SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DME'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3mes CHOLINE KINASE
(Cryptosporidium
parvum) 		4 / 7 GLN A 270
TRP A 371
TRP A 374
GLU A 287
 PT3  A 428 (-3.6A)
DME  A 427 (-3.5A)
DME  A 427 (-4.8A)
PT3  A 428 ( 4.0A)
 1.40A 2aowA-3mesA:
undetectable		 2aowA-3mesA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 3mes CHOLINE KINASE
(Cryptosporidium
parvum) 		4 / 7 GLU A 271
TYR A 301
GLU A 304
TYR A 309
 MG  A 430 (-1.9A)
None
DME  A 427 ( 3.8A)
DME  A 427 (-4.4A)
 1.37A 3ku9B-3mesA:
undetectable		 3ku9B-3mesA:
24.00