SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DMU'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KLM_A_SPPA999_1 (HIV-1 REVERSETRANSCRIPTASE) |
4mzv | EPITHELIAL CELLADHESION MOLECULE (Homosapiens) | 5 / 11 | LEU A 166LYS A 168TYR A 186TYR A 157LEU A 233 | NoneNoneNoneNoneDMU A 301 ( 4.6A) | 1.48A | 1klmA-4mzvA:2.7 | 1klmA-4mzvA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2A3B_B_CFFB2434_1 (CHITINASE) |
4mzv | EPITHELIAL CELLADHESION MOLECULE (Homosapiens) | 4 / 6 | GLU A 223ASP A 219PHE A 226ARG A 173 | NoneNoneNoneDMU A 301 (-4.0A) | 1.46A | 2a3bB-4mzvA:undetectable | 2a3bB-4mzvA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BXP_A_P1ZA3001_1 (SERUM ALBUMIN) |
3tij | NUPC FAMILY PROTEIN (Vibriocholerae) | 5 / 12 | LEU A 406LEU A 403ALA A 400ILE A 399ALA A 367 | NoneNoneNoneDMU A 424 ( 4.7A)None | 1.24A | 2bxpA-3tijA:undetectable | 2bxpA-3tijA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2F78_A_BEZA1003_0 (HTH-TYPETRANSCRIPTIONALREGULATOR BENM) |
6d0n | CLC-TYPEFLUORIDE/PROTONANTIPORTER (Enterococcuscasseliflavus) | 4 / 7 | SER A 21LEU A 169HIS A 180THR A 144 | NoneNoneDMU A 501 ( 4.6A)DMU A 501 (-3.9A) | 1.14A | 2f78A-6d0nA:undetectable | 2f78A-6d0nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2F8D_A_BEZA1002_0 (HTH-TYPETRANSCRIPTIONALREGULATOR BENM) |
3tij | NUPC FAMILY PROTEIN (Vibriocholerae) | 5 / 10 | LEU A 379GLY A 377LEU A 376LEU A 375ILE A 372 | NoneNoneNoneNoneDMU A 420 (-3.9A) | 1.02A | 2f8dA-3tijA:undetectable | 2f8dA-3tijA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2V0M_D_KLND1499_1 (CYTOCHROME P450 3A4) |
3tij | NUPC FAMILY PROTEIN (Vibriocholerae) | 4 / 5 | PHE A 97PHE A 270PHE A 333ILE A 277 | NoneDMU A 422 ( 4.1A)URI A 419 (-4.9A)None | 1.37A | 2v0mD-3tijA:undetectable | 2v0mD-3tijA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XFS_A_J01A500_1 (ORF12) |
3tij | NUPC FAMILY PROTEIN (Vibriocholerae) | 4 / 8 | LEU A 376ARG A 387GLY A 388ALA A 391 | NoneNoneNoneDMU A 420 (-4.9A) | 0.89A | 2xfsA-3tijA:undetectable | 2xfsA-3tijA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XH9_A_J01A1436_1 (ORF12) |
3tij | NUPC FAMILY PROTEIN (Vibriocholerae) | 4 / 8 | LEU A 376ARG A 387GLY A 388ALA A 391 | NoneNoneNoneDMU A 420 (-4.9A) | 0.90A | 2xh9A-3tijA:undetectable | 2xh9A-3tijA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ADS_A_IMNA2_2 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) |
6d0n | CLC-TYPEFLUORIDE/PROTONANTIPORTER (Enterococcuscasseliflavus) | 4 / 6 | ILE A 364ILE A 389LEU A 376PHE A 379 | NoneDMU A 502 ( 4.7A)NoneNone | 1.13A | 3adsA-6d0nA:undetectable | 3adsA-6d0nA:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3IW1_A_ASDA1223_1 (CYTOCHROME P450CYP125) |
5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) | 5 / 12 | ILE A 290GLN A 287PRO A 37ILE A 139VAL A 335 | NoneNoneNoneNoneDMU A 601 (-4.7A) | 1.23A | 3iw1A-5da0A:undetectable | 3iw1A-5da0A:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3KO0_H_TFPH202_1 (PROTEIN S100-A4) |
