SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DL1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1M17_A_AQ4A999_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	7 / 12	ALA A 237 LYS A 239 GLU A 259 LEU A 286 GLY A 294 LEU A 347 ASP A 358	DL1 A 601 (-3.4A) DL1 A 601 ( 4.1A) None None DL1 A 601 (-3.5A) DL1 A 601 (-3.9A) DL1 A 601 (-3.1A)	0.84A	1m17A-6bfnA: 24.6	1m17A-6bfnA: 14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T46_A_STIA3_1 (HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	8 / 12	VAL A 226 ALA A 237 LYS A 239 GLU A 259 LEU A 263 VAL A 272 GLY A 294 LEU A 347	None DL1 A 601 (-3.4A) DL1 A 601 ( 4.1A) None None DL1 A 601 ( 4.8A) DL1 A 601 (-3.5A) DL1 A 601 (-3.9A)	0.92A	1t46A-6bfnA: 23.9	1t46A-6bfnA: 13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	ALA A 237 GLY A 294 ASP A 298 LEU A 347 ASP A 358 PHE A 359	DL1 A 601 (-3.4A) DL1 A 601 (-3.5A) DL1 A 601 ( 4.9A) DL1 A 601 (-3.9A) DL1 A 601 (-3.1A) None	1.01A	1xkkA-6bfnA: 23.4	1xkkA-6bfnA: 13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ITY_A_IREA2020_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	9 / 12	GLY A 219 VAL A 226 ALA A 237 LYS A 239 GLU A 259 LEU A 286 GLY A 294 LEU A 347 ASP A 358	DL1 A 601 ( 4.1A) None DL1 A 601 (-3.4A) DL1 A 601 ( 4.1A) None None DL1 A 601 (-3.5A) DL1 A 601 (-3.9A) DL1 A 601 (-3.1A)	1.00A	2ityA-6bfnA: 25.0	2ityA-6bfnA: 14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ITZ_A_IREA2021_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	8 / 12	VAL A 226 ALA A 237 LYS A 239 GLU A 259 GLY A 294 ASP A 298 LEU A 347 ASP A 358	None DL1 A 601 (-3.4A) DL1 A 601 ( 4.1A) None DL1 A 601 (-3.5A) DL1 A 601 ( 4.9A) DL1 A 601 (-3.9A) DL1 A 601 (-3.1A)	1.04A	2itzA-6bfnA: 25.0	2itzA-6bfnA: 13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7J_A_B49A1294_1 (PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	ILE A 218 VAL A 226 ALA A 237 GLY A 294 LEU A 347 ASP A 358	DL1 A 601 (-4.0A) None DL1 A 601 (-3.4A) DL1 A 601 (-3.5A) DL1 A 601 (-3.9A) DL1 A 601 (-3.1A)	0.70A	2y7jA-6bfnA: 23.3	2y7jA-6bfnA: 13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7J_B_B49B1294_1 (PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 10	ILE A 218 VAL A 226 ALA A 237 GLY A 294 LEU A 347 ASP A 358	DL1 A 601 (-4.0A) None DL1 A 601 (-3.4A) DL1 A 601 (-3.5A) DL1 A 601 (-3.9A) DL1 A 601 (-3.1A)	0.59A	2y7jB-6bfnA: 23.8	2y7jB-6bfnA: 13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7J_D_B49D1294_1 (PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 10	ILE A 218 VAL A 226 ALA A 237 GLY A 294 ASP A 298 LEU A 347	DL1 A 601 (-4.0A) None DL1 A 601 (-3.4A) DL1 A 601 (-3.5A) DL1 A 601 ( 4.9A) DL1 A 601 (-3.9A)	0.69A	2y7jD-6bfnA: 24.1	2y7jD-6bfnA: 13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	7 / 12	VAL A 226 ALA A 237 LEU A 286 GLY A 294 LEU A 347 ASP A 358 PHE A 359	None DL1 A 601 (-3.4A) None DL1 A 601 (-3.5A) DL1 A 601 (-3.9A) DL1 A 601 (-3.1A) None	0.86A	3bbtD-6bfnA: 23.4	3bbtD-6bfnA: 17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MIY_A_B49A1_1 (TYROSINE-PROTEIN