SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DL7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2H42_C_VIAC903_2 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	3gyu	NUCLEAR HORMONE RECEPTOR OF THE STEROID/THYROID HORMONE RECEPTORS SUPERFAMILY (Strongyloides stercoralis)	3 / 3	ASN A 557 ILE A 621 MET A 625	None DL7 A 200 ( 4.5A) DL7 A 200 ( 4.7A)	0.71A	2h42C-3gyuA: undetectable	2h42C-3gyuA: 22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AFG_B_QMRB1214_1 (CAPITELLA TELETA ACHBP)	3gyu	NUCLEAR HORMONE RECEPTOR OF THE STEROID/THYROID HORMONE RECEPTORS SUPERFAMILY (Strongyloides stercoralis)	5 / 9	ILE A 598 PHE A 626 PHE A 623 TRP A 611 VAL A 601	None None None DL7 A 200 ( 4.2A) None	1.49A	4afgA-3gyuA: 0.0 4afgE-3gyuA: 0.0	4afgA-3gyuA: 23.81 4afgE-3gyuA: 23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AYC_A_1YNA502_1 (PROTEIN CYP51)	3gyu	NUCLEAR HORMONE RECEPTOR OF THE STEROID/THYROID HORMONE RECEPTORS SUPERFAMILY (Strongyloides stercoralis)	5 / 12	ALA A 542 MET A 625 ALA A 735 THR A 738 LEU A 556	None DL7 A 200 ( 4.7A) None None None	1.31A	6aycA-3gyuA: undetectable	6aycA-3gyuA: 19.07

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2H42_C_VIAC903_2","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","3gyu","NUCLEAR HORMONE RECEPTOR OF THE STEROID\/THYROID HORMONE RECEPTORS SUPERFAMILY","Strongyloides stercoralis",3,"ASN A 557;ILE A 621;MET A 625","None;DL7 A 200 ( 4.5A);DL7 A 200 ( 4.7A)","0.71A","2h42C-3gyuA:undetectable",null],["4AFG_B_QMRB1214_1","CAPITELLA TELETA ACHBP;CAPITELLA TELETA ACHBP;CAPITELLA TELETA ACHBP","3gyu","NUCLEAR HORMONE RECEPTOR OF THE STEROID\/THYROID HORMONE RECEPTORS SUPERFAMILY","Strongyloides stercoralis",5,"ILE A 598;PHE A 626;PHE A 623;TRP A 611;VAL A 601","None;None;None;DL7 A 200 ( 4.2A);None","1.49A","4afgA-3gyuA:0.0;4afgE-3gyuA:0.0","2h42C-3gyuA:22.74"],["6AYC_A_1YNA502_1","PROTEIN CYP51","3gyu","NUCLEAR HORMONE RECEPTOR OF THE STEROID\/THYROID HORMONE RECEPTORS SUPERFAMILY","Strongyloides stercoralis",5,"ALA A 542;MET A 625;ALA A 735;THR A 738;LEU A 556","None;DL7 A 200 ( 4.7A);None;None;None","1.31A","6aycA-3gyuA:undetectable","4afgA-3gyuA:23.81;4afgE-3gyuA:23.81"]]