4a01 | PROTONPYROPHOSPHATASE (Vignaradiata) | 5 / 12 | GLU A 747LEU A 232ILE A 107PHE A 99PHE A 240 | NoneNoneNoneDMU A1776 (-4.5A)None | 1.39A | 3ko0G-4a01A:undetectable3ko0H-4a01A:1.23ko0I-4a01A:1.83ko0J-4a01A:1.7 | 3ko0G-4a01A:8.763ko0H-4a01A:8.763ko0I-4a01A:8.763ko0J-4a01A:8.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3N8Y_B_DIFB585_1 (PROSTAGLANDIN G/HSYNTHASE 1) |
4a01 | PROTONPYROPHOSPHATASE (Vignaradiata) | 5 / 12 | ILE A 643GLY A 646ALA A 647LEU A 651LEU A 654 | DMU A1776 ( 4.9A)NoneDMU A1776 ( 4.1A)DMU A1775 ( 4.9A)None | 0.73A | 3n8yB-4a01A:undetectable | 3n8yB-4a01A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3N8Z_B_FLPB1701_1 (PROSTAGLANDIN G/HSYNTHASE 1) |
4a01 | PROTONPYROPHOSPHATASE (Vignaradiata) | 5 / 12 | LEU A 239ILE A 643GLY A 646ALA A 647LEU A 651 | NoneDMU A1776 ( 4.9A)NoneDMU A1776 ( 4.1A)DMU A1775 ( 4.9A) | 0.94A | 3n8zB-4a01A:0.5 | 3n8zB-4a01A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3R24_A_SAMA302_1 (2'-O-METHYLTRANSFERASE) |
4mzv | EPITHELIAL CELLADHESION MOLECULE (Homosapiens) | 3 / 3 | TYR A 174ASP A 232ASP A 219 | DMU A 301 (-4.7A)DMU A 301 (-3.5A)None | 0.67A | 3r24A-4mzvA:undetectable | 3r24A-4mzvA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3SUF_A_SUEA1201_1 (NS3 PROTEASE, NS4APROTEIN) |
3tij | NUPC FAMILY PROTEIN (Vibriocholerae) | 5 / 12 | GLY A 137LEU A 128GLY A 131ALA A 146ALA A 147 | NoneDMU A 425 ( 4.5A)DMU A 425 ( 4.3A)NoneNone | 1.02A | 3sufA-3tijA:undetectable | 3sufA-3tijA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3SUF_A_SUEA1201_1 (NS3 PROTEASE, NS4APROTEIN) |
5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) | 5 / 12 | GLY A 267ARG A 118LEU A 240GLY A 238ALA A 117 | NoneNoneDMU A 601 (-3.9A)NoneNone | 1.00A | 3sufA-5da0A:undetectable | 3sufA-5da0A:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3T3S_A_9PLA1_1 (CYTOCHROME P450 2A13) |
5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) | 5 / 9 | PHE A 42ALA A 142ALA A 336THR A 339LEU A 83 | NoneNoneNoneDMU A 601 (-3.4A)None | 1.02A | 3t3sA-5da0A:undetectable | 3t3sA-5da0A:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TI1_A_B49A299_1 (CYCLIN-DEPENDENTKINASE 2) |
2bbh | DIVALENT CATIONTRANSPORT-RELATEDPROTEIN (Thermotogamaritima) | 5 / 9 | ILE A 225VAL A 146PHE A 113LEU A 177ASP A 179 | NoneNoneDMU A 402 (-4.3A)DMU A 402 ( 4.7A)DMU A 404 (-4.6A) | 1.26A | 3ti1A-2bbhA:undetectable | 3ti1A-2bbhA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4BVA_B_T3B1314_1 (THIOMORPHOLINE-CARBOXYLATE DEHYDROGENASE) |
4a01 | PROTONPYROPHOSPHATASE (Vignaradiata) | 5 / 12 | ARG A 562PHE A 751PHE A 754HIS A 758GLU A 225 | NoneNoneNoneDMU A1778 (-3.9A)None | 1.24A | 4bvaB-4a01A:undetectable | 4bvaB-4a01A:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4EVR_A_BEZA401_0 (PUTATIVE ABCTRANSPORTER SUBUNIT,SUBSTRATE-BINDINGCOMPONENT) |