KINASE ITK/TSK)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	8 / 11	ILE A 218 ALA A 237 LYS A 239 VAL A 272 PHE A 290 GLY A 294 LEU A 347 ASP A 358	DL1 A 601 (-4.0A) DL1 A 601 (-3.4A) DL1 A 601 ( 4.1A) DL1 A 601 ( 4.8A) DL1 A 601 (-4.3A) DL1 A 601 (-3.5A) DL1 A 601 (-3.9A) DL1 A 601 (-3.1A)	0.61A	3miyA-6bfnA: 25.0	3miyA-6bfnA: 15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MIY_B_B49B2_1 (TYROSINE-PROTEIN KINASE ITK/TSK)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 9	ILE A 218 ALA A 237 LYS A 239 PHE A 290 GLY A 294 LEU A 347	DL1 A 601 (-4.0A) DL1 A 601 (-3.4A) DL1 A 601 ( 4.1A) DL1 A 601 (-4.3A) DL1 A 601 (-3.5A) DL1 A 601 (-3.9A)	0.57A	3miyB-6bfnA: 24.8	3miyB-6bfnA: 15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OG7_A_032A1_1 (AKAP9-BRAF FUSION PROTEIN)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	ILE A 218 VAL A 226 ALA A 237 LYS A 239 LEU A 263 PHE A 359	DL1 A 601 (-4.0A) None DL1 A 601 (-3.4A) DL1 A 601 ( 4.1A) None None	1.27A	3og7A-6bfnA: 24.6	3og7A-6bfnA: 13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I22_A_IREA9001_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	8 / 12	GLY A 219 VAL A 226 ALA A 237 LEU A 286 GLY A 294 ASP A 298 LEU A 347 ASP A 358	DL1 A 601 ( 4.1A) None DL1 A 601 (-3.4A) None DL1 A 601 (-3.5A) DL1 A 601 ( 4.9A) DL1 A 601 (-3.9A) DL1 A 601 (-3.1A)	0.80A	4i22A-6bfnA: 23.0	4i22A-6bfnA: 13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KS8_A_B49A701_1 (SERINE/THREONINE-PRO TEIN KINASE PAK 6)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	8 / 10	ILE A 218 ALA A 237 VAL A 272 PHE A 290 LEU A 291 GLY A 294 LEU A 347 ASP A 358	DL1 A 601 (-4.0A) DL1 A 601 (-3.4A) DL1 A 601 ( 4.8A) DL1 A 601 (-4.3A) DL1 A 601 (-4.4A) DL1 A 601 (-3.5A) DL1 A 601 (-3.9A) DL1 A 601 (-3.1A)	0.56A	4ks8A-6bfnA: 24.7	4ks8A-6bfnA: 14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OTI_A_MI1A1001_1 (SERINE/THREONINE-PRO TEIN KINASE N1)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	8 / 12	GLY A 219 GLY A 221 GLY A 224 VAL A 226 ALA A 237 LYS A 239 VAL A 272 ASP A 358	DL1 A 601 ( 4.1A) None None None DL1 A 601 (-3.4A) DL1 A 601 ( 4.1A) DL1 A 601 ( 4.8A) DL1 A 601 (-3.1A)	0.82A	4otiA-6bfnA: 17.1	4otiA-6bfnA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QMZ_A_B49A401_1 (SERINE/THREONINE-PRO TEIN KINASE 24)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	ILE A 218 GLY A 219 VAL A 226 ALA A 237 LEU A 291 LEU A 347	DL1 A 601 (-4.0A) DL1 A 601 ( 4.1A) None DL1 A 601 (-3.4A) DL1 A 601 (-4.4A) DL1 A 601 (-3.9A)	0.49A	4qmzA-6bfnA: 24.0	4qmzA-6bfnA: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	VAL A 226 ALA A 237 LYS A 239 SER A 295 GLY A 357 GLY A 360	None DL1 A 601 (-3.4A) DL1 A 601 ( 4.1A) DL1 A 601 ( 4.6A) DL1 A 601 ( 4.8A) None	1.10A	4rzvB-6bfnA: 24.6	4rzvB-6bfnA: 15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XV2_A_P06A801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	VAL A 226 ALA A 237 LYS A 239 GLY A 357 ASP A 358 PHE A 359	None DL1 A 601 (-3.4A) DL1 A 601 ( 4.1A) DL1 A 601 ( 4.8A) DL1 A 601 (-3.1A) None	1.01A	4xv2A-6bfnA: 24.4	4xv2A-6bfnA: 14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XV2_B_P06B801_1 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	5 / 12	ALA A 237 LYS A 239 GLY A 357 ASP A 358 PHE A 359	DL1 A 601 (-3.4A) DL1 A 601 ( 4.1A) DL1 A 601 ( 4.8A) DL1 A 601 (-3.1A) None	0.96A	4xv2B-6bfnA: 24.8	4xv2B-6bfnA: 14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5H2U_C_1N1C501_1 (PROTEIN-TYROSINE KINASE 6)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	5 / 12	ALA A 237 GLY A 294 LEU A 347 GLY A 357 ASP A 358	DL1 A 601 (-3.4A) DL1 A 601 (-3.5A) DL1 A 601 (-3.9A) DL1 A 601 ( 4.8A) DL1 A 601 (-3.1A)	0.57A	5h2uC-6bfnA: 24.1	5h2uC-6bfnA: 14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5H2U_D_1N1D504_1 (PROTEIN-TYROSINE KINASE 6)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	VAL A 226 ALA A 237 GLY A 294 LEU A 347 GLY A 357 ASP A 358	None DL1 A 601 (-3.4A) DL1 A 601 (-3.5A) DL1 A 601 (-3.9A) DL1 A 601 ( 4.8A) DL1 A 601 (-3.1A)	0.59A	5h2uD-6bfnA: 24.2	5h2uD-6bfnA: 14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IZJ_G_AZ1G2_1 (CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA 47P-AZ1-DAR-DAR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	5 / 7	GLY A 219 GLY A 221 VAL A 226 LYS A 239 LEU A 241	DL1 A 601 ( 4.1A) None None DL1 A 601 ( 4.1A) None	0.69A	5izjA-6bfnA: 20.4	5izjA-6bfnA: 11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NNW_D_GCSD302_1 (25 KDA PROTEIN ELICITOR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	4 / 7	ASP A 340 GLY A 339 HIS A 338 ASP A 358	None None None DL1 A 601 (-3.1A)	1.06A	5nnwD-6bfnA: undetectable	5nnwD-6bfnA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NO9_D_95ZD302_1 (25 KDA PROTEIN ELICITOR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	4 / 7	ASP A 340 GLY A 339 HIS A 338 ASP A 358	None None None DL1 A 601 (-3.1A)	1.05A	5no9D-6bfnA: undetectable	5no9D-6bfnA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VC3_A_DB8A601_1 (WEE1-LIKE PROTEIN KINASE)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	ILE A 218 GLY A 219 ALA A 237 GLU A 259 GLY A 294 ASP A 298	DL1 A 601 (-4.0A) DL1 A 601 ( 4.1A) DL1 A 601 (-3.4A) None DL1 A 601 (-3.5A) DL1 A 601 ( 4.9A)	0.58A	5vc3A-6bfnA: 24.7	5vc3A-6bfnA: 13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOO_E_C2FE3001_0 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	5 / 12	GLY A 222 VAL A 272 LEU A 356 GLY A 360 SER A 255	None DL1 A 601 ( 4.8A) None None None	1.13A	5vooE-6bfnA: undetectable	5vooE-6bfnA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOO_F_C2FF3001_0 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	5 / 12	GLY A 222 VAL A 272 LEU A 356 GLY A 360 SER A 255	None DL1 A 601 ( 4.8A) None None None	1.14A	5vooF-6bfnA: undetectable	5vooF-6bfnA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOP_B_C2FB3001_0 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	5 / 12	GLY A 222 VAL A 272 LEU A 356 GLY A 360 SER A 255	None DL1 A 601 ( 4.8A) None None None	1.17A	5vopB-6bfnA: undetectable	