
DMU  A 501 ( 4.8A)
None
1.09A 4f3tA-6d0nA:
undetectable
4f3tA-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides)
5 / 12 TRP A 439
LEU A  34
ILE A 515
ALA A 428
VAL A 111
None
DMU  A   7 (-4.3A)
DMU  A   7 ( 4.4A)
None
HEA  A   1 (-4.5A)
1.05A 4hfpD-3omnA:
undetectable
4hfpD-3omnA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
5eik UNCHARACTERIZED
PROTEIN Y57A10A.28

(Caenorhabditis
elegans)
5 / 10 VAL A  22
TYR A  21
VAL A 226
ILE A 230
LEU A 129
None
DMU  A 310 ( 2.9A)
None
None
None
1.49A 4jtqA-5eikA:
undetectable
4jtqA-5eikA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_B_FLPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
5eik UNCHARACTERIZED
PROTEIN Y57A10A.28

(Caenorhabditis
elegans)
5 / 9 VAL A  22
TYR A  21
VAL A 226
ILE A 230
LEU A 129
None
DMU  A 310 ( 2.9A)
None
None
None
1.41A 4jtqB-5eikA:
undetectable
4jtqB-5eikA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
4mzv EPITHELIAL CELL
ADHESION MOLECULE

(Homo
sapiens)
4 / 6 LEU A 242
GLU A 169
VAL A 212
ALA A 213
DMU  A 301 ( 4.6A)
None
None
None
0.87A 4nkxA-4mzvA:
undetectable
4nkxA-4mzvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5eik UNCHARACTERIZED
PROTEIN Y57A10A.28

(Caenorhabditis
elegans)
4 / 8 PHE A 229
TYR A 222
GLY A 160
ILE A 157
None
None
None
DMU  A 312 ( 4.7A)
0.96A 4qoiA-5eikA:
undetectable
4qoiB-5eikA:
undetectable
4qoiA-5eikA:
23.55
4qoiB-5eikA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)
5da0 SULPHATE TRANSPORTER
(Deinococcus
geothermalis)
5 / 12 THR A 253
GLY A 296
SER A 301
LEU A 300
ALA A  65
DMU  A 602 ( 4.9A)
None
None
None
None
1.13A 4uckB-5da0A:
undetectable
4uckB-5da0A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)
4mzv EPITHELIAL CELL
ADHESION MOLECULE

(Homo
sapiens)
5 / 12 ILE A 146
ASP A 253
THR A 141
ASN A 120
ILE A 209
DMU  A 301 (-4.6A)
None
None
None
None
0.96A 4xe0A-4mzvA:
undetectable
4xe0A-4mzvA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus)
4 / 7 LEU A 145
LYS A 140
LEU A  17
GLU A  13
None
None
DMU  A 501 ( 4.8A)
None
1.02A 4z4fA-6d0nA:
undetectable
4z4fA-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus)
4 / 6 PHE A 388
LEU A 227
SER A 390
GLY A 230
DMU  A 502 (-3.6A)
None
None
None
1.08A 5o4yF-6d0nA:
undetectable
5o4yF-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus)
3 / 3 HIS A 179
SER A 178
LYS A 176
None
None
DMU  A 501 (-3.8A)
1.36A 5os7A-6d0nA:
undetectable
5os7A-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)
4a01 PROTON
PYROPHOSPHATASE

(Vigna
radiata)
4 / 7 GLU A 423
TYR A 430
ALA A 531
GLY A 533
None
DMU  A1774 (-4.7A)
None
K  A1772 ( 4.6A)
0.93A 5uxdA-4a01A:
1.1
5uxdA-4a01A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)
3tij NUPC FAMILY PROTEIN
(Vibrio
cholerae)
5 / 12 GLY A 137
ILE A 125
LEU A 128
GLY A 131
ALA A 146
None
None
DMU  A 425 ( 4.5A)
DMU  A 425 ( 4.3A)
None
1.04A 6c2mA-3tijA:
undetectable
6c2mA-3tijA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)
5da0 SULPHATE TRANSPORTER
(Deinococcus
geothermalis)
5 / 12 GLY A 267
ARG A 118
LEU A 240
GLY A 238
ALA A 117
None
None
DMU  A 601 (-3.9A)
None
None
1.11A 6c2mA-5da0A:
undetectable
6c2mA-5da0A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5da0 SULPHATE TRANSPORTER
(Deinococcus
geothermalis)
5 / 11 PRO A 229
SER A 373
LEU A 107
SER A 235
LEU A 236
None
None
None
None
DMU  A 601 ( 4.0A)
1.28A 6dlzA-5da0A:
undetectable
6dlzD-5da0A:
undetectable
6dlzA-5da0A:
11.56
6dlzD-5da0A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5da0 SULPHATE TRANSPORTER
(Deinococcus
geothermalis)
5 / 11 PRO A 229
SER A 373
LEU A 107
SER A 235
LEU A 236
None
None
None
None
DMU  A 601 ( 4.0A)
1.29A 6dm1A-5da0A:
undetectable
6dm1D-5da0A:
undetectable
6dm1A-5da0A:
11.56
6dm1D-5da0A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus)
3 / 3 HIS A 179
SER A 178
LYS A 176
None
None
DMU  A 501 (-3.8A)
1.36A 6gmdB-6d0nA:
undetectable
6gmdB-6d0nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)
4mzv EPITHELIAL CELL
ADHESION MOLECULE

(Homo
sapiens)
4 / 5 LEU A  34
TYR A  32
ILE A 146
MET A  69
None
None
DMU  A 301 (-4.6A)
None
1.00A 6hd6A-4mzvA:
undetectable
6hd6A-4mzvA:
16.29