4a01 | PROTONPYROPHOSPHATASE (Vignaradiata) | 5 / 11 | LEU A 743VAL A 649PHE A 99SER A 236PHE A 103 | NoneNoneDMU A1776 (-4.5A)NoneNone | 1.17A | 4evrA-4a01A:undetectable | 4evrA-4a01A:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4F3T_A_IPHA902_0 (PROTEIN ARGONAUTE-2) |
6d0n | CLC-TYPEFLUORIDE/PROTONANTIPORTER (Enterococcuscasseliflavus) | 4 / 6 | LEU A 145LYS A 140LEU A 17GLU A 13 | NoneNoneDMU A 501 ( 4.8A)None | 1.09A | 4f3tA-6d0nA:undetectable | 4f3tA-6d0nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4HFP_D_15UD402_1 (PROTHROMBIN) |
3omn | CYTOCHROME COXIDASE, AA3 TYPE,SUBUNIT I (Rhodobactersphaeroides) | 5 / 12 | TRP A 439LEU A 34ILE A 515ALA A 428VAL A 111 | NoneDMU A 7 (-4.3A)DMU A 7 ( 4.4A)NoneHEA A 1 (-4.5A) | 1.05A | 4hfpD-3omnA:undetectable | 4hfpD-3omnA:17.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4JTQ_A_FLPA401_1 (ALDO-KETO REDUCTASEFAMILY 1 MEMBER C2) |
5eik | UNCHARACTERIZEDPROTEIN Y57A10A.28 (Caenorhabditiselegans) | 5 / 10 | VAL A 22TYR A 21VAL A 226ILE A 230LEU A 129 | NoneDMU A 310 ( 2.9A)NoneNoneNone | 1.49A | 4jtqA-5eikA:undetectable | 4jtqA-5eikA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4JTQ_B_FLPB401_1 (ALDO-KETO REDUCTASEFAMILY 1 MEMBER C2) |
5eik | UNCHARACTERIZEDPROTEIN Y57A10A.28 (Caenorhabditiselegans) | 5 / 9 | VAL A 22TYR A 21VAL A 226ILE A 230LEU A 129 | NoneDMU A 310 ( 2.9A)NoneNoneNone | 1.41A | 4jtqB-5eikA:undetectable | 4jtqB-5eikA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4NKX_A_STRA601_2 (STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE) |
4mzv | EPITHELIAL CELLADHESION MOLECULE (Homosapiens) | 4 / 6 | LEU A 242GLU A 169VAL A 212ALA A 213 | DMU A 301 ( 4.6A)NoneNoneNone | 0.87A | 4nkxA-4mzvA:undetectable | 4nkxA-4mzvA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QOI_A_ML1A303_1 (RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE[QUINONE]) |
5eik | UNCHARACTERIZEDPROTEIN Y57A10A.28 (Caenorhabditiselegans) | 4 / 8 | PHE A 229TYR A 222GLY A 160ILE A 157 | NoneNoneNoneDMU A 312 ( 4.7A) | 0.96A | 4qoiA-5eikA:undetectable4qoiB-5eikA:undetectable | 4qoiA-5eikA:23.554qoiB-5eikA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4UCK_B_SAMB2409_0 (RNA-DIRECTED RNAPOLYMERASE L) |
5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) | 5 / 12 | THR A 253GLY A 296SER A 301LEU A 300ALA A 65 | DMU A 602 ( 4.9A)NoneNoneNoneNone | 1.13A | 4uckB-5da0A:undetectable | 4uckB-5da0A:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT DELTAISOFORM) |
4mzv | EPITHELIAL CELLADHESION MOLECULE (Homosapiens) | 5 / 12 | ILE A 146ASP A 253THR A 141ASN A 120ILE A 209 | DMU A 301 (-4.6A)NoneNoneNoneNone | 0.96A | 4xe0A-4mzvA:undetectable | 4xe0A-4mzvA:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4Z4F_A_IPHA902_0 (PROTEIN ARGONAUTE-2) |
