SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'DIF'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_A_CHDA1501_0 (FERROCHELATASE)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	LEU A 154 LEU A 151 ILE A 139 LEU A 369 VAL A 67	None None DIF A1374 (-4.7A) None None	1.00A	1hrkA-2wekA: 2.8	1hrkA-2wekA: 23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBI_B_SAMB1293_0 (GLYCINE N-METHYLTRANSFERASE)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	GLY A 270 ALA A 76 SER A 77 GLY A 250 SER A 273	NAP A1372 (-3.3A) NAP A1372 (-3.6A) DIF A1373 (-3.0A) None NAP A1372 (-4.8A)	1.16A	1nbiB-2wekA: 7.9	1nbiB-2wekA: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBI_C_SAMC2293_0 (GLYCINE N-METHYLTRANSFERASE)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	GLY A 270 ALA A 76 SER A 77 GLY A 250 SER A 273	NAP A1372 (-3.3A) NAP A1372 (-3.6A) DIF A1373 (-3.0A) None NAP A1372 (-4.8A)	1.20A	1nbiC-2wekA: 7.9	1nbiC-2wekA: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBI_D_SAMD3293_0 (GLYCINE N-METHYLTRANSFERASE)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	GLY A 270 ALA A 76 SER A 77 GLY A 250 SER A 273	NAP A1372 (-3.3A) NAP A1372 (-3.6A) DIF A1373 (-3.0A) None NAP A1372 (-4.8A)	1.20A	1nbiD-2wekA: 7.9	1nbiD-2wekA: 22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1OG5_A_SWFA502_1 (CYTOCHROME P450 2C9)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	ARG A 97 LEU A 208 PHE A 114 THR A 361 LEU A 363 PRO A 364	HEM A 500 (-2.6A) None DIF A 501 (-4.5A) None HEM A 500 (-4.0A) None	1.14A	1og5A-1nr6A: 55.1	1og5A-1nr6A: 77.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1R9O_A_FLPA501_1 (CYTOCHROME P450 2C9)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	ASN A 204 ASP A 290 GLY A 293 ALA A 294 THR A 298 LEU A 363	None None DIF A 501 (-3.8A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) HEM A 500 (-4.0A)	0.55A	1r9oA-1nr6A: 53.3	1r9oA-1nr6A: 76.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HRC_A_CHDA701_0 (FERROCHELATASE)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	LEU A 154 LEU A 151 ILE A 139 LEU A 369 VAL A 67	None None DIF A1374 (-4.7A) None None	0.95A	2hrcA-2wekA: undetectable	2hrcA-2wekA: 23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HRC_B_CHDB1605_0 (FERROCHELATASE)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	LEU A 154 LEU A 151 ILE A 139 LEU A 369 VAL A 67	None None DIF A1374 (-4.7A) None None	0.97A	2hrcB-2wekA: 2.3	2hrcB-2wekA: 23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO5_A_CHDA501_0 (FERROCHELATASE, MITOCHONDRIAL)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	LEU A 154 LEU A 151 ILE A 139 LEU A 369 VAL A 67	None None DIF A1374 (-4.7A) None None	0.99A	2po5A-2wekA: 3.3	2po5A-2wekA: 23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO7_A_CHDA501_0 (FERROCHELATASE, MITOCHONDRIAL)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	LEU A 154 LEU A 151 ILE A 139 LEU A 369 VAL A 67	None None DIF A1374 (-4.7A) None None	0.96A	2po7A-2wekA: 2.3	2po7A-2wekA: 23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3B_B_FOLB401_1 (DIHYDROFOLATE REDUCTASE)	4ubs	PENTALENIC ACID SYNTHASE (Streptomyces avermitilis)	3 / 3	GLU A 83 GLN A 187 ARG A 190	PEG A 516 (-4.1A) PEG A 513 ( 4.6A) DIF A 502 ( 4.7A)	0.97A	2w3bB-4ubsA: undetectable	2w3bB-4ubsA: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WUZ_A_TPFA1460_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE , PUTATIVE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	5 / 10	PHE A 114 ALA A 294 THR A 298 LEU A 359 VAL A 474	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) DIF A 501 (-4.4A) None	0.94A	2wuzA-1nr6A: 33.7	2wuzA-1nr6A: 26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WUZ_B_TPFB1460_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE , PUTATIVE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	5 / 10	PHE A 114 ALA A 294 THR A 298 LEU A 359 VAL A 474	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) DIF A 501 (-4.4A) None	0.93A	2wuzB-1nr6A: 33.6	2wuzB-1nr6A: 26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WX2_A_TPFA1460_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	4 / 7	PHE A 114 ALA A 294 THR A 298 LEU A 359	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) DIF A 501 (-4.4A)	0.86A	2wx2A-1nr6A: 32.1	2wx2A-1nr6A: 26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WX2_B_TPFB1460_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	4 / 8	PHE A 114 ALA A 294 THR A 298 LEU A 359	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) DIF A 501 (-4.4A)	0.81A	2wx2B-1nr6A: 31.5	2wx2B-1nr6A: 26.