5vopB-6bfnA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YU9_A_1E8A1101_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	GLY A 219 VAL A 226 ALA A 237 LEU A 286 LEU A 347 ASP A 358	DL1 A 601 ( 4.1A) None DL1 A 601 (-3.4A) None DL1 A 601 (-3.9A) DL1 A 601 (-3.1A)	0.63A	5yu9A-6bfnA: 22.9	5yu9A-6bfnA: 29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YU9_B_1E8B1101_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	GLY A 219 VAL A 226 ALA A 237 LEU A 286 LEU A 347 ASP A 358	DL1 A 601 ( 4.1A) None DL1 A 601 (-3.4A) None DL1 A 601 (-3.9A) DL1 A 601 (-3.1A)	0.60A	5yu9B-6bfnA: 22.9	5yu9B-6bfnA: 29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YU9_C_1E8C1101_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	5 / 12	VAL A 226 ALA A 237 LEU A 286 GLY A 294 ASP A 358	None DL1 A 601 (-3.4A) None DL1 A 601 (-3.5A) DL1 A 601 (-3.1A)	0.48A	5yu9C-6bfnA: 22.6	5yu9C-6bfnA: 29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YU9_D_1E8D1101_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	5 / 12	VAL A 226 ALA A 237 GLY A 294 LEU A 347 ASP A 358	None DL1 A 601 (-3.4A) DL1 A 601 (-3.5A) DL1 A 601 (-3.9A) DL1 A 601 (-3.1A)	0.49A	5yu9D-6bfnA: 23.1	5yu9D-6bfnA: 29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	5 / 12	LEU A 241 HIS A 338 VAL A 272 THR A 258 LEU A 257	None None DL1 A 601 ( 4.8A) None None	1.27A	6djzB-6bfnA: undetectable	6djzB-6bfnA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FNM_A_1N1A1001_1 (-)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	7 / 12	ILE A 218 VAL A 226 ALA A 237 LYS A 239 GLU A 259 GLY A 294 LEU A 347	DL1 A 601 (-4.0A) None DL1 A 601 (-3.4A) DL1 A 601 ( 4.1A) None DL1 A 601 (-3.5A) DL1 A 601 (-3.9A)	0.82A	6fnmA-6bfnA: 24.4	6fnmA-6bfnA: 14.24

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1M17_A_AQ4A999_1","EPIDERMAL GROWTH FACTOR RECEPTOR","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",7,"ALA A 237;LYS A 239;GLU A 259;LEU A 286;GLY A 294;LEU A 347;ASP A 358","DL1 A 601 (-3.4A);DL1 A 601 ( 4.1A);None;None;DL1 A 601 (-3.5A);DL1 A 601 (-3.9A);DL1 A 601 (-3.1A)","0.84A","1m17A-6bfnA:24.6",null],["1T46_A_STIA3_1","HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",8,"VAL A 226;ALA A 237;LYS A 239;GLU A 259;LEU A 263;VAL A 272;GLY A 294;LEU A 347","None;DL1 A 601 (-3.4A);DL1 A 601 ( 4.1A);None;None;DL1 A 601 ( 4.8A);DL1 A 601 (-3.5A);DL1 A 601 (-3.9A)","0.92A","1t46A-6bfnA:23.9","1m17A-6bfnA:14.47"],["1XKK_A_FMMA91_1","EPIDERMAL GROWTH FACTOR RECEPTOR","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"ALA A 237;GLY A 294;ASP A 298;LEU A 347;ASP A 358;PHE A 359","DL1 A 601 (-3.4A);DL1 A 601 (-3.5A);DL1 A 601 ( 4.9A);DL1 A 601 (-3.9A);DL1 A 601 (-3.1A);None","1.01A","1xkkA-6bfnA:23.4","1t46A-6bfnA:13.82"],["2ITY_A_IREA2020_1","EPIDERMAL GROWTH FACTOR RECEPTOR","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",9,"GLY A 219;VAL A 226;ALA A 237;LYS A 239;GLU A 259;LEU A 286;GLY A 294;LEU A 347;ASP A 358","DL1 A 601 ( 4.1A);None;DL1 A 601 (-3.4A);DL1 A 601 ( 4.1A);None;None;DL1 A 601 (-3.5A);DL1 A 601 (-3.9A);DL1 A 601 (-3.1A)","1.00A","2ityA-6bfnA:25.0","1xkkA-6bfnA:13.75"],["2ITZ_A_IREA2021_1","EPIDERMAL GROWTH FACTOR RECEPTOR","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",8,"VAL A 226;ALA A 237;LYS A 239;GLU A 259;GLY A 294;ASP A 298;LEU A 347;ASP A 358","None;DL1 A 601 (-3.4A);DL1 A 601 ( 4.1A);None;DL1 A 601 (-3.5A);DL1 A 601 ( 4.9A);DL1 A 601 (-3.9A);DL1 A 601 (-3.1A)","1.04A","2itzA-6bfnA:25.0","2ityA-6bfnA:14.24"],["2Y7J_A_B49A1294_1","PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS\/LIVER ISOFORM","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"ILE A 218;VAL A 226;ALA A 237;GLY A 294;LEU A 347;ASP A 358","DL1 A 601 (-4.0A);None;DL1 A 601 (-3.4A);DL1 A 601 (-3.5A);DL1 A 601 (-3.9A);DL1 A 601 (-3.1A)","0.70A","2y7jA-6bfnA:23.3","2itzA-6bfnA:13.56"],["2Y7J_B_B49B1294_1","PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS\/LIVER ISOFORM","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"ILE A 218;VAL A 226;ALA A 237;GLY A 294;LEU A 347;ASP A 358","DL1 A 601 (-4.0A);None;DL1 A 601 (-3.4A);DL1 A 601 (-3.5A);DL1 A 601 (-3.9A);DL1 A 601 (-3.1A)","0.59A","2y7jB-6bfnA:23.8","2y7jA-6bfnA:13.20"],["2Y7J_D_B49D1294_1","PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS\/LIVER ISOFORM","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"ILE A 218;VAL A 226;ALA A 237;GLY A 294;ASP A 298;LEU A 347","DL1 A 601 (-4.0A);None;DL1 A 601 (-3.4A);DL1 A 601 (-3.5A);DL1 A 601 ( 4.9A);DL1 A 601 (-3.9A)","0.69A","2y7jD-6bfnA:24.1","2y7jB-6bfnA:13.20"],["3BBT_D_FMMD91_1","RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",7,"VAL A 226;ALA A 237;LEU A 286;GLY A 294;LEU A 347;ASP A 358;PHE A 359","None;DL1 A 601 (-3.4A);None;DL1 A 601 (-3.5A);DL1 A 601 (-3.9A);DL1 A 601 (-3.1A);None","0.86A","3bbtD-6bfnA:23.4","2y7jD-6bfnA:13.20"],["3MIY_A_B49A1_1","TYROSINE-PROTEIN KINASE ITK\/TSK","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",8,"ILE A 218;ALA A 237;LYS A 239;VAL A 272;PHE A 290;GLY A 294;LEU A 347;ASP A 358","DL1 A 601 (-4.0A);DL1 A 601 (-3.4A);DL1 A 601 ( 4.1A);DL1 A 601 ( 4.8A);DL1 A 601 (-4.3A);DL1 A 601 (-3.5A);DL1 A 601 (-3.9A);DL1 A 601 (-3.1A)","0.61A","3miyA-6bfnA:25.0","3bbtD-6bfnA:17.75"],["3MIY_B_B49B2_1","TYROSINE-PROTEIN KINASE ITK\/TSK","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"ILE A 218;ALA A 237;LYS A 239;PHE A 290;GLY A 294;LEU A 347","DL1 A 601 (-4.0A);DL1 A 601 (-3.4A);DL1 A 601 ( 4.1A);DL1 A 601 (-4.3A);DL1 A 601 (-3.5A);DL1 A 601 (-3.9A)","0.57A","3miyB-6bfnA:24.8","3miyA-6bfnA:15.81"],["3OG7_A_032A1_1","AKAP9-BRAF FUSION PROTEIN","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"ILE A 218;VAL A 226;ALA A 237;LYS A 239;LEU A 263;PHE A 359","DL1 A 601 (-4.0A);None;DL1 A 601 (-3.4A);DL1 A 601 ( 4.1A);None;None","1.27A","3og7A-6bfnA:24.6","3miyB-6bfnA:15.81"],["4I22_A_IREA9001_1","EPIDERMAL GROWTH FACTOR RECEPTOR","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",8,"GLY A 219;VAL A 226;ALA A 237;LEU A 286;GLY A 294;ASP A 298;LEU A 347;ASP A 358","DL1 A 601 ( 4.1A);None;DL1 A 601 (-3.4A);None;DL1 A 601 (-3.5A);DL1 A 601 ( 4.9A);DL1 A 601 (-3.9A);DL1 A 