SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DLY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.11A 1p7lC-4nz6A:
undetectable		 1p7lC-4nz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.10A 1p7lD-4nz6A:
undetectable		 1p7lD-4nz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.11A 1rg9A-4nz6A:
undetectable		 1rg9A-4nz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.09A 1rg9B-4nz6A:
undetectable		 1rg9B-4nz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.12A 1rg9C-4nz6A:
undetectable		 1rg9C-4nz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 HIS A 177
PRO A 175
THR A 145
ASP A 115
 None
None
DLY  A 403 (-4.6A)
None
 1.10A 1rg9D-4nz6A:
undetectable		 1rg9D-4nz6A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 8 LYS A  33
TYR A  37
ARG A 129
TYR A 341
 PLP  A 358 ( 1.3A)
PLP  A 358 ( 4.6A)
DLY  A 359 ( 2.5A)
PLP  A 358 ( 4.4A)
 0.68A 1xqlA-1rcqA:
39.4
1xqlB-1rcqA:
39.6		 1xqlA-1rcqA:
31.98
1xqlB-1rcqA:
31.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 8 LYS A  33
TYR A  37
ARG A 129
TYR A 341
 PLP  A 358 ( 1.3A)
PLP  A 358 ( 4.6A)
DLY  A 359 ( 2.5A)
PLP  A 358 ( 4.4A)
 0.78A 1xqlA-1rcqA:
39.4
1xqlB-1rcqA:
39.6		 1xqlA-1rcqA:
31.98
1xqlB-1rcqA:
31.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 HIS A 177
PRO A 175
SER A 150
THR A 145
ASP A 115
 None
None
None
DLY  A 403 (-4.6A)
None
 1.27A 5t8sB-4nz6A:
undetectable		 5t8sB-4nz6A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 205
GLY A 332
GLY A 330
VAL A 149
CYH A 268
 None
None
None
DLY  A 403 (-4.4A)
None
 1.15A 5uc1A-4nz6A:
undetectable		 5uc1A-4nz6A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 205
GLY A 332
GLY A 330
VAL A 149
CYH A 268
 None
None
None
DLY  A 403 (-4.4A)
None
 1.13A 5uc1B-4nz6A:
undetectable		 5uc1B-4nz6A:
14.06