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X7H_A_PFNA1372_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	6 / 11	TYR A 161 LEU A 164 LEU A 170 LEU A 192 LYS A 195 MET A 322	DIF A1376 (-4.3A) DIF A1376 ( 4.5A) DIF A1376 ( 4.5A) DIF A1376 (-4.4A) None DIF A1376 (-3.6A)	0.15A	2x7hA-2wekA: 59.3 2x7hB-2wekA: 59.2	2x7hA-2wekA: 97.71 2x7hB-2wekA: 97.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X7H_A_PFNA1375_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	4 / 5	SER A 77 PHE A 98 VAL A 155 TYR A 275	DIF A1373 (-3.0A) DIF A1374 ( 3.9A) DIF A1373 (-4.4A) GOL A1380 (-3.4A)	0.22A	2x7hA-2wekA: 59.3	2x7hA-2wekA: 97.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2X7H_B_PFNB1372_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	4 / 5	SER A 77 PHE A 98 VAL A 155 TYR A 275	DIF A1373 (-3.0A) DIF A1374 ( 3.9A) DIF A1373 (-4.4A) GOL A1380 (-3.4A)	0.26A	2x7hB-2wekA: 59.2	2x7hB-2wekA: 97.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y05_A_RALA801_1 (PROSTAGLANDIN REDUCTASE 1)	4ubs	PENTALENIC ACID SYNTHASE (Streptomyces avermitilis)	4 / 8	VAL A 85 ARG A 88 SER A 67 VAL A 90	DIF A 502 (-4.4A) None None PO4 A 523 (-4.4A)	1.31A	2y05A-4ubsA: undetectable 2y05B-4ubsA: undetectable	2y05A-4ubsA: 21.74 2y05B-4ubsA: 21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3E4E_A_4PZA501_1 (CYTOCHROME P450 2E1)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	3 / 3	ALA A 294 THR A 298 CYH A 432	DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) HEM A 500 (-2.3A)	0.47A	3e4eA-1nr6A: 51.4	3e4eA-1nr6A: 57.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3E4E_B_4PZB501_1 (CYTOCHROME P450 2E1)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	3 / 3	ALA A 294 THR A 298 CYH A 432	DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) HEM A 500 (-2.3A)	0.41A	3e4eB-1nr6A: 51.5	3e4eB-1nr6A: 57.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3F8W_A_ADNA300_1 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	GLY A 73 VAL A 72 GLY A 100 ASN A 75 VAL A 155	None None None DIF A1373 (-4.1A) DIF A1373 (-4.4A)	1.19A	3f8wA-2wekA: undetectable	3f8wA-2wekA: 23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3F8W_B_ADNB301_1 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	GLY A 73 VAL A 72 GLY A 100 ASN A 75 VAL A 155	None None None DIF A1373 (-4.1A) DIF A1373 (-4.4A)	1.20A	3f8wB-2wekA: undetectable	3f8wB-2wekA: 23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3F8W_C_ADNC302_1 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	GLY A 73 VAL A 72 GLY A 100 ASN A 75 VAL A 155	None None None DIF A1373 (-4.1A) DIF A1373 (-4.4A)	1.19A	3f8wC-2wekA: undetectable	3f8wC-2wekA: 23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KHM_A_TPFA501_1 (STEROL 14 ALPHA-DEMETHYLASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	4 / 8	PHE A 114 ALA A 294 THR A 298 LEU A 359	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) DIF A 501 (-4.4A)	0.74A	3khmA-1nr6A: 32.7	3khmA-1nr6A: 26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L4D_A_TPFA490_1 (STEROL 14-ALPHA DEMETHYLASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	4 / 8	PHE A 114 ALA A 294 THR A 298 LEU A 359	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) DIF A 501 (-4.4A)	0.78A	3l4dA-1nr6A: 33.3	3l4dA-1nr6A: 27.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L4D_D_TPFD490_1 (STEROL 14-ALPHA DEMETHYLASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	4 / 8	PHE A 114 ALA A 294 THR A 298 LEU A 359	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) DIF A 501 (-4.4A)	0.74A	3l4dD-1nr6A: 32.9	3l4dD-1nr6A: 27.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MDV_B_CL6B506_1 (CHOLESTEROL 24-HYDROXYLASE)	4ubs	PENTALENIC ACID SYNTHASE (Streptomyces avermitilis)	6 / 12	LEU A 178 ILE A 240 ALA A 241 GLU A 244 THR A 245 ALA A 288	None DIF A 502 (-3.3A) HEM A 501 ( 3.8A) None HEM A 501 ( 3.3A) HEM A 501 ( 3.7A)	0.99A	3mdvB-4ubsA: 33.6	3mdvB-4ubsA: 26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXV_C_478C200_1 (HIV-1 PROTEASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	5 / 9	GLY A 293 VAL A 177 GLY A 434 VAL A 433 ILE A 178	DIF A 501 (-3.8A) None HEM A 500 (-3.6A) HEM A 500 ( 4.3A) None	0.92A	3oxvC-1nr6A: undetectable	3oxvC-1nr6A: 11.