6d0n | CLC-TYPEFLUORIDE/PROTONANTIPORTER (Enterococcuscasseliflavus) | 4 / 7 | LEU A 145LYS A 140LEU A 17GLU A 13 | NoneNoneDMU A 501 ( 4.8A)None | 1.02A | 4z4fA-6d0nA:undetectable | 4z4fA-6d0nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5O4Y_F_CCSF14_0 (PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2) |
6d0n | CLC-TYPEFLUORIDE/PROTONANTIPORTER (Enterococcuscasseliflavus) | 4 / 6 | PHE A 388LEU A 227SER A 390GLY A 230 | DMU A 502 (-3.6A)NoneNoneNone | 1.08A | 5o4yF-6d0nA:undetectable | 5o4yF-6d0nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5OS7_A_ACTA402_0 (CASEIN KINASE IISUBUNIT ALPHA) |
6d0n | CLC-TYPEFLUORIDE/PROTONANTIPORTER (Enterococcuscasseliflavus) | 3 / 3 | HIS A 179SER A 178LYS A 176 | NoneNoneDMU A 501 (-3.8A) | 1.36A | 5os7A-6d0nA:undetectable | 5os7A-6d0nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UXD_A_ZITA501_1 (MACROLIDE2'-PHOSPHOTRANSFERASE MPHH) |
4a01 | PROTONPYROPHOSPHATASE (Vignaradiata) | 4 / 7 | GLU A 423TYR A 430ALA A 531GLY A 533 | NoneDMU A1774 (-4.7A)None K A1772 ( 4.6A) | 0.93A | 5uxdA-4a01A:1.1 | 5uxdA-4a01A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6C2M_A_SUEA1202_0 (NS3 PROTEASE) |
3tij | NUPC FAMILY PROTEIN (Vibriocholerae) | 5 / 12 | GLY A 137ILE A 125LEU A 128GLY A 131ALA A 146 | NoneNoneDMU A 425 ( 4.5A)DMU A 425 ( 4.3A)None | 1.04A | 6c2mA-3tijA:undetectable | 6c2mA-3tijA:10.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6C2M_A_SUEA1202_0 (NS3 PROTEASE) |
5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) | 5 / 12 | GLY A 267ARG A 118LEU A 240GLY A 238ALA A 117 | NoneNoneDMU A 601 (-3.9A)NoneNone | 1.11A | 6c2mA-5da0A:undetectable | 6c2mA-5da0A:12.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6DLZ_D_CYZD1302_0 (GLUTAMATE RECEPTOR2,VOLTAGE-DEPENDENTCALCIUM CHANNELGAMMA-2 SUBUNIT) |
5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) | 5 / 11 | PRO A 229SER A 373LEU A 107SER A 235LEU A 236 | NoneNoneNoneNoneDMU A 601 ( 4.0A) | 1.28A | 6dlzA-5da0A:undetectable6dlzD-5da0A:undetectable | 6dlzA-5da0A:11.566dlzD-5da0A:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6DM1_D_CYZD1302_0 (GLUTAMATE RECEPTOR2,VOLTAGE-DEPENDENTCALCIUM CHANNELGAMMA-2 SUBUNIT) |
5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) | 5 / 11 | PRO A 229SER A 373LEU A 107SER A 235LEU A 236 | NoneNoneNoneNoneDMU A 601 ( 4.0A) | 1.29A | 6dm1A-5da0A:undetectable6dm1D-5da0A:undetectable | 6dm1A-5da0A:11.566dm1D-5da0A:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GMD_B_ACTB402_0 (CASEIN KINASE IISUBUNIT ALPHA) |
6d0n | CLC-TYPEFLUORIDE/PROTONANTIPORTER (Enterococcuscasseliflavus) | 3 / 3 | HIS A 179SER A 178LYS A 176 | NoneNoneDMU A 501 (-3.8A) | 1.36A | 6gmdB-6d0nA:undetectable | 6gmdB-6d0nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HD6_A_STIA603_1 (TYROSINE-PROTEINKINASE ABL1) |
4mzv | EPITHELIAL CELLADHESION MOLECULE (Homosapiens) | 4 / 5 | LEU A 34TYR A 32ILE A 146MET A 69 | NoneNoneDMU A 301 (-4.6A)None | 1.00A | 6hd6A-4mzvA:undetectable | 6hd6A-4mzvA:16.29 |