SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DLL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 218
THR A 121
SER A 124
ILE A 125
LEU A 136
 DLL  A1441 ( 3.7A)
None
None
None
None
 0.88A 1ddrA-2y4oA:
undetectable		 1ddrA-2y4oA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 218
THR A 121
SER A 124
ILE A 125
LEU A 136
 DLL  A1441 ( 3.7A)
None
None
None
None
 0.90A 1rg7A-2y4oA:
undetectable		 1rg7A-2y4oA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.81A 1usqA-2y4oA:
undetectable		 1usqA-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.80A 1usqB-2y4oA:
undetectable		 1usqB-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.81A 1usqC-2y4oA:
undetectable		 1usqC-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.82A 1usqD-2y4oA:
undetectable		 1usqD-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.82A 1usqE-2y4oA:
undetectable		 1usqE-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.82A 1usqF-2y4oA:
undetectable		 1usqF-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.77A 2jkjA-2y4oA:
undetectable		 2jkjA-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.76A 2jkjB-2y4oA:
undetectable		 2jkjB-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.77A 2jkjC-2y4oA:
undetectable		 2jkjC-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.77A 2jkjE-2y4oA:
undetectable		 2jkjE-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.78A 2jklA-2y4oA:
undetectable		 2jklA-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 6 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.77A 2jklB-2y4oA:
undetectable		 2jklB-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.78A 2jklC-2y4oA:
undetectable		 2jklC-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.80A 2jklD-2y4oA:
undetectable		 2jklD-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.78A 2jklE-2y4oA:
undetectable		 2jklE-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 GLY A 248
PRO A 249
ILE A 240
GLY A 242
 DLL  A1441 ( 4.4A)
DLL  A1441 ( 4.0A)
DLL  A1441 (-4.7A)
DLL  A1441 (-4.1A)
 0.79A 2jklF-2y4oA:
undetectable		 2jklF-2y4oA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		3 / 3 LEU A 324
TYR A 241
GLY A 217
 None
DLL  A1441 (-4.8A)
DLL  A1441 ( 3.8A)
 0.61A 2ocuA-2y4oA:
undetectable		 2ocuA-2y4oA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 218
THR A 121
SER A 124
ILE A 125
LEU A 136
 DLL  A1441 ( 3.7A)
None
None
None
None
 0.96A 4dfrA-2y4oA:
undetectable		 4dfrA-2y4oA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 ILE A 240
GLY A 147
PHE A 140
TYR A 109
 DLL  A1441 (-4.7A)
DLL  A1441 (-3.6A)
DLL  A1441 (-3.6A)
None
 0.92A 4iqqA-2y4oA:
undetectable		 4iqqA-2y4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 8 ILE A 240
GLY A 147
PHE A 140
TYR A 109
 DLL  A1441 (-4.7A)
DLL  A1441 (-3.6A)
DLL  A1441 (-3.6A)
None
 0.78A 4iqqD-2y4oA:
undetectable		 4iqqD-2y4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 7 ILE A 240
GLY A 147
PHE A 140
TYR A 109
 DLL  A1441 (-4.7A)
DLL  A1441 (-3.6A)
DLL  A1441 (-3.6A)
None
 0.90A 5h3aA-2y4oA:
undetectable		 5h3aA-2y4oA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		5 / 12 TYR A 305
THR A 105
GLU A 245
GLY A 248
VAL A 251
 None
None
DLL  A1441 ( 4.6A)
DLL  A1441 ( 4.4A)
None
 1.45A 5jo9A-2y4oA:
5.5		 5jo9A-2y4oA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2y4o PHENYLACETATE-COENZY
ME A LIGASE
(Burkholderia
cenocepacia) 		4 / 8 ILE A 240
GLY A 147
PHE A 140
TYR A 109
 DLL  A1441 (-4.7A)
DLL  A1441 (-3.6A)
DLL  A1441 (-3.6A)
None
 0.78A 5nooD-2y4oA:
undetectable		 5nooD-2y4oA:
20.26