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3R9C_A_ECLA451_1 (CYTOCHROME P450 164A2)	4ubs	PENTALENIC ACID SYNTHASE (Streptomyces avermitilis)	5 / 10	LEU A 178 LEU A 237 ALA A 241 THR A 245 THR A 391	None DIF A 502 (-4.4A) HEM A 501 ( 3.8A) HEM A 501 ( 3.3A) None	1.21A	3r9cA-4ubsA: 42.5	3r9cA-4ubsA: 32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3R9C_A_ECLA451_1 (CYTOCHROME P450 164A2)	4ubs	PENTALENIC ACID SYNTHASE (Streptomyces avermitilis)	5 / 10	LEU A 237 ILE A 240 ALA A 241 THR A 245 THR A 391	DIF A 502 (-4.4A) DIF A 502 (-3.3A) HEM A 501 ( 3.8A) HEM A 501 ( 3.3A) None	1.01A	3r9cA-4ubsA: 42.5	3r9cA-4ubsA: 32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RUK_A_AERA601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	ALA A 113 PHE A 114 ASP A 290 ALA A 294 THR A 298 CYH A 432	DIF A 501 (-3.6A) DIF A 501 (-4.5A) None DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) HEM A 500 (-2.3A)	0.70A	3rukA-1nr6A: 44.2	3rukA-1nr6A: 32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RUK_A_AERA601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	ALA A 113 PHE A 114 ASP A 290 ALA A 294 THR A 298 VAL A 474	DIF A 501 (-3.6A) DIF A 501 (-4.5A) None DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) None	1.23A	3rukA-1nr6A: 44.2	3rukA-1nr6A: 32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RUK_B_AERB601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	ALA A 113 PHE A 114 ASP A 290 GLY A 293 ALA A 294 THR A 298	DIF A 501 (-3.6A) DIF A 501 (-4.5A) None DIF A 501 (-3.8A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A)	0.76A	3rukB-1nr6A: 44.1	3rukB-1nr6A: 32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RUK_D_AERD601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	7 / 11	ALA A 113 PHE A 114 ASP A 290 GLY A 293 ALA A 294 THR A 298 VAL A 474	DIF A 501 (-3.6A) DIF A 501 (-4.5A) None DIF A 501 (-3.8A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) None	1.38A	3rukD-1nr6A: 43.4	3rukD-1nr6A: 32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3T3S_D_9PLD1_1 (CYTOCHROME P450 2A13)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	4 / 8	ALA A 113 PHE A 114 ALA A 294 THR A 298	DIF A 501 (-3.6A) DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A)	0.78A	3t3sD-1nr6A: 49.4	3t3sD-1nr6A: 54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3T3Z_A_9PLA501_1 (CYTOCHROME P450 2E1)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	4 / 6	PHE A 114 ALA A 294 THR A 298 LEU A 363	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) HEM A 500 (-4.0A)	0.70A	3t3zA-1nr6A: 50.9	3t3zA-1nr6A: 57.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3T3Z_B_9PLB501_1 (CYTOCHROME P450 2E1)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	4 / 6	PHE A 114 ALA A 294 THR A 298 LEU A 363	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) HEM A 500 (-4.0A)	0.69A	3t3zB-1nr6A: 50.7	3t3zB-1nr6A: 57.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3T3Z_C_9PLC501_1 (CYTOCHROME P450 2E1)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	4 / 5	PHE A 114 ALA A 294 THR A 298 LEU A 363	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) HEM A 500 (-4.0A)	0.73A	3t3zC-1nr6A: 50.7	3t3zC-1nr6A: 57.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3T3Z_D_9PLD501_1 (CYTOCHROME P450 2E1)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	4 / 6	PHE A 114 ALA A 294 THR A 298 LEU A 363	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) HEM A 500 (-4.0A)	0.70A	3t3zD-1nr6A: 50.7	3t3zD-1nr6A: 57.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AC9_C_DXCC1477_0 (MJ0495-LIKE PROTEIN)	4ubs	PENTALENIC ACID SYNTHASE (Streptomyces avermitilis)	4 / 6	GLY A 242 ARG A 175 ILE A 240 LEU A 160	HEM A 501 (-3.6A) PGE A 506 (-4.0A) DIF A 502 (-3.3A) None	1.12A	4ac9C-4ubsA: undetectable	4ac9C-4ubsA: 20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACA_C_DXCC1477_0 (TRANSLATION ELONGATION FACTOR SELB)	4ubs	PENTALENIC ACID SYNTHASE (Streptomyces avermitilis)	4 / 6	GLY A 242 ARG A 175 ILE A 240 LEU A 160	HEM A 501 (-3.6A) PGE A 506 (-4.0A) DIF A 502 (-3.3A) None	1.16A	4acaC-4ubsA: undetectable	4acaC-4ubsA: 20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EJG_B_NCTB501_1 (CYTOCHROME P450 2A13)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	4 / 8	PHE A 114 ALA A 294 THR A 298 LEU A 359	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) DIF A 501 (-4.4A)	0.82A	4ejgB-1nr6A: 50.0	4ejgB-1nr6A: 54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EJG_D_NCTD501_1 (CYTOCHROME P450 2A13)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	4 / 6	PHE A 114 ALA A 294 THR A 298 LEU A 359	DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) DIF A 501 (-4.4A)	0.81A	4ejgD-1nr6A: 50.1	4ejgD-1nr6A: 54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4NKV_A_AERA601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	5 / 12	LEU A 103 ALA A 113 GLY A 293 ALA A 294 THR A 298	DIF A 501 (-3.9A) DIF A 501 (-3.6A) DIF A 501 (-3.8A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A)	1.02A	4nkvA-1nr6A: 44.1	4nkvA-1nr6A: 32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4NKV_C_AERC601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	5 / 12	LEU A 103 ALA A 113 PHE A 114 ALA A 294 THR A 298	DIF A 501 (-3.9A) DIF A 501 (-3.6A) DIF A 501 (-4.5A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A)	1.15A	4nkvC-1nr6A: 44.0	4nkvC-1nr6A: 32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4NKX_A_STRA601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	LEU A 103 ALA A 113 PHE A 114 GLY A 293 ALA A 294 THR A 298	DIF A 501 (-3.9A) DIF A 501 (-3.6A) DIF A 501 (-4.5A) DIF A 501 (-3.8A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A)	1.13A	4nkxA-1nr6A: 44.1	4nkxA-1nr6A: 32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4NKX_B_STRB601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	LEU A 103 ALA A 113 PHE A 114 GLY A 293 ALA A 294 THR A 298	DIF A 501 (-3.9A) DIF A 501 (-3.6A) DIF A 501 (-4.5A) DIF A 501 (-3.8A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A)	1.12A	4nkxB-1nr6A: 44.1	4nkxB-1nr6A: 32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4NKX_C_STRC601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	LEU A 103 ALA A 113 PHE A 114 GLY A 293 ALA A 294 THR A 298	DIF A 501 (-3.9A) DIF A 501 (-3.6A) DIF A 501 (-4.5A) DIF A 501 (-3.8A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A)	1.07A	4nkxC-1nr6A: 44.0	4nkxC-1nr6A: 32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4NKX_D_STRD601_1 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	LEU A 103 ALA A 113 PHE A 114 GLY A 293 ALA A 294 THR A 298	DIF A 501 (-3.9A) DIF A 501 (-3.6A) DIF A 501 (-4.5A) DIF A 501 (-3.8A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A)	1.11A	4nkxD-1nr6A: 44.1	4nkxD-1nr6A: 32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4R1Z_A_AERA601_1 (CYP17A1 PROTEIN)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	5 / 9	ALA A 113 ASP A 290 GLY A 293 ALA A 294 THR A 298	DIF A 501 (-3.6A) None DIF A 501 (-3.8A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A)	0.95A	4r1zA-1nr6A: 44.1	4r1zA-1nr6A: 32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4R20_B_AERB602_1 (CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	5 / 9	ALA A 113 PHE A 114 ILE A 240 THR A 298 VAL A 205	DIF A 501 (-3.6A) DIF A 501 (-4.5A) None HEM A 500 ( 3.6A) None	1.23A	4r20B-1nr6A: 43.5	4r20B-1nr6A: 35.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZF8_A_MYTA502_1 (BIFUNCTIONAL P-450/NADPH-P450 REDUCTASE)	4ubs	PENTALENIC ACID SYNTHASE (Streptomyces avermitilis)	4 / 6	LEU A 178 ILE A 240 ALA A 241 ALA A 288	None DIF A 502 (-3.3A) HEM A 501 ( 3.8A) HEM A 501 ( 3.7A)	0.63A	4zf8A-4ubsA: 31.8	4zf8A-4ubsA: 24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GWX_A_SAMA301_0 (GLYCINE SARCOSINE N-METHYLTRANSFERASE)	2wek	ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	GLY A 270 PHE A 303 GLY A 274 SER A 273 SER A 77	NAP A1372 (-3.3A) NAP A1372 (-4.9A) None NAP A1372 (-4.8A) DIF A1373 (-3.0A)	1.05A	5gwxA-2wekA: 7.6	5gwxA-2wekA: 20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TL8_A_X2NA502_1 (PROTEIN CYP51)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	ALA A 47 PHE A 114 ALA A 113 ALA A 294 THR A 298 LEU A 359	None DIF A 501 (-4.5A) DIF A 501 (-3.6A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) DIF A 501 (-4.4A)	1.38A	5tl8A-1nr6A: 34.9	5tl8A-1nr6A: 28.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5X23_A_LSNA502_1 (CYTOCHROME P450 2C9)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	5 / 12	PHE A 114 GLY A 293 ALA A 294 LEU A 359 LEU A 363	DIF A 501 (-4.5A) DIF A 501 (-3.8A) DIF A 501 ( 3.3A) DIF A 501 (-4.4A) HEM A 500 (-4.0A)	0.58A	5x23A-1nr6A: 55.6	5x23A-1nr6A: 76.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5X24_A_LSNA502_1 (CYTOCHROME P450 2C9)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	ASN A 204 LEU A 233 ASP A 290 GLY A 293 THR A 298 LEU A 363	None None None DIF A 501 (-3.8A) HEM A 500 ( 3.6A) HEM A 500 (-4.0A)	0.86A	5x24A-1nr6A: 55.2	5x24A-1nr6A: 76.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5X24_A_LSNA502_1 (CYTOCHROME P450 2C9)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	5 / 12	PHE A 114 LEU A 233 ASP A 290 THR A 298 LEU A 363	DIF A 501 (-4.5A) None None HEM A 500 ( 3.6A) HEM A 500 (-4.0A)	0.84A	5x24A-1nr6A: 55.2	5x24A-1nr6A: 76.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XXI_A_LSNA501_1 (CYTOCHROME P450 2C9)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	ASN A 204 ASP A 290 GLY A 293 ALA A 294 LEU A 359 LEU A 363	None None DIF A 501 (-3.8A) DIF A 501 ( 3.3A) DIF A 501 (-4.4A) HEM A 500 (-4.0A)	0.61A	5xxiA-1nr6A: 55.4	5xxiA-1nr6A: 76.