601 (-3.1A)","0.80A","4i22A-6bfnA:23.0","3og7A-6bfnA:13.75"],["4KS8_A_B49A701_1","SERINE\/THREONINE-PROTEIN KINASE PAK 6","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",8,"ILE A 218;ALA A 237;VAL A 272;PHE A 290;LEU A 291;GLY A 294;LEU A 347;ASP A 358","DL1 A 601 (-4.0A);DL1 A 601 (-3.4A);DL1 A 601 ( 4.8A);DL1 A 601 (-4.3A);DL1 A 601 (-4.4A);DL1 A 601 (-3.5A);DL1 A 601 (-3.9A);DL1 A 601 (-3.1A)","0.56A","4ks8A-6bfnA:24.7","4i22A-6bfnA:13.20"],["4OTI_A_MI1A1001_1","SERINE\/THREONINE-PROTEIN KINASE N1","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",8,"GLY A 219;GLY A 221;GLY A 224;VAL A 226;ALA A 237;LYS A 239;VAL A 272;ASP A 358","DL1 A 601 ( 4.1A);None;None;None;DL1 A 601 (-3.4A);DL1 A 601 ( 4.1A);DL1 A 601 ( 4.8A);DL1 A 601 (-3.1A)","0.82A","4otiA-6bfnA:17.1","4ks8A-6bfnA:14.81"],["4QMZ_A_B49A401_1","SERINE\/THREONINE-PROTEIN KINASE 24","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"ILE A 218;GLY A 219;VAL A 226;ALA A 237;LEU A 291;LEU A 347","DL1 A 601 (-4.0A);DL1 A 601 ( 4.1A);None;DL1 A 601 (-3.4A);DL1 A 601 (-4.4A);DL1 A 601 (-3.9A)","0.49A","4qmzA-6bfnA:24.0","4otiA-6bfnA:15.38"],["4RZV_B_032B801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"VAL A 226;ALA A 237;LYS A 239;SER A 295;GLY A 357;GLY A 360","None;DL1 A 601 (-3.4A);DL1 A 601 ( 4.1A);DL1 A 601 ( 4.6A);DL1 A 601 ( 4.8A);None","1.10A","4rzvB-6bfnA:24.6","4qmzA-6bfnA:14.42"],["4XV2_A_P06A801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"VAL A 226;ALA A 237;LYS A 239;GLY A 357;ASP A 358;PHE A 359","None;DL1 A 601 (-3.4A);DL1 A 601 ( 4.1A);DL1 A 601 ( 4.8A);DL1 A 601 (-3.1A);None","1.01A","4xv2A-6bfnA:24.4","4rzvB-6bfnA:15.30"],["4XV2_B_P06B801_1","SERINE\/THREONINE-PROTEIN KINASE B-RAF","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",5,"ALA A 237;LYS A 239;GLY A 357;ASP A 358;PHE A 359","DL1 A 601 (-3.4A);DL1 A 601 ( 4.1A);DL1 A 601 ( 4.8A);DL1 A 601 (-3.1A);None","0.96A","4xv2B-6bfnA:24.8","4xv2A-6bfnA:14.93"],["5H2U_C_1N1C501_1","PROTEIN-TYROSINE KINASE 6","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",5,"ALA A 237;GLY A 294;LEU A 347;GLY A 357;ASP A 358","DL1 A 601 (-3.4A);DL1 A 601 (-3.5A);DL1 A 601 (-3.9A);DL1 A 601 ( 4.8A);DL1 A 601 (-3.1A)","0.57A","5h2uC-6bfnA:24.1","4xv2B-6bfnA:14.93"],["5H2U_D_1N1D504_1","PROTEIN-TYROSINE KINASE 6","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"VAL A 226;ALA A 237;GLY A 294;LEU A 347;GLY A 357;ASP A 358","None;DL1 A 601 (-3.4A);DL1 A 601 (-3.5A);DL1 A 601 (-3.9A);DL1 A 601 ( 4.8A);DL1 A 601 (-3.1A)","0.59A","5h2uD-6bfnA:24.2","5h2uC-6bfnA:14.61"],["5IZJ_G_AZ1G2_1","CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA;47P-AZ1-DAR-DAR","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",5,"GLY A 219;GLY A 221;VAL A 226;LYS A 239;LEU A 241","DL1 A 601 ( 4.1A);None;None;DL1 A 601 ( 4.1A);None","0.69A","5izjA-6bfnA:20.4","5h2uD-6bfnA:14.61"],["5NNW_D_GCSD302_1","25 KDA PROTEIN ELICITOR","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",4,"ASP A 340;GLY A 339;HIS A 338;ASP A 358","None;None;None;DL1 A 601 (-3.1A)","1.06A","5nnwD-6bfnA:undetectable","5izjA-6bfnA:11.46"],["5NO9_D_95ZD302_1","25 KDA PROTEIN ELICITOR","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",4,"ASP A 340;GLY A 339;HIS A 338;ASP A 358","None;None;None;DL1 A 601 (-3.1A)","1.05A","5no9D-6bfnA:undetectable","5nnwD-6bfnA:21.43"],["5VC3_A_DB8A601_1","WEE1-LIKE PROTEIN KINASE","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"ILE A 218;GLY A 219;ALA A 237;GLU A 259;GLY A 294;ASP A 298","DL1 A 601 (-4.0A);DL1 A 601 ( 4.1A);DL1 A 601 (-3.4A);None;DL1 A 601 (-3.5A);DL1 A 601 ( 4.9A)","0.58A","5vc3A-6bfnA:24.7","5no9D-6bfnA:21.43"],["5VOO_E_C2FE3001_0","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",5,"GLY A 222;VAL A 272;LEU A 356;GLY A 360;SER A 255","None;DL1 A 601 ( 4.8A);None;None;None","1.13A","5vooE-6bfnA:undetectable","5vc3A-6bfnA:13.00"],["5VOO_F_C2FF3001_0","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",5,"GLY A 222;VAL A 272;LEU A 356;GLY A 360;SER A 255","None;DL1 A 601 ( 4.8A);None;None;None","1.14A","5vooF-6bfnA:undetectable","5vooE-6bfnA:undetectable"],["5VOP_B_C2FB3001_0","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",5,"GLY A 222;VAL A 272;LEU A 356;GLY A 360;SER A 255","None;DL1 A 601 ( 4.8A);None;None;None","1.17A","5vopB-6bfnA:undetectable","5vooF-6bfnA:undetectable"],["5YU9_A_1E8A1101_1","EPIDERMAL GROWTH FACTOR RECEPTOR","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"GLY A 219;VAL A 226;ALA A 237;LEU A 286;LEU A 347;ASP A 358","DL1 A 601 ( 4.1A);None;DL1 A 601 (-3.4A);None;DL1 A 601 (-3.9A);DL1 A 601 (-3.1A)","0.63A","5yu9A-6bfnA:22.9","5vopB-6bfnA:undetectable"],["5YU9_B_1E8B1101_1","EPIDERMAL GROWTH FACTOR RECEPTOR","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",6,"GLY A 219;VAL A 226;ALA A 237;LEU A 286;LEU A 347;ASP A 358","DL1 A 601 ( 4.1A);None;DL1 A 601 (-3.4A);None;DL1 A 601 (-3.9A);DL1 A 601 (-3.1A)","0.60A","5yu9B-6bfnA:22.9","5yu9A-6bfnA:29.07"],["5YU9_C_1E8C1101_1","EPIDERMAL GROWTH FACTOR RECEPTOR","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",5,"VAL A 226;ALA A 237;LEU A 286;GLY A 294;ASP A 358","None;DL1 A 601 (-3.4A);None;DL1 A 601 (-3.5A);DL1 A 601 (-3.1A)","0.48A","5yu9C-6bfnA:22.6","5yu9B-6bfnA:29.07"],["5YU9_D_1E8D1101_1","EPIDERMAL GROWTH FACTOR RECEPTOR","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",5,"VAL A 226;ALA A 237;GLY A 294;LEU A 347;ASP A 358","None;DL1 A 601 (-3.4A);DL1 A 601 (-3.5A);DL1 A 601 (-3.9A);DL1 A 601 (-3.1A)","0.49A","5yu9D-6bfnA:23.1","5yu9C-6bfnA:29.07"],["6DJZ_B_GMJB301_0","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",5,"LEU A 241;HIS A 338;VAL A 272;THR A 258;LEU A 257","None;None;DL1 A 601 ( 4.8A);None;None","1.27A","6djzB-6bfnA:undetectable","5yu9D-6bfnA:29.07"],["6FNM_A_1N1A1001_1","-","6bfn","INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1","Homo sapiens",7,"ILE A 218;VAL A 226;ALA A 237;LYS A 239;GLU A 259;GLY A 294;LEU A 347","DL1 A 601 (-4.0A);None;DL1 A 601 (-3.4A);DL1 A 601 ( 4.1A);None;DL1 A 601 (-3.5A);DL1 A 601 (-3.9A)","0.82A","6fnmA-6bfnA:24.4","6djzB-6bfnA:undetectable"]]