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XXI_A_LSNA503_1 (CYTOCHROME P450 2C9)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	5 / 12	PHE A 114 LEU A 359 PRO A 360 THR A 361 PRO A 364	DIF A 501 (-4.5A) DIF A 501 (-4.4A) None None None	0.67A	5xxiA-1nr6A: 55.4	5xxiA-1nr6A: 76.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A7J_A_TESA502_0 (CYTOCHROME P450)	4ubs	PENTALENIC ACID SYNTHASE (Streptomyces avermitilis)	4 / 7	LEU A 93 LEU A 237 ALA A 241 THR A 245	HEM A 501 ( 4.1A) DIF A 502 (-4.4A) HEM A 501 ( 3.8A) HEM A 501 ( 3.3A)	0.68A	6a7jA-4ubsA: 29.8	6a7jA-4ubsA: 14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AYC_A_1YNA502_1 (PROTEIN CYP51)	1nr6	CYTOCHROME P450 2C5 (Oryctolagus cuniculus)	6 / 12	ALA A 47 PHE A 114 ALA A 113 ALA A 294 THR A 298 LEU A 359	None DIF A 501 (-4.5A) DIF A 501 (-3.6A) DIF A 501 ( 3.3A) HEM A 500 ( 3.6A) DIF A 501 (-4.4A)	1.45A	6aycA-1nr6A: 35.2	6aycA-1nr6A: 11.66

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HRK_A_CHDA1501_0","FERROCHELATASE","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"LEU A 154;LEU A 151;ILE A 139;LEU A 369;VAL A  67","None;None;DIF A1374 (-4.7A);None;None","1.00A","1hrkA-2wekA:2.8",null],["1NBI_B_SAMB1293_0","GLYCINE N-METHYLTRANSFERASE","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"GLY A 270;ALA A  76;SER A  77;GLY A 250;SER A 273","NAP A1372 (-3.3A);NAP A1372 (-3.6A);DIF A1373 (-3.0A);None;NAP A1372 (-4.8A)","1.16A","1nbiB-2wekA:7.9","1hrkA-2wekA:23.74"],["1NBI_C_SAMC2293_0","GLYCINE N-METHYLTRANSFERASE","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"GLY A 270;ALA A  76;SER A  77;GLY A 250;SER A 273","NAP A1372 (-3.3A);NAP A1372 (-3.6A);DIF A1373 (-3.0A);None;NAP A1372 (-4.8A)","1.20A","1nbiC-2wekA:7.9","1nbiB-2wekA:22.31"],["1NBI_D_SAMD3293_0","GLYCINE N-METHYLTRANSFERASE","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"GLY A 270;ALA A  76;SER A  77;GLY A 250;SER A 273","NAP A1372 (-3.3A);NAP A1372 (-3.6A);DIF A1373 (-3.0A);None;NAP A1372 (-4.8A)","1.20A","1nbiD-2wekA:7.9","1nbiC-2wekA:22.31"],["1OG5_A_SWFA502_1","CYTOCHROME P450 2C9","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"ARG A  97;LEU A 208;PHE A 114;THR A 361;LEU A 363;PRO A 364","HEM A 500 (-2.6A);None;DIF A 501 (-4.5A);None;HEM A 500 (-4.0A);None","1.14A","1og5A-1nr6A:55.1","1nbiD-2wekA:22.31"],["1R9O_A_FLPA501_1","CYTOCHROME P450 2C9","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"ASN A 204;ASP A 290;GLY A 293;ALA A 294;THR A 298;LEU A 363","None;None;DIF A 501 (-3.8A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);HEM A 500 (-4.0A)","0.55A","1r9oA-1nr6A:53.3","1og5A-1nr6A:77.73"],["2HRC_A_CHDA701_0","FERROCHELATASE","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"LEU A 154;LEU A 151;ILE A 139;LEU A 369;VAL A  67","None;None;DIF A1374 (-4.7A);None;None","0.95A","2hrcA-2wekA:undetectable","1r9oA-1nr6A:76.52"],["2HRC_B_CHDB1605_0","FERROCHELATASE","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"LEU A 154;LEU A 151;ILE A 139;LEU A 369;VAL A  67","None;None;DIF A1374 (-4.7A);None;None","0.97A","2hrcB-2wekA:2.3","2hrcA-2wekA:23.74"],["2PO5_A_CHDA501_0","FERROCHELATASE, MITOCHONDRIAL","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"LEU A 154;LEU A 151;ILE A 139;LEU A 369;VAL A  67","None;None;DIF A1374 (-4.7A);None;None","0.99A","2po5A-2wekA:3.3","2hrcB-2wekA:23.74"],["2PO7_A_CHDA501_0","FERROCHELATASE, MITOCHONDRIAL","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"LEU A 154;LEU A 151;ILE A 139;LEU A 369;VAL A  67","None;None;DIF A1374 (-4.7A);None;None","0.96A","2po7A-2wekA:2.3","2po5A-2wekA:23.74"],["2W3B_B_FOLB401_1","DIHYDROFOLATE REDUCTASE","4ubs","PENTALENIC ACID SYNTHASE","Streptomyces avermitilis",3,"GLU A  83;GLN A 187;ARG A 190","PEG A 516 (-4.1A);PEG A 513 ( 4.6A);DIF A 502 ( 4.7A)","0.97A","2w3bB-4ubsA:undetectable","2po7A-2wekA:23.74"],["2WUZ_A_TPFA1460_1","LANOSTEROL 14-ALPHA-DEMETHYLASE, PUTATIVE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",5,"PHE A 114;ALA A 294;THR A 298;LEU A 359;VAL A 474","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);DIF A 501 (-4.4A);None","0.94A","2wuzA-1nr6A:33.7","2w3bB-4ubsA:18.16"],["2WUZ_B_TPFB1460_1","LANOSTEROL 14-ALPHA-DEMETHYLASE, PUTATIVE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",5,"PHE A 114;ALA A 294;THR A 298;LEU A 359;VAL A 474","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);DIF A 501 (-4.4A);None","0.93A","2wuzB-1nr6A:33.6","2wuzA-1nr6A:26.09"],["2WX2_A_TPFA1460_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",4,"PHE A 114;ALA A 294;THR A 298;LEU A 359","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);DIF A 501 (-4.4A)","0.86A","2wx2A-1nr6A:32.1","2wuzB-1nr6A:26.09"],["2WX2_B_TPFB1460_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",4,"PHE A 114;ALA A 294;THR A 298;LEU A 359","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);DIF A 501 (-4.4A)","0.81A","2wx2B-1nr6A:31.5","2wx2A-1nr6A:26.09"],["2X7H_A_PFNA1372_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2;ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",6,"TYR A 161;LEU A 164;LEU A 170;LEU A 192;LYS A 195;MET A 322","DIF A1376 (-4.3A);DIF A1376 ( 4.5A);DIF A1376 ( 4.5A);DIF A1376 (-4.4A);None;DIF A1376 (-3.6A)","0.15A","2x7hA-2wekA:59.3;2x7hB-2wekA:59.2","2wx2B-1nr6A:26.09"],["2X7H_A_PFNA1375_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",4,"SER A  77;PHE A  98;VAL A 155;TYR A 275","DIF A1373 (-3.0A);DIF A1374 ( 3.9A);DIF A1373 (-4.4A);GOL A1380 (-3.4A)","0.22A","2x7hA-2wekA:59.3","2x7hA-2wekA:97.71;2x7hB-2wekA:97.71"],["2X7H_B_PFNB1372_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",4,"SER A  77;PHE A  98;VAL A 155;TYR A 275","DIF A1373 (-3.0A);DIF A1374 ( 3.9A);DIF A1373 (-4.4A);GOL A1380 (-3.4A)","0.26A","2x7hB-2wekA:59.2","2x7hA-2wekA:97.71"],["2Y05_A_RALA801_1","PROSTAGLANDIN REDUCTASE 1;PROSTAGLANDIN REDUCTASE 1","4ubs","PENTALENIC ACID SYNTHASE","Streptomyces avermitilis",4,"VAL A  85;ARG A  88;SER A  67;VAL A  90","DIF A 502 (-4.4A);None;None;PO4 A 523 (-4.4A)","1.31A","2y05A-4ubsA:undetectable;2y05B-4ubsA:undetectable","2x7hB-2wekA:97.71"],["3E4E_A_4PZA501_1","CYTOCHROME P450 2E1","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",3,"ALA A 294;THR A 298;CYH A 432","DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);HEM A 500 (-2.3A)","0.47A","3e4eA-1nr6A:51.4","2y05A-4ubsA:21.74;2y05B-4ubsA:21.74"],["3E4E_B_4PZB501_1","CYTOCHROME P450 2E1","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",3,"ALA A 294;THR A 298;CYH A 432","DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);HEM A 500 (-2.3A)","0.41A","3e4eB-1nr6A:51.5","3e4eA-1nr6A:57.65"],["3F8W_A_ADNA300_1","PURINE-NUCLEOSIDE PHOSPHORYLASE","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"GLY A  73;VAL A  72;GLY A 100;ASN A  75;VAL A 155","None;None;None;DIF A1373 (-4.1A);DIF A1373 (-4.4A)","1.19A","3f8wA-2wekA:undetectable","3e4eB-1nr6A:57.65"],["3F8W_B_ADNB301_1","PURINE-NUCLEOSIDE PHOSPHORYLASE","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"GLY A  73;VAL A  72;GLY A 100;ASN A  75;VAL A 155","None;None;None;DIF A1373 (-4.1A);DIF A1373 (-4.4A)","1.20A","3f8wB-2wekA:undetectable","3f8wA-2wekA:23.68"],["3F8W_C_ADNC302_1","PURINE-NUCLEOSIDE PHOSPHORYLASE","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"GLY A  73;VAL A  72;GLY A 100;ASN A  75;VAL A 155","None;None;None;DIF A1373 (-4.1A);DIF A1373 (-4.4A)","1.19A","3f8wC-2wekA:undetectable","3f8wB-2wekA:23.68"],["3KHM_A_TPFA501_1","STEROL 14 ALPHA-DEMETHYLASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",4,"PHE A 114;ALA A 294;THR A 298;LEU A 359","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);DIF A 501 (-4.4A)","0.74A","3khmA-1nr6A:32.7","3f8wC-2wekA:23.68"],["3L4D_A_TPFA490_1","STEROL 14-ALPHA DEMETHYLASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",4,"PHE A 114;ALA A 294;THR A 298;LEU A 359","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);DIF A 501 (-4.4A)","0.78A","3l4dA-1nr6A:33.3","3khmA-1nr6A:26.96"],["3L4D_D_TPFD490_1","STEROL 14-ALPHA DEMETHYLASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",4,"PHE A 114;ALA A 294;THR A 298;LEU A 359","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);DIF A 501 (-4.4A)","0.74A","3l4dD-1nr6A:32.9","3l4dA-1nr6A:27.77"],["3MDV_B_CL6B506_1","CHOLESTEROL 24-HYDROXYLASE","4ubs","PENTALENIC ACID SYNTHASE","Streptomyces avermitilis",6,"LEU A 178;ILE A 240;ALA A 241;GLU A 244;THR A 245;ALA A 288","None;DIF A 502 (-3.3A);HEM A 501 ( 3.8A);None;HEM A 501 ( 3.3A);HEM A 501 ( 3.7A)","0.99A","3mdvB-4ubsA:33.6","3l4dD-1nr6A:27.77"],["3OXV_C_478C200_1","HIV-1 PROTEASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",5,"GLY A 293;VAL A 177;GLY A 434;VAL A 433;ILE A 178","DIF A 501 (-3.8A);None;HEM A 500 (-3.6A);HEM A 500 ( 4.3A);None","0.92A","3oxvC-1nr6A:undetectable","3mdvB-4ubsA:26.87"],["3R9C_A_ECLA451_1","CYTOCHROME P450 164A2","4ubs","PENTALENIC ACID SYNTHASE","Streptomyces avermitilis",5,"LEU A 178;LEU A 237;ALA A 241;THR A 245;THR A 391","None;DIF A 502 (-4.4A);HEM A 501 ( 3.8A);HEM A 501 ( 3.3A);None","1.21A","3r9cA-4ubsA:42.5","3oxvC-1nr6A:11.87"],["3R9C_A_ECLA451_1","CYTOCHROME P450 164A2","4ubs","PENTALENIC ACID SYNTHASE","Streptomyces avermitilis",5,"LEU A 237;ILE A 240;ALA A 241;THR A 245;THR A 391","DIF A 502 (-4.4A);DIF A 502 (-3.3A);HEM A 501 ( 3.8A);HEM A 501 ( 3.3A);None","1.01A","3r9cA-4ubsA:42.5","3r9cA-4ubsA:32.94"],["3RUK_A_AERA601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"ALA A 113;PHE A 114;ASP A 290;ALA A 294;THR A 298;CYH A 432","DIF A 501 (-3.6A);DIF A 501 (-4.5A);None;DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);HEM A 500 (-2.3A)","0.70A","3rukA-1nr6A:44.2","3r9cA-4ubsA:32.94"],["3RUK_A_AERA601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"ALA A 113;PHE A 114;ASP A 290;ALA A 294;THR A 298;VAL A 474","DIF A 501 (-3.6A);DIF A 501 (-4.5A);None;DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);None","1.23A","3rukA-1nr6A:44.2","3rukA-1nr6A:32.81"],["3RUK_B_AERB601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"ALA A 113;PHE A 114;ASP A 290;GLY A 293;ALA A 294;THR A 298","DIF A 501 (-3.6A);DIF A 501 (-4.5A);None;DIF A 501 (-3.8A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A)","0.76A","3rukB-1nr6A:44.1","3rukA-1nr6A:32.81"],["3RUK_D_AERD601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",7,"ALA A 113;PHE A 114;ASP A 290;GLY A 293;ALA A 294;THR A 298;VAL A 474","DIF A 501 (-3.6A);DIF A 501 (-4.5A);None;DIF A 501 (-3.8A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);None","1.38A","3rukD-1nr6A:43.4","3rukB-1nr6A:32.81"],["3T3S_D_9PLD1_1","CYTOCHROME P450 2A13","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",4,"ALA A 113;PHE A 114;ALA A 294;THR A 298","DIF A 501 (-3.6A);DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A)","0.78A","3t3sD-1nr6A:49.4","3rukD-1nr6A:32.81"],["3T3Z_A_9PLA501_1","CYTOCHROME P450 2E1","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",4,"PHE A 114;ALA A 294;THR A 298;LEU A 363","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);HEM A 500 (-4.0A)","0.70A","3t3zA-1nr6A:50.9","3t3sD-1nr6A:54.62"],["3T3Z_B_9PLB501_1","CYTOCHROME P450 2E1","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",4,"PHE A 114;ALA A 294;THR A 298;LEU A 363","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);HEM A 500 (-4.0A)","0.69A","3t3zB-1nr6A:50.7","3t3zA-1nr6A:57.65"],["3T3Z_C_9PLC501_1","CYTOCHROME P450 2E1","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",4,"PHE A 114;ALA A 294;THR A 298;LEU A 363","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);HEM A 500 (-4.0A)","0.73A","3t3zC-1nr6A:50.7","3t3zB-1nr6A:57.65"],["3T3Z_D_9PLD501_1","CYTOCHROME P450 2E1","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",4,"PHE A 114;ALA A 294;THR A 298;LEU A 363","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);HEM A 500 (-4.0A)","0.70A","3t3zD-1nr6A:50.7","3t3zC-1nr6A:57.65"],["4AC9_C_DXCC1477_0","MJ0495-LIKE PROTEIN","4ubs","PENTALENIC ACID SYNTHASE","Streptomyces avermitilis",4,"GLY A 242;ARG A 175;ILE A 240;LEU A 160","HEM A 501 (-3.6A);PGE A 506 (-4.0A);DIF A 502 (-3.3A);None","1.12A","4ac9C-4ubsA:undetectable","3t3zD-1nr6A:57.65"],["4ACA_C_DXCC1477_0","TRANSLATION ELONGATION FACTOR SELB","4ubs","PENTALENIC ACID SYNTHASE","Streptomyces avermitilis",4,"GLY A 242;ARG A 175;ILE A 240;LEU A 160","HEM A 501 (-3.6A);PGE A 506 (-4.0A);DIF A 502 (-3.3A);None","1.16A","4acaC-4ubsA:undetectable","4ac9C-4ubsA:20.63"],["4EJG_B_NCTB501_1","CYTOCHROME P450 2A13","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",4,"PHE A 114;ALA A 294;THR A 298;LEU A 359","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);DIF A 501 (-4.4A)","0.82A","4ejgB-1nr6A:50.0","4acaC-4ubsA:20.63"],["4EJG_D_NCTD501_1","CYTOCHROME P450 2A13","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",4,"PHE A 114;ALA A 294;THR A 298;LEU A 359","DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);DIF A 501 (-4.4A)","0.81A","4ejgD-1nr6A:50.1","4ejgB-1nr6A:54.62"],["4NKV_A_AERA601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",5,"LEU A 103;ALA A 113;GLY A 293;ALA A 294;THR A 298","DIF A 501 (-3.9A);DIF A 501 (-3.6A);DIF A 501 (-3.8A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A)","1.02A","4nkvA-1nr6A:44.1","4ejgD-1nr6A:54.62"],["4NKV_C_AERC601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",5,"LEU A 103;ALA A 113;PHE A 114;ALA A 294;THR A 298","DIF A 501 (-3.9A);DIF A 501 (-3.6A);DIF A 501 (-4.5A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A)","1.15A","4nkvC-1nr6A:44.0","4nkvA-1nr6A:32.81"],["4NKX_A_STRA601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"LEU A 103;ALA A 113;PHE A 114;GLY A 293;ALA A 294;THR A 298","DIF A 501 (-3.9A);DIF A 501 (-3.6A);DIF A 501 (-4.5A);DIF A 501 (-3.8A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A)","1.13A","4nkxA-1nr6A:44.1","4nkvC-1nr6A:32.81"],["4NKX_B_STRB601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"LEU A 103;ALA A 113;PHE A 114;GLY A 293;ALA A 294;THR A 298","DIF A 501 (-3.9A);DIF A 501 (-3.6A);DIF A 501 (-4.5A);DIF A 501 (-3.8A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A)","1.12A","4nkxB-1nr6A:44.1","4nkxA-1nr6A:32.81"],["4NKX_C_STRC601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"LEU A 103;ALA A 113;PHE A 114;GLY A 293;ALA A 294;THR A 298","DIF A 501 (-3.9A);DIF A 501 (-3.6A);DIF A 501 (-4.5A);DIF A 501 (-3.8A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A)","1.07A","4nkxC-1nr6A:44.0","4nkxB-1nr6A:32.81"],["4NKX_D_STRD601_1","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"LEU A 103;ALA A 113;PHE A 114;GLY A 293;ALA A 294;THR A 298","DIF A 501 (-3.9A);DIF A 501 (-3.6A);DIF A 501 (-4.5A);DIF A 501 (-3.8A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A)","1.11A","4nkxD-1nr6A:44.1","4nkxC-1nr6A:32.81"],["4R1Z_A_AERA601_1","CYP17A1 PROTEIN","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",5,"ALA A 113;ASP A 290;GLY A 293;ALA A 294;THR A 298","DIF A 501 (-3.6A);None;DIF A 501 (-3.8A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A)","0.95A","4r1zA-1nr6A:44.1","4nkxD-1nr6A:32.81"],["4R20_B_AERB602_1","CYTOCHROME P450 FAMILY 17 POLYPEPTIDE 2","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",5,"ALA A 113;PHE A 114;ILE A 240;THR A 298;VAL A 205","DIF A 501 (-3.6A);DIF A 501 (-4.5A);None;HEM A 500 ( 3.6A);None","1.23A","4r20B-1nr6A:43.5","4r1zA-1nr6A:32.39"],["4ZF8_A_MYTA502_1","BIFUNCTIONAL P-450\/NADPH-P450 REDUCTASE","4ubs","PENTALENIC ACID SYNTHASE","Streptomyces avermitilis",4,"LEU A 178;ILE A 240;ALA A 241;ALA A 288","None;DIF A 502 (-3.3A);HEM A 501 ( 3.8A);HEM A 501 ( 3.7A)","0.63A","4zf8A-4ubsA:31.8","4r20B-1nr6A:35.58"],["5GWX_A_SAMA301_0","GLYCINE SARCOSINE N-METHYLTRANSFERASE","2wek","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","Homo sapiens",5,"GLY A 270;PHE A 303;GLY A 274;SER A 273;SER A  77","NAP A1372 (-3.3A);NAP A1372 (-4.9A);None;NAP A1372 (-4.8A);DIF A1373 (-3.0A)","1.05A","5gwxA-2wekA:7.6","4zf8A-4ubsA:24.45"],["5TL8_A_X2NA502_1","PROTEIN CYP51","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"ALA A  47;PHE A 114;ALA A 113;ALA A 294;THR A 298;LEU A 359","None;DIF A 501 (-4.5A);DIF A 501 (-3.6A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);DIF A 501 (-4.4A)","1.38A","5tl8A-1nr6A:34.9","5gwxA-2wekA:20.27"],["5X23_A_LSNA502_1","CYTOCHROME P450 2C9","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",5,"PHE A 114;GLY A 293;ALA A 294;LEU A 359;LEU A 363","DIF A 501 (-4.5A);DIF A 501 (-3.8A);DIF A 501 ( 3.3A);DIF A 501 (-4.4A);HEM A 500 (-4.0A)","0.58A","5x23A-1nr6A:55.6","5tl8A-1nr6A:28.71"],["5X24_A_LSNA502_1","CYTOCHROME P450 2C9","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"ASN A 204;LEU A 233;ASP A 290;GLY A 293;THR A 298;LEU A 363","None;None;None;DIF A 501 (-3.8A);HEM A 500 ( 3.6A);HEM A 500 (-4.0A)","0.86A","5x24A-1nr6A:55.2","5x23A-1nr6A:76.47"],["5X24_A_LSNA502_1","CYTOCHROME P450 2C9","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",5,"PHE A 114;LEU A 233;ASP A 290;THR A 298;LEU A 363","DIF A 501 (-4.5A);None;None;HEM A 500 ( 3.6A);HEM A 500 (-4.0A)","0.84A","5x24A-1nr6A:55.2","5x24A-1nr6A:76.26"],["5XXI_A_LSNA501_1","CYTOCHROME P450 2C9","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"ASN A 204;ASP A 290;GLY A 293;ALA A 294;LEU A 359;LEU A 363","None;None;DIF A 501 (-3.8A);DIF A 501 ( 3.3A);DIF A 501 (-4.4A);HEM A 500 (-4.0A)","0.61A","5xxiA-1nr6A:55.4","5x24A-1nr6A:76.26"],["5XXI_A_LSNA503_1","CYTOCHROME P450 2C9","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",5,"PHE A 114;LEU A 359;PRO A 360;THR A 361;PRO A 364","DIF A 501 (-4.5A);DIF A 501 (-4.4A);None;None;None","0.67A","5xxiA-1nr6A:55.4","5xxiA-1nr6A:76.24"],["6A7J_A_TESA502_0","CYTOCHROME P450","4ubs","PENTALENIC ACID SYNTHASE","Streptomyces avermitilis",4,"LEU A  93;LEU A 237;ALA A 241;THR A 245","HEM A 501 ( 4.1A);DIF A 502 (-4.4A);HEM A 501 ( 3.8A);HEM A 501 ( 3.3A)","0.68A","6a7jA-4ubsA:29.8","5xxiA-1nr6A:76.24"],["6AYC_A_1YNA502_1","PROTEIN CYP51","1nr6","CYTOCHROME P450 2C5","Oryctolagus cuniculus",6,"ALA A  47;PHE A 114;ALA A 113;ALA A 294;THR A 298;LEU A 359","None;DIF A 501 (-4.5A);DIF A 501 (-3.6A);DIF A 501 ( 3.3A);HEM A 500 ( 3.6A);DIF A 501 (-4.4A)","1.45A","6aycA-1nr6A:35.2","6a7jA-4ubsA:14.79"]]